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UniProtKB/Swiss-Prot entry P22443

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CP19A_RAT
Primary accession number P22443
Secondary accession numbers None
Integrated into Swiss-Prot on August 1, 1991
Sequence was last modified on August 1, 1991 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 66)
Name and origin of the protein
Protein name Cytochrome P450 19A1
Synonyms EC 1.14.14.1
CYPXIX
Aromatase
Estrogen synthetase
P-450AROM
Gene name
Name: Cyp19a1
Synonyms: Arom, Cyp19
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Ovary;
PubMed=2157976 [NCBI, ExPASy, EBI, Israel, Japan]
Hickey G.J., Krasnow J.S., Beattie W.G., Richards J.S.;
"Aromatase cytochrome P450 in rat ovarian granulosa cells before and after luteinization: adenosine 3',5'-monophosphate-dependent and independent regulation. Cloning and sequencing of rat aromatase cDNA and 5' genomic DNA.";
Mol. Endocrinol. 4:3-12(1990).
[2]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/0303-7207(90)90056-E; PubMed=2340950 [NCBI, ExPASy, EBI, Israel, Japan]
Lephart E.D., Peterson K.G., Noble J.F., George F.W., McPhaul M.J.;
"The structure of cDNA clones encoding the aromatase P-450 isolated from a rat Leydig cell tumor line demonstrates differential processing of aromatase mRNA in rat ovary and a neoplastic cell line.";
Mol. Cell. Endocrinol. 70:31-40(1990).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M33986; AAA41044.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A36121; A36121.
UniGene Rn.21402
3D structure databases
ModBase P22443.
Organism-specific databases
RGD 2457; Cyp19a1.
Gene expression databases
ArrayExpress P22443; -.
Ontologies
GO
GO:0016020; Cellular component: membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0020037; Molecular function: heme binding (inferred from electronic annotation from InterPro).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from InterPro).
GO:0050381; Molecular function: unspecific monooxygenase activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001128; Cyt_P450.
IPR002401; Cyt_P450_E_grp-I.
Graphical view of domain structure.
Gene3D G3DSA:1.10.630.10; Cyt_P450; 1.
PANTHER PTHR19383; Cyt_P450; 1.
Pfam PF00067; p450; 1.
Pfam graphical view of domain structure.
PRINTS PR00463; EP450I.
PR00385; P450.
PROSITE PS00086; CYTOCHROME_P450; 1.
ProtoNet P22443.
Genome annotation databases
Ensembl ENSRNOG00000000196; Rattus norvegicus. [Contig view]
Phylogenomic databases
HOVERGEN P22443; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   508  508     Cytochrome P450 19A1. PRO_0000051962
METAL   437   437        Iron (heme axial ligand). 
CONFLICT   3     4        LE -> FQ (in Ref. 2). 
CONFLICT   10    10        H -> Q (in Ref. 2). 
CONFLICT   88    88        W -> C (in Ref. 2). 
CONFLICT   101   101        S -> L (in Ref. 2). 
CONFLICT   123   129        QCIGMHE -> VVHGHAR (in Ref. 2). 
CONFLICT   188   188        V -> L (in Ref. 2). 
CONFLICT   210   210        E -> G (in Ref. 2). 
CONFLICT   328   331        VETA -> WKQ (in Ref. 2). 
CONFLICT   342   342        D -> A (in Ref. 2). 
CONFLICT   364   369        LRYQPV -> CGISPF (in Ref. 2). 
CONFLICT   422   422        V -> L (in Ref. 2). 
CONFLICT   425   425        R -> T (in Ref. 2). 
CONFLICT   449   449        V -> I (in Ref. 2). 
CONFLICT   466   466        R -> K (in Ref. 2). 
CONFLICT   493   497        RHIFN -> SPRNS (in Ref. 2). 
Sequence information
Length: 508 AA [This is the length of the unprocessed precursor] Molecular weight: 58412 Da [This is the MW of the unprocessed precursor] CRC64: C0ADFB0FD80AB352 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MFLEMLNPMH YNVTIMVPET VPVSAMPLLL IMGLLLLIRN CESSSSIPGP GYCLGIGPLI 

        70         80         90        100        110        120 
SHGRFLWMGI GSACNYYNKM YGEFMRVWIS GEETLIISKS SSMVHVMKHS NYISRFGSKR 

       130        140        150        160        170        180 
GLQCIGMHEN GIIFNNNPSL WRTVRPFFMK ALTGPGLIRM VEVCVESIKQ HLDRLGDVTD 

       190        200        210        220        230        240 
NSGYVDVVTL MRHIMLDTSN TLFLGIPLDE SSIVKKIQGY FNAWQALLIK PNIFFKISWL 

       250        260        270        280        290        300 
YRKYERSVKD LKDEIEILVE KKRQKVSSAE KLEDCMDFAT DLIFAERRGD LTKENVNQCI 

       310        320        330        340        350        360 
LEMLIAAPDT MSVTLYVMLL LIAEYPEVET AILKEIHTVV GDRDIRIGDV QNLKVVENFI 

       370        380        390        400        410        420 
NESLRYQPVV DLVMRRALED DVIDGYPVKK GTNIILNIGR MHRLEYFPKP NEFTLENFEK 

       430        440        450        460        470        480 
NVPYRYFQPF GFGPRSCAGK YIAMVMMKVV LVTLLKRFHV KTLQKRCIEN MPKNNDLSLH 

       490        500 
LDEDSPIVEI IFRHIFNTPF LQCLYISL
P22443 in FASTA format

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