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UniProtKB/Swiss-Prot entry P18943

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name COX1_CHICK
Primary accession number P18943
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1990
Sequence was last modified on November 1, 1990 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 61)
Name and origin of the protein
Protein name Cytochrome c oxidase subunit 1
Synonyms EC 1.9.3.1
Cytochrome c oxidase polypeptide I
Gene name
Name: MT-CO1
Synonyms: COI, COXI, MTCO1
From
Gallus gallus (Chicken) [TaxID: 9031] 
Encoded on Mitochondrion.
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=White leghorn;
TISSUE=Liver;
DOI=10.1016/0022-2836(90)90225-B; PubMed=2329578 [NCBI, ExPASy, EBI, Israel, Japan]
Desjardins P., Morais R.;
"Sequence and gene organization of the chicken mitochondrial genome. A novel gene order in higher vertebrates.";
J. Mol. Biol. 212:599-634(1990).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X52392; CAA36627.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S10189; S10189.
RefSeq NP_006917.1; -.
3D structure databases
HSSP P00396; 2OCC. [HSSP ENTRY / PDB]
SMR P18943; 3-514.
ModBase P18943.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0005746; Cellular component: mitochondrial respiratory chain (inferred from electronic annotation from UniProtKB-KW).
GO:0005507; Molecular function: copper ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004129; Molecular function: cytochrome-c oxidase activity (inferred from electronic annotation from EC).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0020037; Molecular function: heme binding (inferred from electronic annotation from InterPro).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from InterPro).
GO:0009060; Biological process: aerobic respiration (inferred from electronic annotation from InterPro).
GO:0022900; Biological process: electron transport chain (inferred from electronic annotation from UniProtKB-KW).
GO:0006810; Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000883; COX1.
Graphical view of domain structure.
Gene3D G3DSA:1.20.210.10; COX1; 1.
PANTHER PTHR10422; COX1; 1.
Pfam PF00115; COX1; 1.
Pfam graphical view of domain structure.
PRINTS PR01165; CYCOXIDASEI.
PROSITE PS50855; COX1; 1.
PS00077; COX1_CUB; 1.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
Ensembl ENSGALG00000018373; Gallus gallus. [Contig view]
GeneID 807639; -.
KEGG gga:807639; -.
Phylogenomic databases
HOVERGEN P18943; -.
Other
ProtoNet P18943.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Copper; Electron transport; Heme; Iron; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Respiratory chain; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   515  515     Cytochrome c oxidase subunit 1. PRO_0000183306
TRANSMEM   18    38  21     Potential. 
TRANSMEM   57    77  21     Potential. 
TRANSMEM   103   123  21     Potential. 
TRANSMEM   146   166  21     Potential. 
TRANSMEM   183   203  21     Potential. 
TRANSMEM   234   254  21     Potential. 
TRANSMEM   268   288  21     Potential. 
TRANSMEM   310   330  21     Potential. 
TRANSMEM   338   358  21     Potential. 
TRANSMEM   380   400  21     Potential. 
TRANSMEM   414   434  21     Potential. 
TRANSMEM   456   476  21     Potential. 
METAL   62    62        Iron (heme A axial ligand) (Probable). 
METAL   240   240        Copper B (Probable). 
METAL   244   244        Copper B (Probable). 
METAL   290   290        Copper B (Probable). 
METAL   291   291        Copper B (Probable). 
METAL   376   376        Iron (heme A3 axial ligand) (Probable). 
METAL   378   378        Iron (heme A axial ligand) (Probable). 
CROSSLNK   240   244        1'-histidyl-3'-tyrosine (His-Tyr) (By similarity). 
Sequence information
Length: 515 AA [This is the length of the unprocessed precursor] Molecular weight: 57051 Da [This is the MW of the unprocessed precursor] CRC64: 29EF4E3DB9B9CDA9 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTFINRWLFS TNHKDIGTLY LIFGTWAGMA GTALSLLIRA ELGQPGTLLG DDQIYNVIVT 

        70         80         90        100        110        120 
AHAFVMIFFM VMPIMIGGFG NWLVPLMIGA PDMAFPRMNN MSFWLLPPSF LLLLASSTVE 

       130        140        150        160        170        180 
AGAGTGWTVY PPLAGNLAHA GASVDLAIFH YLAGVSSILG AINFITTIIN MKPPALSQYQ 

       190        200        210        220        230        240 
TPLFVWSVLI TAILLLLSLP VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH 

       250        260        270        280        290        300 
PEVYILILPG FGMISHVVAY YAGKKEPFGY MGMVWAMLSI GFLGFIVWAH HMFTVRMDVD 

       310        320        330        340        350        360 
TRAYFTSATM IIAIPTGIKV FSWLATLHGG TIKWDPPMLW ALGFIFLFTI GGLTGIVLAN 

       370        380        390        400        410        420 
SSLDIALHDT YYVVAHFHYV LSMGAVFAIL AGFTHWFPLF TGFTLHPSWT KAHFGVMFTG 

       430        440        450        460        470        480 
VNLTFFPQHF LGLAGMPRRY SDYPDAYTLW NTLSSIGSLI SMTAVIMLMF IVWEAFSAKR 

       490        500        510 
KVLQPELTAT NIEWIHGCPP PYHTFEEPAF VQVQE
P18943 in FASTA format

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