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UniProtKB/Swiss-Prot entry P16490

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ORF2A_CMVFN
Primary accession number P16490
Secondary accession numbers None
Integrated into Swiss-Prot on August 1, 1990
Sequence was last modified on August 1, 1990 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 43)
Name and origin of the protein
Protein name RNA-directed RNA polymerase 2A
Synonyms protein 2A
EC 2.7.7.48
Gene name
Name: RNA2
ORFNames: ORF2a
From
Cucumber mosaic virus (strain FNY) (CMV) [TaxID: 12307] 
Taxonomy Viruses; ssRNA positive-strand viruses, no DNA stage; Bromoviridae; Cucumovirus.
Virus hosts Cucurbita pepo (Vegetable marrow) (Summer squash) [TaxID: 3663]
Nicotiana tabacum (Common tobacco) [TaxID: 4097]
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC RNA].
PubMed=3404113 [NCBI, ExPASy, EBI, Israel, Japan]
Rizzo T.M., Palukaitis P.;
"Nucleotide sequence and evolutionary relationships of cucumber mosaic virus (CMV) strains: CMV RNA 2.";
J. Gen. Virol. 69:1777-1787(1988).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
D00355; BAA00263.1; -; Genomic_RNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR JQ0015; WMVXCU.
RefSeq NP_049324.1; -.
3D structure databases
ModBase P16490.
Ontologies
GO
GO:0000166; Molecular function: nucleotide binding (inferred from electronic annotation from UniProtKB-KW).
GO:0003723; Molecular function: RNA binding (inferred from electronic annotation from InterPro).
GO:0003968; Molecular function: RNA-directed RNA polymerase activity (inferred from electronic annotation from InterPro).
GO:0006410; Biological process: transcription, RNA-dependent (inferred from electronic annotation from UniProtKB-KW).
GO:0019079; Biological process: viral genome replication (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001788; RNA-dep_RNA_pol_vir-typ.
IPR007094; RNA_pol_PSvir.
Graphical view of domain structure.
Pfam PF00978; RdRP_2; 1.
Pfam graphical view of domain structure.
PROSITE PS50507; RDRP_SSRNA_POS; 1.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
GeneID 962642; -.
Other
ProtoNet P16490.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Nucleotide-binding; Nucleotidyltransferase; RNA replication; RNA-directed RNA polymerase; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   857  857     RNA-directed RNA polymerase 2A. PRO_0000083273
DOMAIN   511   624  114     RdRp catalytic. 
Sequence information
Length: 857 AA [This is the length of the unprocessed precursor] Molecular weight: 96710 Da [This is the MW of the unprocessed precursor] CRC64: 5BBA030FE68D7B2B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAFPAPAFSL ANLLNGSYGV DTPEDVERLR SEQREEAAAA CRNYRPLPAV DVSESVTEDA 

        70         80         90        100        110        120 
HSLRTPDGAP AEAVSDEFVT YGAEDYLEKS DDELLVAFET MVKPMRIGQL WCPAFNKCSF 

       130        140        150        160        170        180 
ISSIAMARAL LLAPRTSHRT MKCFEDLVAA IYTKSDFYYS EECEADDAQI DISSRDVPGY 

       190        200        210        220        230        240 
SFEPWSRTSG FEPPPICEAC DMIMYQCPCF DFNALKKSCA ERTFADDYVI EGLDGVVDNA 

       250        260        270        280        290        300 
TLLSNLGPFL VPVKCQYEKC PTPTIAIPPD LNRATDRVDI NLVQSICDST LPTHSNYDDS 

       310        320        330        340        350        360 
FHQVFVESAD YSIDLDHVRL RQSDLIAKIP DSGHMIPVLN TGSGHKRVGT TKEVLTAIKK 

       370        380        390        400        410        420 
RNADVPELGD SVNLSRLSKA VAERFFISYI NGNSLASSNF VNVVSNFHDY MEKWKSSGLS 

       430        440        450        460        470        480 
YDDLPDLHAE NLQFYDHMIK SDVKPVVSDT LNIDRPVPAT ITYHKKSITS QFSPLFTALF 

       490        500        510        520        530        540 
ERFQRCLRER IILPVGKISS LEMAGFDVKN KHCLEIDLSK FDKSQGEFHL LIQEHILNGL 

       550        560        570        580        590        600 
GCPAPITKWW CDFHRFSYIR DRRAGVGMPI SFQRRTGDAL TYFGNTIVTM AEFAWCYDTD 

       610        620        630        640        650        660 
QFEKLLFSGD DSLGFSLLPP VGDPSKFTTL FNMEAKVMEP AVPYICSKFL LSDEFGNTFS 

       670        680        690        700        710        720 
VPDPLREVQR LGTKKIPYSD NDEFLFAHFM SFVDRLKFLD RMSQSCIDQL SIFFELKYKK 

       730        740        750        760        770        780 
SGEEAALMLG AFKKYTANFQ SYKELYYSDR RQCELINSFC STEFRVERVN SNKQRKNYGI 

       790        800        810        820        830        840 
ERRCNDKRRT PTGSYGGGEE AETKVSQTES TGTRSQKSQR ESAFKSQTIP LPTVLSSGWF 

       850 
GTDRVMPPCE RGGVTRV
P16490 in FASTA format

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