[1]	PROTEIN SEQUENCE. TISSUE=Pancreas; DOI=10.1016/0300-9084(84)90025-7; PubMed=6547861 [NCBI, ExPASy, EBI, Israel, Japan] Bosc-Bierne I., Rathelot J., Bechis G., Delori P., Sarda L.; "Evidence for the existence of procolipase in chicken pancreas and pancreatic juice."; Biochimie 66:413-416(1984).
[2]	PROTEIN SEQUENCE. TISSUE=Pancreas; DOI=10.1016/0005-2795(81)90187-2; PubMed=7213802 [NCBI, ExPASy, EBI, Israel, Japan] Bosc-Bierne I., Rathelot J., Canioni P., Julien R., Bechis G., Gregorie J., Rochat H., Sarda L.; "Isolation and partial structural characterization of chicken pancreatic colipase."; Biochim. Biophys. Acta 667:225-232(1981).

Comments

FUNCTION: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
SUBUNIT: Forms a 1:1 stoichiometric complex with pancreatic lipase.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed by the pancreas.
SIMILARITY: Belongs to the colipase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases
PIR	A05330; A05330.
UniGene	Gga.6607
3D structure databases
HSSP	P02703; 1LPB. [HSSP ENTRY / PDB]
ModBase	P11148.
Family and domain databases
InterPro	IPR001981; Colipase. Graphical view of domain structure.
Pfam	PF01114; Colipase; 1. Pfam graphical view of domain structure.
PROSITE	PS00121; COLIPASE_1; PARTIAL. PS51342; COLIPASE_2; 1. PROSITE graphical view of domain structure (profiles).
BLOCKS	P11148.
Genome annotation databases
Ensembl	ENSGALG00000000900; Gallus gallus. [Contig view]
Phylogenomic databases
HOGENOM	P11148; -.
HOVERGEN	P11148; -.
Other
ProtoNet	P11148.
UniRef	View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Digestion; Direct protein sequencing; Lipid degradation; Secreted.

Features

Feature table viewer

Sequence information

Length: 34 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 3591 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: 4A646B55FCB83BEB [This is a checksum on the sequence]

        10         20         30 
GLIFNLDTGE LCLQSAQCKS ECCQEDSGLS LAXC

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools