[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. PubMed=1886714 [NCBI, ExPASy, EBI, Israel, Japan] Coulier F., Batoz M., Marics I., de Lapeyriere O., Birnbaum D.; "Putative structure of the FGF6 gene product and role of the signal peptide."; Oncogene 6:1437-1444(1991).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ALA-36; VAL-63; VAL-174 AND TRP-191. NIEHS SNPs program; Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[4]	NUCLEOTIDE SEQUENCE [MRNA] OF 11-208. PubMed=1549352 [NCBI, ExPASy, EBI, Israel, Japan] Iida S., Yoshida T., Naito K., Sakamoto H., Katoh O., Hirohashi S., Sato T., Onda M., Sugimura T., Terada M.; "Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization."; Oncogene 7:303-309(1992).
[5]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-208. PubMed=2649847 [NCBI, ExPASy, EBI, Israel, Japan] Marics I., Adelaide J., Raybaud F., Mattei M.-G., Coulier F., Planche J., de Lapeyriere O., Birnbaum D.; "Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family."; Oncogene 4:335-340(1989).

Comments

FUNCTION: Can transform NIH 3T3 cells. Exhibits strong mitogenic and angiogenic properties.
SUBCELLULAR LOCATION: Secreted, extracellular space.
TISSUE SPECIFICITY: Leukemia cell lines with platelet/ megakaryocytic differentiation potential.
SIMILARITY: Belongs to the heparin-binding growth factors family.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/fgf6/";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X57075; CAA40358.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X57075; CAA40359.1; ALT_INIT; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X57075; CAA40360.1; ALT_INIT; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY581424; AAS79318.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC121097; AAI21098.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC121098; AAI21099.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X63454; CAA45054.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X14071; CAB37648.2; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X14072; CAB37648.2; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X14073; CAB37648.2; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

S20102; S20102.

NP_066276.2; -.

3D structure databases

HSSP

P08620; 1IJT. [HSSP ENTRY / PDB]

ModBase

P10767.

Protein-protein interaction databases

DIP

DIP:6035N; -.

PTM databases

PhosphoSite

P10767; -.

Enzyme and pathway databases

Reactome

REACT_9470; Signaling by FGFR.

Organism-specific databases

GC12M004413; -.

HIX0036856; -.

HGNC:3684; FGF6.

134921; gene. [NCBI / EBI]

PharmGKB

PA28123; -.

GeneCards

P10767.

Gene expression databases

ArrayExpress

P10767; -.

CleanEx

HS_FGF6; -.

GermOnline

ENSG00000111241; Homo sapiens.

Ontologies

GO:0005576;	Cellular component: extracellular region (traceable author statement from ProtInc).
GO:0008083;	Molecular function: growth factor activity (traceable author statement from ProtInc).
GO:0001525;	Biological process: angiogenesis (inferred from electronic annotation from UniProtKB-KW).
GO:0008283;	Biological process: cell proliferation (traceable author statement from ProtInc).
GO:0007267;	Biological process: cell-cell signaling (traceable author statement from ProtInc).
GO:0008543;	Biological process: fibroblast growth factor receptor signaling pathway (inferred from experiment from Reactome).
QuickGo view.

Family and domain databases

InterPro

IPR002209; GF_heparin_bd.
IPR002348; IL1_HBGF.
Graphical view of domain structure.

PANTHER

PTHR11486; IL1_HBGF; 1.

Pfam

PF00167; FGF; 1.
Pfam graphical view of domain structure.

PRINTS

PR00263; HBGFFGF.
PR00262; IL1HBGF.

ProDom

PD000831; IL1_HBGF; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00442; FGF; 1.
SMART graphical view of domain structure.

PROSITE

PS00247; HBGF_FGF; 1.

Proteomics databases

PRIDE

P10767; -.

Genome annotation databases

Ensembl

ENSG00000111241; Homo sapiens. [Contig view]

GeneID

2251; -.

KEGG

hsa:2251; -.

NMPDR

fig|9606.3.peg.6985; -.

Phylogenomic databases

HOGENOM

P10767; -.

HOVERGEN

P10767; -.

Other

9113; -.

FGF6; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Angiogenesis; Developmental protein; Differentiation; Glycoprotein; Growth factor; Mitogen; Polymorphism; Proto-oncogene; Secreted; Signal.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 37`	`37`	`Potential.`
`CHAIN`	`38 208`	`171`	`Fibroblast growth factor 6.`	`PRO_0000008961`
`CARBOHYD`	`45 45`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`90 157`		`Potential.`
`VARIANT`	`36 36`	`1`	`V -> A (in dbSNP:rs11613495 [NCBI]).`	`VAR_018882`
`VARIANT`	`63 63`	`1`	`A -> V (in dbSNP:rs17183529 [NCBI]).`	`VAR_018883`
`VARIANT`	`174 174`	`1`	`D -> V (in dbSNP:rs7961645 [NCBI]).`	`VAR_018884`
`VARIANT`	`191 191`	`1`	`R -> W (in dbSNP:rs17183778 [NCBI]).`	`VAR_018885`
`CONFLICT`	`100 100`		`V -> G (in Ref. 5; CAB37648).`

Sequence information

Length: 208 AA [This is the length of the unprocessed precursor]

Molecular weight: 22905 Da [This is the MW of the unprocessed precursor]

CRC64: 79EF44685B324322 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MALGQKLFIT MSRGAGRLQG TLWALVFLGI LVGMVVPSPA GTRANNTLLD SRGWGTLLSR 

        70         80         90        100        110        120 
SRAGLAGEIA GVNWESGYLV GIKRQRRLYC NVGIGFHLQV LPDGRISGTH EENPYSLLEI 

       130        140        150        160        170        180 
STVERGVVSL FGVRSALFVA MNSKGRLYAT PSFQEECKFR ETLLPNNYNA YESDLYQGTY 

       190        200 
IALSKYGRVK RGSKVSPIMT VTHFLPRI

P10767 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools