FUNCTION: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. May play a role in the intracellular survival of mycobacteria (By similarity).
CATALYTIC ACTIVITY: 2 H₂O₂ = O₂ + 2 H₂O.
CATALYTIC ACTIVITY: Donor + H₂O₂ = oxidized donor + 2 H₂O.
COFACTOR: Binds 1 heme B (iron-protoporphyrin IX) group per dimer (By similarity).
SUBUNIT: Homodimer or homotetramer (By similarity).
PTM: The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme (By similarity).
SIMILARITY: Belongs to the peroxidase family. Peroxidase/catalase subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U46844; AAC45275.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

Q939D2; 1MWV. [HSSP ENTRY / PDB]

ModBase

P0C580.

Ontologies

GO:0004096;	Molecular function: catalase activity (inferred from electronic annotation from InterPro).
GO:0020037;	Molecular function: heme binding (inferred from electronic annotation from InterPro).
GO:0005506;	Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0042744;	Biological process: hydrogen peroxide catabolic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

HAMAP

MF_01961; -; 1.
PBIL [Tree]

InterPro

IPR000763; Catalase_proxase.
IPR002016; Haem_peroxidase_pln/fun/bac.
Graphical view of domain structure.

Pfam

PF00141; peroxidase; 2.
Pfam graphical view of domain structure.

PRINTS

PR00460; BPEROXIDASE.
PR00458; PEROXIDASE.

TIGRFAMs

TIGR00198; cat_per_HPI; 1.

PROSITE

PS00435; PEROXIDASE_1; 1.
PS00436; PEROXIDASE_2; 1.
PS50873; PEROXIDASE_4; 1.
PROSITE graphical view of domain structure (profiles).

Other

ProtoNet

P0C580.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Heme; Hydrogen peroxide; Iron; Metal-binding; Oxidoreductase; Peroxidase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 740`	`740`	`Catalase-peroxidase.`	`PRO_0000055573`
`ACT_SITE`	`114 114`		`Proton acceptor (By similarity).`
`METAL`	`278 278`		`Iron (heme axial ligand) (By similarity).`
`SITE`	`110 110`	`1`	`Transition state stabilizer (By similarity).`
`CROSSLNK`	`113 237`		`Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-263) (By similarity).`
`CROSSLNK`	`237 263`		`Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-113) (By similarity).`

Sequence information

Length: 740 AA [This is the length of the unprocessed precursor]

Molecular weight: 81230 Da [This is the MW of the unprocessed precursor]

CRC64: 397CF9B5AA7E1AE7 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MPEDRPIEDS PPIGEAQTDA PAGGCPAGFG RIKPPVAGGS NXDWWPNQLN MKILQKNPDV 

        70         80         90        100        110        120 
INPLDEDFDY RSAVQNLDVD ALRADIVEVM HTSQDWWPAD FGHYGPLFIR MAWHAAGTYR 

       130        140        150        160        170        180 
VSDGRGGAGA GMQRFAPLNS WPDNASLDKA RRLLWPVKKK YGKNLSWADL IVYAGNVALE 

       190        200        210        220        230        240 
DMGFRTAGFA FGREDRWEPE EDVYWGPEQE WLDRTKRYTG ERDLENPLAA VQMGLIYVNP 

       250        260        270        280        290        300 
EGPNGNPDPQ ASAIDIRETF GRMAMNDVET AALIVGGHTF GKTHGNGDAS LVGPEPEAAP 

       310        320        330        340        350        360 
LEEVGLGWRN PQGTGVGKDA ITSGLEVTWT HTPTKWDNSF LEILYGNEWE LTKSPAGANQ 

       370        380        390        400        410        420 
WKPKDNGWAN SVPLAHEDGK THPSMLTSDL ALRVDPIYEQ ITRRWLDHPE ELAEEFAKAW 

       430        440        450        460        470        480 
FKLLHRDMGP VTRYLGPEVP KDTWLWQDNI PAGNDLSDDE VAKLKELIAD SGLTVSQLVS 

       490        500        510        520        530        540 
TAWKAASTFR SSDLRGGANG GRIRLQPQLG WEANEPDELA QVVRKYEEIQ KASGINVSFA 

       550        560        570        580        590        600 
DLVVLGGNVG VEKAAKAAGF DVTVPFTPGR GDATQEETDV DSFAYLEPKA DGFRNYLGKG 

       610        620        630        640        650        660 
SDLPAEFKLI DRANLLGLSA PEMTTLVGGL RVLDVNHGGT KHGVLTDKPG ALTTDFFVNL 

       670        680        690        700        710        720 
LDMSTAWKPS PADDGTYIGT DRATGSPKWT GTRVDLVFAS NSQLRALAEV YAEDDSKEKF 

       730        740 
VKDFVAAWTK VMDADRFDVA

P0C580 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools