[1]	PROTEIN SEQUENCE, MASS SPECTROMETRY, AND HYDROXYLATION. TISSUE=Bone; DOI=10.1126/science.1137614; PubMed=17431180 [NCBI, ExPASy, EBI, Israel, Japan] Asara J.M., Schweitzer M.H., Freimark L.M., Phillips M., Cantley L.C.; "Protein sequences from Mastodon and Tyrannosaurus rex revealed by mass spectrometry."; Science 316:280-285(2007).
[2]	SEQUENCE REVISION TO 27 AND 470. TISSUE=Bone; Asara J.M.; Submitted (SEP-2007) to UniProtKB.
[3]	COMMENTS ON INTERPRETATION OF POTENTIAL HYDROXYLATION SITES. DOI=10.1126/science.317.5843.1324; PubMed=17823333 [NCBI, ExPASy, EBI, Israel, Japan] Asara J.M., Garavelli J.S., Slatter D.A., Schweitzer M.H., Freimark L.M., Phillips M., Cantley L.C.; "Interpreting sequences from mastodon and T. rex."; Science 317:1324-1325(2007).

Comments

FUNCTION: Type I collagen is a member of group I collagen (fibrillar forming collagen).
SUBUNIT: Trimers of one alpha 2(I) and two alpha 1(I) chains (By similarity).
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).
PTM: Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains (By similarity).
MISCELLANEOUS: These protein fragments where extracted from a 68 millions years old fossil. The tryptic peptides required multiple purification steps in order to eliminate contaminants and to increase the concentration of peptidic material.
SIMILARITY: Belongs to the fibrillar collagen family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

3D structure databases

ModBase

P0C2W2.

Ontologies

GO:0005578;	Cellular component: proteinaceous extracellular matrix (inferred from electronic annotation from UniProtKB-KW).
GO:0005198;	Molecular function: structural molecule activity (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR008160; Collagen.
Graphical view of domain structure.

Pfam

PF01391; Collagen; 1.
Pfam graphical view of domain structure.

Other

ProtoNet

P0C2W2.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Collagen; Direct protein sequencing; Extinct organism protein; Extracellular matrix; Hydroxylation; Repeat; Secreted.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`<1 >570`	`>570`	`Collagen alpha-1(I) chain.`	`PRO_0000286177`
`MOD_RES`	`6 6`		`4-hydroxyproline.`
`MOD_RES`	`15 15`		`4-hydroxyproline.`
`MOD_RES`	`30 30`		`4-hydroxyproline.`
`MOD_RES`	`294 294`		`4-hydroxyproline.`
`MOD_RES`	`474 474`		`4-hydroxyproline.`
`MOD_RES`	`480 480`		`4-hydroxyproline.`
`MOD_RES`	`567 567`		`4-hydroxyproline.`
`NON_TER`	`1 1`
`NON_TER`	`570 570`

Sequence information

Length: 570 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 61737 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: FE4DE139C463BEBF [This is a checksum on the sequence]

        10         20         30         40         50         60 
GATGAPGIAG APGFPGARGA PGPQGPSGAP GPKXXXXXXX XXXXXXXXXX XXXXXXXXXX 

        70         80         90        100        110        120 
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX 

       130        140        150        160        170        180 
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX 

       190        200        210        220        230        240 
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX 

       250        260        270        280        290        300 
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXGV QGPPGPQGPR 

       310        320        330        340        350        360 
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX 

       370        380        390        400        410        420 
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX 

       430        440        450        460        470        480 
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXGS AGPPGATGFP 

       490        500        510        520        530        540 
GAAGRXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX 

       550        560        570 
XXXXXXXXXX XXXXXXXXXX XGVVGLPGQR

P0C2W2 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools