PROTEIN SEQUENCE, FUNCTION, AND SUBUNIT.
TISSUE=Venom;
PubMed=9781840 [NCBI, ExPASy, EBI, Israel, Japan]
Abe Y., Shimoyama Y., Munakata H., Ito J., Nagata N., Ohtsuki K.;
"Characterization of an apoptosis-inducing factor in Habu snake venom as a glycyrrhizin (GL)-binding protein potently inhibited by GL in vitro.";
Biol. Pharm. Bull. 21:924-927(1998).

Comments

FUNCTION: Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids. Inhibits platelet aggregation. Has an ability to induce hemorrhage. Has an antibacterial activity (By similarity). Has an ability to induce hemolysis and apoptosis.
CATALYTIC ACTIVITY: An L-amino acid + H₂O + O₂ = a 2-oxo acid + NH₃ + H₂O₂.
COFACTOR: FAD (By similarity).
SUBUNIT: Monomer.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed by the venom gland.
PTM: Glycosylated (By similarity).
SIMILARITY: Belongs to the flavin monoamine oxidase family. FIG1 subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

3D structure databases

ModBase

P0C2D5.

Ontologies

GO:0005576;	Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-KW).
GO:0001716;	Molecular function: L-amino-acid oxidase activity (inferred from electronic annotation from EC).
GO:0006915;	Biological process: apoptosis (inferred from electronic annotation from UniProtKB-KW).
GO:0007596;	Biological process: blood coagulation (inferred from electronic annotation from UniProtKB-KW).
GO:0019835;	Biological process: cytolysis (inferred from electronic annotation from UniProtKB-KW).
GO:0042742;	Biological process: defense response to bacterium (inferred from electronic annotation from UniProtKB-KW).
GO:0019836;	Biological process: hemolysis by symbiont of host red blood cells (inferred from electronic annotation from UniProtKB-KW).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0009405;	Biological process: pathogenesis (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Phylogenomic databases

HOVERGEN

P0C2D5; -.

Other

ProtoNet

P0C2D5.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Antibiotic; Antimicrobial; Apoptosis; Blood coagulation; Cytolysis; Direct protein sequencing; FAD; Flavoprotein; Glycoprotein; Hemolysis; Oxidoreductase; Secreted; Toxin.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 >20`	`>20`	`L-amino-acid oxidase.`	`PRO_0000273570`
`NON_TER`	`20 20`

Sequence information

Length: 20 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 2574 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: 95E97283C86588E7 [This is a checksum on the sequence]

        10         20 
AHDRNPLEEY FRETDYEEFL

P0C2D5 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools