PROTEIN SEQUENCE, FUNCTION, SUBUNIT, AND MASS SPECTROMETRY.
TISSUE=Venom;
DOI=10.1006/abbi.2000.2130; PubMed=11368308 [NCBI, ExPASy, EBI, Israel, Japan]
Ali S.A., Stoeva S., Abbasi A., Alam J.M., Kayed R., Faigle M., Neumeister B., Voelter W.;
"Isolation, structural, and functional characterization of an apoptosis-inducing L-amino acid oxidase from leaf-nosed viper (Eristocophis macmahoni) snake venom.";
Arch. Biochem. Biophys. 384:216-226(2000).

Comments

FUNCTION: Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids. Induces edema and platelet aggregation. Has a potent hemolytic activity. Has an ability to induce apoptosis. Unlike other snake venom L-amino acid oxidases, does not induce hemorrhage. May have an antibacterial activity.
CATALYTIC ACTIVITY: An L-amino acid + H₂O + O₂ = a 2-oxo acid + NH₃ + H₂O₂.
COFACTOR: FAD (By similarity).
SUBUNIT: Homodimer.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed by the venom gland.
PTM: Glycosylated (By similarity).
MASS SPECTROMETRY: Mass=58734.0; Method=MALDI; Range=1-?; Source=PubMed:11368308;.
SIMILARITY: Belongs to the flavin monoamine oxidase family. FIG1 subfamily.

Copyright

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Cross-references

3D structure databases

ModBase

P0C2D3.

Ontologies

GO:0005576;	Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-KW).
GO:0001716;	Molecular function: L-amino-acid oxidase activity (inferred from electronic annotation from EC).
GO:0006915;	Biological process: apoptosis (inferred from electronic annotation from UniProtKB-KW).
GO:0007596;	Biological process: blood coagulation (inferred from electronic annotation from UniProtKB-KW).
GO:0019835;	Biological process: cytolysis (inferred from electronic annotation from UniProtKB-KW).
GO:0042742;	Biological process: defense response to bacterium (inferred from electronic annotation from UniProtKB-KW).
GO:0019836;	Biological process: hemolysis by symbiont of host red blood cells (inferred from electronic annotation from UniProtKB-KW).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0009405;	Biological process: pathogenesis (inferred from electronic annotation from UniProtKB-KW).
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Phylogenomic databases

HOVERGEN

P0C2D3; -.

Other

ProtoNet

P0C2D3.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Antibiotic; Antimicrobial; Apoptosis; Blood coagulation; Cytolysis; Direct protein sequencing; FAD; Flavoprotein; Glycoprotein; Hemolysis; Oxidoreductase; Secreted; Toxin.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 >27`	`>27`	`L-amino-acid oxidase.`	`PRO_0000273568`
`NON_TER`	`27 27`

Sequence information

Length: 27 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 3097 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: 18DBFD66E0655CE7 [This is a checksum on the sequence]

        10         20 
ADDKNPLEEA FREADYEVFL EIAKNGL

P0C2D3 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools