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UniProtKB/Swiss-Prot entry P0C0Q2

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GSEA_STAES
Primary accession number P0C0Q2
Secondary accession numbers Q7DG19 Q8CMC1 Q9AJX0
Integrated into Swiss-Prot on November 22, 2005
Sequence was last modified on November 22, 2005 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 23)
Name and origin of the protein
Protein name Glutamyl endopeptidase [Precursor]
Synonyms EC 3.4.21.19
Glutamic acid-specific protease
GluSE
Gene name
Name: gseA
Synonyms: esp
OrderedLocusNames: SE_1543
From
Staphylococcus epidermidis (strain ATCC 12228) [TaxID: 176280] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Staphylococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1046/j.1365-2958.2003.03671.x; PubMed=12950922 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228).";
Mol. Microbiol. 49:1577-1593(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE015929; AAO05142.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_765098.1; -.
3D structure databases
HSSP P09332; 1DT2. [HSSP ENTRY / PDB]
ModBase P0C0Q2.
Protein family/group databases
MEROPS S01.269; -.
Enzyme and pathway databases
BioCyc SEPI176280:SE_1543-MON; -.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-KW).
GO:0004252; Molecular function: serine-type endopeptidase activity (inferred from electronic annotation from InterPro).
GO:0009405; Biological process: pathogenesis (inferred from electronic annotation from UniProtKB-KW).
GO:0006508; Biological process: proteolysis (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR000126; Pept_S1B_AS.
IPR001254; Peptidase_S1_S6.
IPR008256; Peptidase_S1B.
IPR008353; Peptidase_S1B_tx.
Graphical view of domain structure.
Pfam PF00089; Trypsin; 1.
Pfam graphical view of domain structure.
PRINTS PR01774; EXFOLTOXIN.
PR00839; V8PROTEASE.
PROSITE PS00672; V8_HIS; FALSE_NEG.
PS00673; V8_SER; 1.
Genome annotation databases
GeneID 1055780; -.
GenomeReviews AE015929_GR; SE_1543.
KEGG sep:SE1543; -.
Phylogenomic databases
HOGENOM P0C0Q2; -.
Genome annotation databases
CMR P0C0Q2; SE_1543.
Other
ProtoNet P0C0Q2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Protease; Secreted; Serine protease; Signal; Virulence; Zymogen.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    27  27     Potential. 
PROPEP   28    66  39     By similarity. PRO_0000042921
CHAIN   67   282  216     Glutamyl endopeptidase. PRO_0000042922
ACT_SITE   117   117        Charge relay system (By similarity). 
ACT_SITE   159   159        Charge relay system (By similarity). 
ACT_SITE   235   235        Charge relay system (By similarity). 
Sequence information
Length: 282 AA [This is the length of the unprocessed precursor] Molecular weight: 30809 Da [This is the MW of the unprocessed precursor] CRC64: 5DAD3E8D7EB3E0CB [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKKRFLSICT MTIAALATTT MVNTSYAKTD TESHNHSSLG TENKNVLDIN SSSHNIKPSQ 

        70         80         90        100        110        120 
NKSYPSVILP NNNRHQIFNT TQGHYDAVSF IYIPIDGGYM SGSGVVVGEN EILTNKHVVN 

       130        140        150        160        170        180 
GAKGNPRNIS VHPSAKNEND YPNGKFVGQE IIPYPGNSDL AILRVSPNEH NQHIGQVVKP 

       190        200        210        220        230        240 
ATISSNTDTR INENITVTGY PGDKPLATMW ESVGKVVYIG GEELRYDLST VGGNSGSPVF 

       250        260        270        280 
NGKNQVIGIH YGGVDNKYNS SVYINDFVQQ FLRNNIPDIN IQ
P0C0Q2 in FASTA format

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