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UniProtKB/Swiss-Prot entry P0C0F5


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name UDG_STRP1
Primary accession number P0C0F5
Secondary accession numbers Q07172 Q48W05
Integrated into Swiss-Prot on September 13, 2005
Sequence was last modified on September 13, 2005 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 29)
Name and origin of the protein
Protein name UDP-glucose 6-dehydrogenase
Synonyms UDP-Glc dehydrogenase
UDP-GlcDH
UDPGDH
EC 1.1.1.22
Gene name
Name: hasB
OrderedLocusNames: SPy_2201, M5005_Spy1852
From
Streptococcus pyogenes serotype M1 [TaxID: 301447] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700294 / SF370 / Serotype M1;
DOI=10.1073/pnas.071559398; PubMed=11296296 [NCBI, ExPASy, EBI, Israel, Japan]
Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K., Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P., Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X., Clifton S.W., Roe B.A., McLaughlin R.E.;
"Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
DOI=10.1086/432514; PubMed=16088826 [NCBI, ExPASy, EBI, Israel, Japan]
Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.;
"Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events.";
J. Infect. Dis. 192:771-782(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE004092; AAK34829.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CP000017; AAZ52470.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_270108.1; -.
YP_283215.1; -.
3D structure databases
SMR P0C0F5; 1-402.
ModBase P0C0F5.
Enzyme and pathway databases
BioCyc SPYO160490:SPY2201-MON; -.
SPYO293653:M5005_SPY1852-MON; -.
Ontologies
GO
GO:0051287; Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0003979; Molecular function: UDP-glucose 6-dehydrogenase activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR016040; NAD(P)-bd.
IPR017476; Nucleotide_sugar_DH.
IPR014027; UDP-Glc/GDP-Man_DHase_C.
IPR014026; UDP-Glc/GDP-Man_DHase_dimer.
IPR014028; UDP-Glc/GDP-Man_DHase_dimer-bd.
IPR001732; UDP-Glc/GDP-Man_DHase_N.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:3.40.50.1870; UDP-Glc/GDP-Man_DH_C; 1.
PANTHER PTHR11374; UDPG_MGDP_DH_Creg; 1.
Pfam PF00984; UDPG_MGDP_dh; 1.
PF03720; UDPG_MGDP_dh_C; 1.
PF03721; UDPG_MGDP_dh_N; 1.
Pfam graphical view of domain structure.
Genome annotation databases
GeneID 3571024; -.
901876; -.
GenomeReviews AE004092_GR; SPy_2201.
CP000017_GR; M5005_Spy1852.
KEGG spy:SPy_2201; -.
spz:M5005_Spy_1852; -.
Phylogenomic databases
HOGENOM P0C0F5; -.
Genome annotation databases
CMR P0C0F5; SPy_2201.
Other
ProtoNet P0C0F5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Capsule biogenesis/degradation; Complete proteome; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   402  402     UDP-glucose 6-dehydrogenase. PRO_0000074055
NP_BIND   2    19  18     NAD (Potential). 
ACT_SITE   260   260        By similarity. 
Sequence information
Length: 402 AA [This is the length of the unprocessed precursor] Molecular weight: 45569 Da [This is the MW of the unprocessed precursor] CRC64: 497A4C3C0EF3BA2D [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKIAVAGSGY VGLSLGVLLS LQNEVTIVDI LPSKVDKINN GLSPIQDEYI EYYLKSKQLS 

        70         80         90        100        110        120 
IKATLDSKAA YKEAELVIIA TPTNYNSRIN YFDTQHVETV IKEVLSVNSH ATLIIKSTIP 

       130        140        150        160        170        180 
IGFITEMRQK FQTDRIIFSP EFLRESKALY DNLYPSRIIV SCEENDSPKV KADAEKFALL 

       190        200        210        220        230        240 
LKSAAKKNNV PVLIMGASEA EAVKLFANTY LALRVAYFNE LDTYAESRKL NSHMIIQGIS 

       250        260        270        280        290        300 
YDDRIGMHYN NPSFGYGGYC LPKDTKQLLA NYNNIPQTLI EAIVSSNNVR KSYIAKQIIN 

       310        320        330        340        350        360 
VLEERESPVK VVGVYRLIMK SNSDNFRESA IKDVIDILKS KDIKIIIYEP MLNKLESEDQ 

       370        380        390        400 
SVLVNDLENF KKQANIIVTN RYDNELQDVK NKVYSRDIFN RD 

P0C0F5 in FASTA format

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