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UniProtKB/Swiss-Prot entry P0ABQ3

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GARR_ECOL6
Primary accession number P0ABQ3
Secondary accession number P23523
Integrated into Swiss-Prot on November 8, 2005
Sequence was last modified on November 8, 2005 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 28)
Name and origin of the protein
Protein name 2-hydroxy-3-oxopropionate reductase
Synonyms EC 1.1.1.60
Tartronate semialdehyde reductase
TSAR
Gene name
Name: garR
OrderedLocusNames: c3880
From
Escherichia coli O6 [TaxID: 217992] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=O6:H1 / CFT073 / ATCC 700928 / UPEC;
DOI=10.1073/pnas.252529799; PubMed=12471157 [NCBI, ExPASy, EBI, Israel, Japan]
Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T., Donnenberg M.S., Blattner F.R.;
"Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli.";
Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE014075; AAN82321.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_755747.2; -.
3D structure databases
SMR P0ABQ3; 1-294.
ModBase P0ABQ3.
Ontologies
GO
GO:0008679; Molecular function: 2-hydroxy-3-oxopropionate reductase activity (inferred from electronic annotation from InterPro).
GO:0008442; Molecular function: 3-hydroxyisobutyrate dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0050662; Molecular function: coenzyme binding (inferred from electronic annotation from InterPro).
GO:0004616; Molecular function: phosphogluconate dehydrogenase (decarboxylating) activity (inferred from electronic annotation from InterPro).
GO:0046487; Biological process: glyoxylate metabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006098; Biological process: pentose-phosphate shunt (inferred from electronic annotation from InterPro).
GO:0006573; Biological process: valine metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR002204; 3-OH-isobutyrate_DHase-rel_CS.
IPR015815; 3hydroxyacid_DHase/Rdtase.
IPR006183; 6-phosphogluconate_DHase.
IPR006115; 6PGDH_NAD-bd.
IPR013328; DHase_multihelical.
IPR016040; NAD(P)-bd.
IPR006398; Tartro_sem_red.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.
PANTHER PTHR22981; 3hydroxy_acid_DH; 1.
Pfam PF03446; NAD_binding_2; 1.
Pfam graphical view of domain structure.
PRINTS PR00076; 6PGDHDRGNASE.
TIGRFAMs TIGR01505; tartro_sem_red; 1.
PROSITE PS00895; 3_HYDROXYISOBUT_DH; 1.
Genome annotation databases
GeneID 1040122; -.
GenomeReviews AE014075_GR; c3880.
KEGG ecc:c3880; -.
Phylogenomic databases
HOGENOM P0ABQ3; -.
Genome annotation databases
CMR P0ABQ3; c3880.
Other
ProtoNet P0ABQ3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   294  294     2-hydroxy-3-oxopropionate reductase. PRO_0000173060
ACT_SITE   170   170        By similarity. 
Sequence information
Length: 294 AA [This is the length of the unprocessed precursor] Molecular weight: 30427 Da [This is the MW of the unprocessed precursor] CRC64: 17DA392C2253278C [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKVGFIGLGI MGKPMSKNLL KAGYSLVVAD RNPEAIADVI AAGAETASTA KAIAEQCDVI 

        70         80         90        100        110        120 
ITMLPNSPHV KEVALGENGI IEGAKPGTVL IDMSSIAPLA SREISEALKA KGIDMLDAPV 

       130        140        150        160        170        180 
SGGEPKAIDG TLSVMVGGDK AIFDKYYDLM KAMAGSVVHT GEIGAGNVTK LANQVIVALN 

       190        200        210        220        230        240 
IAAMSEALTL ATKAGVNPDL VYQAIRGGLA GSTVLDAKAP MVMDRNFKPG FRIDLHIKDL 

       250        260        270        280        290 
ANALDTSHGV GAQLPLTAAV MEMMQALRAD GLGTADHSAL ACYYEKLAKV EVTR
P0ABQ3 in FASTA format

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