FUNCTION: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity).
CATALYTIC ACTIVITY: NADPH + NAD⁺ = NADP⁺ + NADH.
SUBUNIT: Heterodimer of an alpha and a beta chain (By similarity).
SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the PNT beta subunit family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE014075; AAN80454.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_753889.1; -.

3D structure databases

HSSP

P11024; 1D4O. [HSSP ENTRY / PDB]

SMR

P0AB68; 296-462.

ModBase

P0AB68.

Ontologies

GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0008750;	Molecular function: NAD(P)+ transhydrogenase (AB-specific) activity (inferred from electronic annotation from InterPro).
GO:0050661;	Molecular function: NADP binding (inferred from electronic annotation from InterPro).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR012136; NADH_DH_b.
IPR004003; NADP_transhyd_b.
Graphical view of domain structure.

Pfam

PF02233; PNTB; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000204; PNTB; 1.

Genome annotation databases

GeneID

1036023; -.

GenomeReviews

AE014075_GR; c1994.

KEGG

ecc:c1994; -.

Phylogenomic databases

HOGENOM

P0AB68; -.

Genome annotation databases

CMR

P0AB68; c1994.

Other

ProtoNet

P0AB68.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell inner membrane; Cell membrane; Complete proteome; Membrane; NAD; NADP; Oxidoreductase; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 462`	`462`	`NAD(P) transhydrogenase subunit beta.`	`PRO_0000199025`
`TOPO_DOM`	`1 3`	`3`	`Periplasmic (Potential).`
`TRANSMEM`	`4 24`	`21`	`Potential.`
`TOPO_DOM`	`25 45`	`21`	`Cytoplasmic (Potential).`
`TRANSMEM`	`46 66`	`21`	`Potential.`
`TOPO_DOM`	`67 82`	`16`	`Periplasmic (Potential).`
`TRANSMEM`	`83 103`	`21`	`Potential.`
`TOPO_DOM`	`104 115`	`12`	`Cytoplasmic (Potential).`
`TRANSMEM`	`116 136`	`21`	`Potential.`
`TOPO_DOM`	`137 164`	`28`	`Periplasmic (Potential).`
`TRANSMEM`	`165 185`	`21`	`Potential.`
`TOPO_DOM`	`186 188`	`3`	`Cytoplasmic (Potential).`
`TRANSMEM`	`189 209`	`21`	`Potential.`
`TOPO_DOM`	`210 215`	`6`	`Periplasmic (Potential).`
`TRANSMEM`	`216 236`	`21`	`Potential.`
`TOPO_DOM`	`237 239`	`3`	`Cytoplasmic (Potential).`
`TRANSMEM`	`240 260`	`21`	`Potential.`
`TOPO_DOM`	`261 308`	`48`	`Periplasmic (Potential).`
`TRANSMEM`	`309 329`	`21`	`Potential.`
`TOPO_DOM`	`330 462`	`133`	`Cytoplasmic (Potential).`

Sequence information

Length: 462 AA [This is the length of the unprocessed precursor]

Molecular weight: 48723 Da [This is the MW of the unprocessed precursor]

CRC64: D11747291D271A2F [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSGGLVTAAY IVAAILFIFS LAGLSKHETS RQGNNFGIAG MAIALIATIF GPDTGNVGWI 

        70         80         90        100        110        120 
LLAMVIGGAI GIRLAKKVEM TEMPELVAIL HSFVGLAAVL VGFNSYLHHD AGMAPILVNI 

       130        140        150        160        170        180 
HLTEVFLGIF IGAVTFTGSV VAFGKLCGKI SSKPLMLPNR HKMNLAALVV SFLLLIVFVR 

       190        200        210        220        230        240 
TDSVGLQVLA LLIMTAIALV FGWHLVASIG GADMPVVVSM LNSYSGWAAA AAGFMLSNDL 

       250        260        270        280        290        300 
LIVTGALVGS SGAILSYIMC KAMNRSFISV IAGGFGTDGS STGDDQEVGE HREITAEETA 

       310        320        330        340        350        360 
ELLKNSHSVI ITPGYGMAVA QAQYPVAEIT EKLRARGINV RFGIHPVAGR LPGHMNVLLA 

       370        380        390        400        410        420 
EAKVPYDIVL EMDEINDDFA DTDTVLVIGA NDTVNPAAQD DPKSPIAGMP VLEVWKAQNV 

       430        440        450        460 
IVFKRSMNTG YAGVQNPLFF KENTHMLFGD AKASVDAILK AL

P0AB68 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools