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UniProtKB/Swiss-Prot entry P0A9Q8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ADHE_ECO57
Primary accession number P0A9Q8
Secondary accession number P17547
Integrated into Swiss-Prot on July 19, 2005
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    December 16, 2008 (Entry version 25)
Name and origin of the protein
Protein name Aldehyde-alcohol dehydrogenase
Synonyms None
Includes Alcohol dehydrogenase
     (ADH)
     (EC 1.1.1.1)
Acetaldehyde dehydrogenase [acetylating]
     (ACDH)
     (EC 1.2.1.10)
Pyruvate-formate-lyase deactivase
     (PFL deactivase)
Gene name
Name: adhE
OrderedLocusNames: Z2016, ECs1741
From
Escherichia coli O157:H7 [TaxID: 83334] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
DOI=10.1038/35054089; PubMed=11206551 [NCBI, ExPASy, EBI, Israel, Japan]
Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A., Blattner F.R.;
"Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
Nature 409:529-533(2001).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
DOI=10.1093/dnares/8.1.11; PubMed=11258796 [NCBI, ExPASy, EBI, Israel, Japan]
Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S., Shiba T., Hattori M., Shinagawa H.;
"Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12.";
DNA Res. 8:11-22(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE005174; AAG56096.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BA000007; BAB35164.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR E90846; E90846.
RefSeq NP_287484.1; -.
NP_309768.1; -.
3D structure databases
ModBase P0A9Q8.
Enzyme and pathway databases
BioCyc ECOL83334:ECS1741-MON; -.
Ontologies
GO
GO:0008774; Molecular function: acetaldehyde dehydrogenase (acetylating) activity (inferred from electronic annotation from InterPro).
GO:0004022; Molecular function: alcohol dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0015976; Biological process: carbon utilization (inferred from electronic annotation from InterPro).
GO:0006066; Biological process: cellular alcohol metabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR015590; Aldehyde_DHase.
IPR012079; Bifunc_Ald/AlcDHase.
IPR001670; Fe_AlcDHase.
Graphical view of domain structure.
Pfam PF00171; Aldedh; 1.
PF00465; Fe-ADH; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000111; ALDH_ADH; 1.
PROSITE PS00913; ADH_IRON_1; 1.
PS00060; ADH_IRON_2; 1.
Genome annotation databases
GeneID 913110; -.
960491; -.
GenomeReviews AE005174_GR; Z2016.
BA000007_GR; ECs1741.
KEGG ece:Z2016; -.
ecs:ECs1741; -.
Phylogenomic databases
HOGENOM P0A9Q8; -.
Genome annotation databases
CMR P0A9Q8; Z2016.
Other
ProtoNet P0A9Q8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Complete proteome; Iron; Multifunctional enzyme; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   891  890     Aldehyde-alcohol dehydrogenase. PRO_0000087838
NP_BIND   422   427  6     NAD (Potential). 
ACT_SITE   246   246        By similarity. 
MOD_RES   358   358        N6-acetyllysine (By similarity). 
Sequence information
Length: 891 AA [This is the length of the unprocessed precursor] Molecular weight: 96127 Da [This is the MW of the unprocessed precursor] CRC64: 75469F57419C8C79 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAVTNVAELN ALVERVKKAQ REYASFTQEQ VDKIFRAAAL AAADARIPLA KMAVAESGMG 

        70         80         90        100        110        120 
IVEDKVIKNH FASEYIYNAY KDEKTCGVLS EDDTFGTITI AEPIGIICGI VPTTNPTSTA 

       130        140        150        160        170        180 
IFKSLISLKT RNAIIFSPHP RAKDATNKAA DIVLQAAIAA GAPKDLIGWI DQPSVELSNA 

       190        200        210        220        230        240 
LMHHPDINLI LATGGPGMVK AAYSSGKPAI GVGAGNTPVV IDETADIKRA VASVLMSKTF 

       250        260        270        280        290        300 
DNGVICASEQ SVVVVDSVYD AVRERFATHG GYLLQGKELK AVQDVILKNG ALNAAIVGQP 

       310        320        330        340        350        360 
AYKIAELAGF SVPENTKILI GEVTVVDESE PFAHEKLSPT LAMYRAKDFE DAVEKAEKLV 

       370        380        390        400        410        420 
AMGGIGHTSC LYTDQDNQPA RVSYFGQKMK TARILINTPA SQGGIGDLYN FKLAPSLTLG 

       430        440        450        460        470        480 
CGSWGGNSIS ENVGPKHLIN KKTVAKRAEN MLWHKLPKSI YFRRGSLPIA LDEVITDGHK 

       490        500        510        520        530        540 
RALIVTDRFL FNNGYADQIT SVLKAAGVET EVFFEVEADP TLSIVRKGAE LANSFKPDVI 

       550        560        570        580        590        600 
IALGGGSPMD AAKIMWVMYE HPETHFEELA LRFMDIRKRI YKFPKMGVKA KMIAVTTTSG 

       610        620        630        640        650        660 
TGSEVTPFAV VTDDATGQKY PLADYALTPD MAIVDANLVM DMPKSLCAFG GLDAVTHAME 

       670        680        690        700        710        720 
AYVSVLASEF SDGQALQALK LLKEYLPASY HEGSKNPVAR ERVHSAATIA GIAFANAFLG 

       730        740        750        760        770        780 
VCHSMAHKLG SQFHIPHGLA NALLICNVIR YNANDNPTKQ TAFSQYDRPQ ARRRYAEIAD 

       790        800        810        820        830        840 
HLGLSAPGDR TAAKIEKLLA WLETLKAELG IPKSIREAGV QEADFLANVD KLSEDAFDDQ 

       850        860        870        880        890 
CTGANPRYPL ISELKQILLD TYYGRDYVEG ETAAKKEAAP AKAEKKAKKS A
P0A9Q8 in FASTA format

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