ID   PPNK_ECOLI              Reviewed;         292 AA.
AC   P0A7B3; P37768; P46140; P77490;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   16-DEC-2008, entry version 38.
DE   RecName: Full=Probable inorganic polyphosphate/ATP-NAD kinase;
DE            Short=Poly(P)/ATP NAD kinase;
DE            EC=2.7.1.23;
GN   Name=ppnK; Synonyms=yfjB, yfjE; OrderedLocusNames=b2615, JW2596;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   MEDLINE=97349980; PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA   Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K.,
RA   Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N.,
RA   Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H.,
RA   Oshima T., Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S.,
RA   Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C.,
RA   Yamagata S., Horiuchi T.;
RT   "Construction of a contiguous 874-kb sequence of the Escherichia coli-
RT   K12 genome corresponding to 50.0-68.8 min on the linkage map and
RT   analysis of its sequence features.";
RL   DNA Res. 4:91-113(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA   Mau B., Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1474(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains
RT   MG1655 and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-163.
RC   STRAIN=B178;
RX   MEDLINE=88319942; PubMed=3045760; DOI=10.1093/nar/16.15.7545;
RA   Lipinska B., King J., Ang D., Georgopoulos C.;
RT   "Sequence analysis and transcriptional regulation of the Escherichia
RT   coli grpE gene, encoding a heat shock protein.";
RL   Nucleic Acids Res. 16:7545-7562(1988).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 194-292.
RC   STRAIN=K12;
RX   MEDLINE=87259985; PubMed=3037486; DOI=10.1093/nar/15.13.5041;
RA   Rostas K., Morton S.J., Picksley S.M., Lloyd R.G.;
RT   "Nucleotide sequence and LexA regulation of the Escherichia coli recN
RT   gene.";
RL   Nucleic Acids Res. 15:5041-5049(1987).
RN   [6]
RP   IDENTIFICATION.
RX   MEDLINE=95075659; PubMed=7984428; DOI=10.1093/nar/22.22.4756;
RA   Borodovsky M., Rudd K.E., Koonin E.V.;
RT   "Intrinsic and extrinsic approaches for detecting genes in a bacterial
RT   genome.";
RL   Nucleic Acids Res. 22:4756-4767(1994).
CC   -!- FUNCTION: Catalyzes the phosphorylation of NAD to NADP. Utilizes
CC       ATP and other nucleoside triphosphates as well as inorganic
CC       polyphosphate as a source of phosphorus (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + NAD(+) = ADP + NADP(+).
CC   -!- COFACTOR: Divalent metal ions (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the NAD kinase family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=X07863; Type=Frameshift; Positions=Several;
CC       Sequence=Y00357; Type=Frameshift; Positions=204, 215, 282;
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DR   EMBL; U36840; AAA79785.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC75664.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA16500.1; -; Genomic_DNA.
DR   EMBL; X07863; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; Y00357; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; B65040; B65040.
DR   RefSeq; AP_003195.1; -.
DR   RefSeq; NP_417105.1; -.
DR   SMR; P0A7B3; 4-292.
DR   GeneID; 947092; -.
DR   GenomeReviews; AP009048_GR; JW2596.
DR   GenomeReviews; U00096_GR; b2615.
DR   KEGG; ecj:JW2596; -.
DR   KEGG; eco:b2615; -.
DR   EchoBASE; EB2109; -.
DR   EcoGene; EG12192; ppnK.
DR   HOGENOM; P0A7B3; -.
DR   BioCyc; EcoCyc:MON0-541; -.
DR   BioCyc; MetaCyc:MON0-541; -.
DR   LinkHub; P0A7B3; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:HAMAP.
DR   GO; GO:0046872; F:metal ion binding; IEA:HAMAP.
DR   GO; GO:0003951; F:NAD+ kinase activity; IEA:HAMAP.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   HAMAP; MF_00361; -; 1.
DR   InterPro; IPR017437; ATP-NAD_kinase_PpnK-typ_all-b.
DR   InterPro; IPR002504; ATP_NADK.
DR   Gene3D; G3DSA:2.60.200.30; ATP-NAD_kinase_PpnK-typ; 1.
DR   PANTHER; PTHR20275; ATP_NADK; 1.
DR   Pfam; PF01513; NAD_kinase; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Kinase; NAD; NADP; Transferase.
FT   CHAIN         1    292       Probable inorganic polyphosphate/ATP-NAD
FT                                kinase.
FT                                /FTId=PRO_0000120616.
SQ   SEQUENCE   292 AA;  32566 MW;  D1E631658408F2E1 CRC64;
     MNNHFKCIGI VGHPRHPTAL TTHEMLYRWL CTKGYEVIVE QQIAHELQLK NVKTGTLAEI
     GQLADLAVVV GGDGNMLGAA RTLARYDIKV IGINRGNLGF LTDLDPDNAQ QQLADVLEGH
     YISEKRFLLE AQVCQQDCQK RISTAINEVV LHPGKVAHMI EFEVYIDEIF AFSQRSDGLI
     ISTPTGSTAY SLSAGGPILT PSLDAITLVP MFPHTLSARP LVINSSSTIR LRFSHRRNDL
     EISCDSQIAL PIQEGEDVLI RRCDYHLNLI HPKDYSYFNT LSTKLGWSKK LF
//