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UniProtKB/Swiss-Prot entry P0A5Y7

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name INHA_MYCBO
Primary accession number P0A5Y7
Secondary accession number P46533
Integrated into Swiss-Prot on March 15, 2005
Sequence was last modified on March 15, 2005 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 28)
Name and origin of the protein
Protein name Enoyl-[acyl-carrier-protein] reductase [NADH]
Synonyms EC 1.3.1.9
NADH-dependent enoyl-ACP reductase
Gene name
Name: inhA
OrderedLocusNames: Mb1520
From
Mycobacterium bovis [TaxID: 1765] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=BCG;
PubMed=8284673 [NCBI, ExPASy, EBI, Israel, Japan]
Banerjee A., Dubnau E., Quemard A., Balasubramanian V., Um K.S., Wilson T., Collins D., de Lisle G., Jacobs W.R. Jr.;
"inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis.";
Science 263:227-230(1994).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=WAG201;
PubMed=7623658 [NCBI, ExPASy, EBI, Israel, Japan]
Wilson T.M., de Lisle G.W., Collins D.M.;
"Effect of inhA and katG on isoniazid resistance and virulence of Mycobacterium bovis.";
Mol. Microbiol. 15:1009-1015(1995).
[3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-935 / AF2122/97;
DOI=10.1073/pnas.1130426100; PubMed=12788972 [NCBI, ExPASy, EBI, Israel, Japan]
Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J., Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
"The complete genome sequence of Mycobacterium bovis.";
Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U41388; AAB60183.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BX248339; CAD96187.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_855172.1; -.
3D structure databases
SMR P0A5Y7; 2-269.
ModBase P0A5Y7.
Ontologies
GO
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0004318; Molecular function: enoyl-[acyl-carrier-protein] reductase (NADH) activity (inferred from electronic annotation from InterPro).
GO:0006633; Biological process: fatty acid biosynthetic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0046677; Biological process: response to antibiotic (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR002198; DHase_sc/Rdtase_SDR.
IPR014358; Enoyl-ACP_rdct.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR19410; ADH_short_C2; 1.
PTHR19410:SF12; Enoyl-ACP_rdct; 1.
Genome annotation databases
GeneID 1092377; -.
GenomeReviews BX248333_GR; Mb1520.
KEGG mbo:Mb1520; -.
Phylogenomic databases
HOGENOM P0A5Y7; -.
Other
BindingDB P0A5Y7; -.
Genome annotation databases
CMR P0A5Y7; Mb1520.
Other
ProtoNet P0A5Y7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Antibiotic resistance; Complete proteome; Fatty acid biosynthesis; Lipid synthesis; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   269  269     Enoyl-[acyl-carrier-protein] reductase [NADH]. PRO_0000054915
NP_BIND   136   165  30     NAD (Potential). 
BINDING   158   158        Substrate (By similarity). 
Sequence information
Length: 269 AA [This is the length of the unprocessed precursor] Molecular weight: 28528 Da [This is the MW of the unprocessed precursor] CRC64: F161D6D6A631CA08 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTGLLDGKRI LVSGIITDSS IAFHIARVAQ EQGAQLVLTG FDRLRLIQRI TDRLPAKAPL 

        70         80         90        100        110        120 
LELDVQNEEH LASLAGRVTE AIGAGNKLDG VVHSIGFMPQ TGMGINPFFD APYADVSKGI 

       130        140        150        160        170        180 
HISAYSYASM AKALLPIMNP GGSIVGMDFD PSRAMPAYNW MTVAKSALES VNRFVAREAG 

       190        200        210        220        230        240 
KYGVRSNLVA AGPIRTLAMS AIVGGALGEE AGAQIQLLEE GWDQRAPIGW NMKDATPVAK 

       250        260 
TVCALLSDWL PATTGDIIYA DGGAHTQLL
P0A5Y7 in FASTA format

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