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UniProtKB/Swiss-Prot entry P0A5S6

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PPNK_MYCTU
Primary accession number P0A5S6
Secondary accession number O33196
Integrated into Swiss-Prot on March 15, 2005
Sequence was last modified on March 15, 2005 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 27)
Name and origin of the protein
Protein name Inorganic polyphosphate/ATP-NAD kinase
Synonyms Poly(P)/ATP NAD kinase
EC 2.7.1.23
Gene name
Name: ppnK
OrderedLocusNames: Rv1695, MT1734
ORFNames: MTCI125.17
From
Mycobacterium tuberculosis [TaxID: 1773] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION.
STRAIN=ATCC 25618 / H37Rv;
DOI=10.1006/bbrc.2000.3433; PubMed=11006082 [NCBI, ExPASy, EBI, Israel, Japan]
Kawai S., Mori S., Mukai T., Suzuki S., Yamada T., Hashimoto W., Murata K.;
"Inorganic polyphosphate / ATP-NAD kinase of Micrococcus flavus and Mycobacterium tuberculosis H37Rv.";
Biochem. Biophys. Res. Commun. 276:57-63(2000).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 25618 / H37Rv;
DOI=10.1038/31159; PubMed=9634230 [NCBI, ExPASy, EBI, Israel, Japan]
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.";
Nature 393:537-544(1998).
[3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CDC 1551 / Oshkosh;
DOI=10.1128/JB.184.19.5479-5490.2002; PubMed=12218036 [NCBI, ExPASy, EBI, Israel, Japan]
Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.";
J. Bacteriol. 184:5479-5490(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB044336; BAB21478.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BX842577; CAB10952.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE000516; AAK46003.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR F70502; F70502.
RefSeq NP_216211.1; -.
NP_336189.1; -.
3D structure databases
PDB
1U0R; X-ray; 2.80 A; A/B/C/D=1-307.[ExPASy / RCSB / EBI]
1U0T; X-ray; 2.30 A; A/B=1-307.[ExPASy / RCSB / EBI]
1Y3H; X-ray; 2.80 A; A/B=1-307.[ExPASy / RCSB / EBI]
1Y3I; X-ray; 2.60 A; A/B=1-307.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1U0R; -.
1U0T; -.
1Y3H; -.
1Y3I; -.
ModBase P0A5S6.
Organism-specific databases
TubercuList Rv1695; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0046872; Molecular function: metal ion binding (inferred from electronic annotation from HAMAP).
GO:0003951; Molecular function: NAD+ kinase activity (inferred from electronic annotation from HAMAP).
GO:0008152; Biological process: metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
HAMAP MF_00361; -; 1.
PBIL [Tree]
InterPro IPR017437; ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504; ATP_NADK.
Graphical view of domain structure.
Gene3D G3DSA:2.60.200.30; ATP-NAD_kinase_PpnK-typ; 1.
PANTHER PTHR20275; ATP_NADK; 1.
Pfam PF01513; NAD_kinase; 1.
Pfam graphical view of domain structure.
Genome annotation databases
GeneID 885660; -.
923972; -.
GenomeReviews AE000516_GR; MT1734.
AL123456_GR; Rv1695.
KEGG mtc:MT1734; -.
mtu:Rv1695; -.
TIGR MT1734; -.
Phylogenomic databases
HOGENOM P0A5S6; -.
Other
ProtoNet P0A5S6.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Complete proteome; Cytoplasm; Kinase; NAD; NADP; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   307  307     Inorganic polyphosphate/ATP-NAD kinase. PRO_0000120635
STRAND   6    14  9      
HELIX   15    18  4      
HELIX   20    30  11      
TURN   31    33  3      
STRAND   35    39  5      
STRAND   79    83  5      
HELIX   85    98  14      
STRAND   102   106  5      
STRAND   115   117  3      
HELIX   118   120  3      
HELIX   121   130  10      
STRAND   134   138  5      
STRAND   141   147  7      
STRAND   150   164  15      
STRAND   166   170  5      
STRAND   172   194  23      
HELIX   197   200  4      
HELIX   202   205  4      
STRAND   218   224  7      
STRAND   226   228  3      
STRAND   233   235  3      
STRAND   241   245  5      
STRAND   252   256  5      
TURN   257   259  3      
STRAND   260   264  5      
STRAND   269   274  6      
STRAND   279   283  5      
HELIX   289   297  9      
Sequence information
Length: 307 AA [This is the length of the unprocessed precursor] Molecular weight: 32904 Da [This is the MW of the unprocessed precursor] CRC64: 68817BE570B6645B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTAHRSVLLV VHTGRDEATE TARRVEKVLG DNKIALRVLS AEAVDRGSLH LAPDDMRAMG 

        70         80         90        100        110        120 
VEIEVVDADQ HAADGCELVL VLGGDGTFLR AAELARNASI PVLGVNLGRI GFLAEAEAEA 

       130        140        150        160        170        180 
IDAVLEHVVA QDYRVEDRLT LDVVVRQGGR IVNRGWALNE VSLEKGPRLG VLGVVVEIDG 

       190        200        210        220        230        240 
RPVSAFGCDG VLVSTPTGST AYAFSAGGPV LWPDLEAILV VPNNAHALFG RPMVTSPEAT 

       250        260        270        280        290        300 
IAIEIEADGH DALVFCDGRR EMLIPAGSRL EVTRCVTSVK WARLDSAPFT DRLVRKFRLP 


VTGWRGK
P0A5S6 in FASTA format

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