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UniProtKB/Swiss-Prot entry P0A5H9

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GGPPS_MYCBO
Primary accession number P0A5H9
Secondary accession number Q50727
Integrated into Swiss-Prot on March 15, 2005
Sequence was last modified on March 15, 2005 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 23)
Name and origin of the protein
Protein name Probable geranylgeranyl pyrophosphate synthetase
Synonyms GGPP synthetase
GGPPSase
Geranylgeranyl diphosphate synthase
Includes Dimethylallyltranstransferase
     (EC 2.5.1.1)
Geranyltranstransferase
     (EC 2.5.1.10)
Farnesyltranstransferase
     (EC 2.5.1.29)
Gene name
OrderedLocusNames: Mb3431c
From
Mycobacterium bovis [TaxID: 1765] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-935 / AF2122/97;
DOI=10.1073/pnas.1130426100; PubMed=12788972 [NCBI, ExPASy, EBI, Israel, Japan]
Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J., Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
"The complete genome sequence of Mycobacterium bovis.";
Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX248346; CAD95619.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_857072.1; -.
3D structure databases
ModBase P0A5H9.
Ontologies
GO
GO:0004161; Molecular function: dimethylallyltranstransferase activity (inferred from electronic annotation from EC).
GO:0004311; Molecular function: farnesyltranstransferase activity (inferred from electronic annotation from EC).
GO:0004337; Molecular function: geranyltranstransferase activity (inferred from electronic annotation from EC).
GO:0008299; Biological process: isoprenoid biosynthetic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR000092; Polyprenyl_synt.
IPR017446; Polyprenyl_synth-rel.
IPR008949; Terpenoid_synth.
Graphical view of domain structure.
Gene3D G3DSA:1.10.600.10; Terpenoid_synth; 1.
PANTHER PTHR12001; Polyprenyl_synt; 1.
Pfam PF00348; polyprenyl_synt; 1.
Pfam graphical view of domain structure.
PROSITE PS00723; POLYPRENYL_SYNTHET_1; 1.
PS00444; POLYPRENYL_SYNTHET_2; 1.
Genome annotation databases
GeneID 1090991; -.
GenomeReviews BX248333_GR; Mb3431c.
KEGG mbo:Mb3431c; -.
Phylogenomic databases
HOGENOM P0A5H9; -.
Genome annotation databases
CMR P0A5H9; Mb3431c.
Other
ProtoNet P0A5H9.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Isoprene biosynthesis; Lipid synthesis; Multifunctional enzyme; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   359  359     Probable geranylgeranyl pyrophosphate synthetase. PRO_0000123969
Sequence information
Length: 359 AA [This is the length of the unprocessed precursor] Molecular weight: 38852 Da [This is the MW of the unprocessed precursor] CRC64: F59F229B19432E6E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRGTDEKYGL PPQPDSDRMT RRTLPVLGLA HELITPTLRQ MADRLDPHMR PVVSYHLGWS 

        70         80         90        100        110        120 
DERGRPVNNN CGKAIRPALV FVAAEAAGAD PHSAIPGAVS VELVHNFSLV HDDLMDRDEH 

       130        140        150        160        170        180 
RRHRPTVWAL WGDAMALLAG DAMLSLAHEV LLDCDSPHVG AALRAISEAT RELIRGQAAD 

       190        200        210        220        230        240 
TAFESRTDVA LDECLKMAEG KTAALMAASA EVGALLAGAP RSVREALVAY GRHIGLAFQL 

       250        260        270        280        290        300 
VDDLLGIWGR PEITGKPVYS DLRSRKKTLP VTWTVAHGGS AGRRLAAWLV DETGSQTASD 

       310        320        330        340        350 
DELAAVAELI ECGGGRRWAS AEARRHVTQG IDMVARIGIP DRPAAELQDL AHYIVDRQA
P0A5H9 in FASTA format

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