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UniProtKB/Swiss-Prot entry P0A4X0

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ADHC_MYCTU
Primary accession number P0A4X0
Secondary accession number P31975
Integrated into Swiss-Prot on March 15, 2005
Sequence was last modified on March 15, 2005 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 20)
Name and origin of the protein
Protein name NADP-dependent alcohol dehydrogenase C
Synonym EC 1.1.1.2
Gene name
Name: adhC
Synonyms: adh
OrderedLocusNames: Rv3045, MT3130
ORFNames: MTV012.60
From
Mycobacterium tuberculosis [TaxID: 1773] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 25618 / H37Rv;
DOI=10.1038/31159; PubMed=9634230 [NCBI, ExPASy, EBI, Israel, Japan]
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.";
Nature 393:537-544(1998).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CDC 1551 / Oshkosh;
DOI=10.1128/JB.184.19.5479-5490.2002; PubMed=12218036 [NCBI, ExPASy, EBI, Israel, Japan]
Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.";
J. Bacteriol. 184:5479-5490(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX842581; CAA16130.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE000516; AAK47460.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR H70860; H70860.
RefSeq NP_217561.1; -.
NP_337646.1; -.
3D structure databases
ModBase P0A4X0.
Organism-specific databases
TubercuList Rv3045; -.
Ontologies
GO
GO:0008106; Molecular function: alcohol dehydrogenase (NADP+) activity (inferred from electronic annotation from EC).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
Graphical view of domain structure.
PANTHER PTHR11695; ADH_Sf_Zn; 1.
Pfam PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.
PROSITE PS00059; ADH_ZINC; 1.
Genome annotation databases
GeneID 888888; -.
923169; -.
GenomeReviews AE000516_GR; MT3130.
AL123456_GR; Rv3045.
KEGG mtc:MT3130; -.
mtu:Rv3045; -.
TIGR MT3130; -.
Phylogenomic databases
HOGENOM P0A4X0; -.
Other
ProtoNet P0A4X0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Metal-binding; NADP; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   346  346     NADP-dependent alcohol dehydrogenase C. PRO_0000160745
METAL   41    41        Zinc 1; catalytic (By similarity). 
METAL   63    63        Zinc 1; catalytic (By similarity). 
METAL   94    94        Zinc 2 (By similarity). 
METAL   97    97        Zinc 2 (By similarity). 
METAL   100   100        Zinc 2 (By similarity). 
METAL   108   108        Zinc 2 (By similarity). 
METAL   158   158        Zinc 1; catalytic (By similarity). 
Sequence information
Length: 346 AA [This is the length of the unprocessed precursor] Molecular weight: 37075 Da [This is the MW of the unprocessed precursor] CRC64: 969179113DBA27C1 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSTVAAYAAM SATEPLTKTT ITRRDPGPHD VAIDIKFAGI CHSDIHTVKA EWGQPNYPVV 

        70         80         90        100        110        120 
PGHEIAGVVT AVGSEVTKYR QGDRVGVGCF VDSCRECNSC TRGIEQYCKP GANFTYNSIG 

       130        140        150        160        170        180 
KDGQPTQGGY SEAIVVDENY VLRIPDVLPL DVAAPLLCAG ITLYSPLRHW NAGANTRVAI 

       190        200        210        220        230        240 
IGLGGLGHMG VKLGAAMGAD VTVLSQSLKK MEDGLRLGAK SYYATADPDT FRKLRGGFDL 

       250        260        270        280        290        300 
ILNTVSANLD LGQYLNLLDV DGTLVELGIP EHPMAVPAFA LALMRRSLAG SNIGGIAETQ 

       310        320        330        340 
EMLNFCAEHG VTPEIELIEP DYINDAYERV LASDVRYRFV IDISAL
P0A4X0 in FASTA format

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