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UniProtKB/Swiss-Prot entry P0A392

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHLE_BACCR
Primary accession number P0A392
Secondary accession number Q59194
Integrated into Swiss-Prot on March 15, 2005
Sequence was last modified on March 15, 2005 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 28)
Name and origin of the protein
Protein name Leucine dehydrogenase
Synonyms LeuDH
EC 1.4.1.9
Gene name
Name: ldh
OrderedLocusNames: BC_4162
From
Bacillus cereus (strain ATCC 14579 / DSM 31) [TaxID: 226900] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus; Bacillus cereus group.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature01582; PubMed=12721630 [NCBI, ExPASy, EBI, Israel, Japan]
Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G., Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C.;
"Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis.";
Nature 423:87-91(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE016877; AAP11078.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_833877.1; -.
3D structure databases
HSSP Q59771; 1C1D. [HSSP ENTRY / PDB]
SMR P0A392; 3-366.
ModBase P0A392.
Enzyme and pathway databases
BioCyc BCER226900:BC_4162-MON; -.
Ontologies
GO
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0050049; Molecular function: leucine dehydrogenase activity (inferred from electronic annotation from EC).
GO:0009083; Biological process: branched chain family amino acid catabolic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR006095; Glu/Leu/Phe/Val_DHase.
IPR006096; Glu/Leu/Phe/Val_DHase_C.
IPR006097; Glu/Leu/Phe/Val_DHase_dimer.
IPR016211; Glu/Phe/Leu/Val_DHase_bac/arc.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00208; ELFV_dehydrog; 1.
PF02812; ELFV_dehydrog_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000188; Phe_leu_dh; 1.
PRINTS PR00082; GLFDHDRGNASE.
PROSITE PS00074; GLFV_DEHYDROGENASE; 1.
Genome annotation databases
GeneID 1206507; -.
GenomeReviews AE016877_GR; BC_4162.
KEGG bce:BC4162; -.
Phylogenomic databases
HOGENOM P0A392; -.
Genome annotation databases
CMR P0A392; BC_4162.
Other
ProtoNet P0A392.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Branched-chain amino acid catabolism; Complete proteome; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   366  366     Leucine dehydrogenase. PRO_0000182801
NP_BIND   182   188  7     NAD (Potential). 
ACT_SITE   82    82        By similarity. 
Sequence information
Length: 366 AA [This is the length of the unprocessed precursor] Molecular weight: 39867 Da [This is the MW of the unprocessed precursor] CRC64: DA84E58062E772AC [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTLEIFEYLE KYDYEQVVFC QDKESGLKAI IAIHDTTLGP ALGGTRMWTY DSEEAAIEDA 

        70         80         90        100        110        120 
LRLAKGMTYK NAAAGLNLGG AKTVIIGDPR KDKSEAMFRA LGRYIQGLNG RYITAEDVGT 

       130        140        150        160        170        180 
TVDDMDIIHE ETDFVTGISP SFGSSGNPSP VTAYGVYRGM KAAAKEAFGT DNLEGKVIAV 

       190        200        210        220        230        240 
QGVGNVAYHL CKHLHAEGAK LIVTDINKEA VQRAVEEFGA SAVEPNEIYG VECDIYAPCA 

       250        260        270        280        290        300 
LGATVNDETI PQLKAKVIAG SANNQLKEDR HGDIIHEMGI VYAPDYVINA GGVINVADEL 

       310        320        330        340        350        360 
YGYNRERALK RVESIYDTIA KVIEISKRDG IATYVAADRL AEERIASLKN SRSTYLRNGH 


DIISRR
P0A392 in FASTA format

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