[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=BS202; Bezborodnikov S.G., Boronin A.M., Tiedje J.M.; "Nucleotide sequences of genes encoding an upper pathway of naphthalene metabolism of NPL1 plasmid from Pseudomonas putida strain BS202."; Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the oxidation of naphthalene dihydrodiol into 1,2-dihydroxynaphthalene (By similarity).
CATALYTIC ACTIVITY: Cis-1,2-dihydronaphthalene-1,2-diol + NAD⁺ = naphthalene-1,2-diol + NADH.
CATALYTIC ACTIVITY: Cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD⁺ = 1,2-dihydroxydibenzothiophene + NADH.
PATHWAY: Aromatic compound metabolism; naphtalene degradation .
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF010471; AAB62709.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P47227; 1BDB. [HSSP ENTRY / PDB]

ModBase

P0A169.

Ontologies

GO:0005488;	Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0018505;	Molecular function: cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity (inferred from electronic annotation from EC).
GO:0018513;	Molecular function: dibenzothiophene dihydrodiol dehydrogenase activity (inferred from electronic annotation from EC).
GO:0019439;	Biological process: aromatic compound catabolic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR002198; DHase_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR19410; ADH_short_C2; 1.

Pfam

PF00106; adh_short; 1.
Pfam graphical view of domain structure.

PRINTS

PR00081; GDHRDH.
PR00080; SDRFAMILY.

PROSITE

PS00061; ADH_SHORT; FALSE_NEG.

Other

ProtoNet

P0A169.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Aromatic hydrocarbons catabolism; NAD; Oxidoreductase; Plasmid.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 259`	`259`	`1,2-dihydroxy-1,2-dihydronaphthalene dehydrogenase.`	`PRO_0000054730`
`NP_BIND`	`8 32`	`25`	`NAD (By similarity).`
`ACT_SITE`	`153 153`		`Proton acceptor (By similarity).`
`BINDING`	`140 140`		`Substrate (By similarity).`

Sequence information

Length: 259 AA [This is the length of the unprocessed precursor]

Molecular weight: 27518 Da [This is the MW of the unprocessed precursor]

CRC64: 187E517F5AA89152 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGNQQVVSIT GAGSGIGLEL VRSFKSAGYY VSALVRNEEQ EALLCKEFKD ALEIVVGDVR 

        70         80         90        100        110        120 
DHATNEKLIK QTIDRFGHLD CFIANAGIWD YMLSIEEPWE KISSSFDEIF DINVKSYFSG 

       130        140        150        160        170        180 
ISAALPELKK TNGSVVMTAS VSSHAVGGGG SCYIASKHAV LGMVKALAYE LAPEVRVNAV 

       190        200        210        220        230        240 
SPGGTVTSLC GSASAGFDKM HMKDMPGIDD MIKGLTPLGF AAKPEDVVAP YLLLASRKQG 

       250 
KFITGTVISI DGGMALGRK

P0A169 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools