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UniProtKB/Swiss-Prot entry P0A086

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MSRA2_STAA8
Primary accession number P0A086
Secondary accession numbers Q2FYK8 Q93P63
Integrated into Swiss-Prot on February 15, 2005
Sequence was last modified on February 15, 2005 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 20)
Name and origin of the protein
Protein name Peptide methionine sulfoxide reductase msrA 2
Synonyms Protein-methionine-S-oxide reductase 2
EC 1.8.4.11
Peptide-methionine (S)-S-oxide reductase 2
Peptide Met(O) reductase 2
Gene name
Name: msrA2
Synonyms: msrA
OrderedLocusNames: SAOUHSC_01432
From
Staphylococcus aureus (strain NCTC 8325) [TaxID: 93061] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Staphylococcus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CATALYTIC ACTIVITY.
PubMed=11700354 [NCBI, ExPASy, EBI, Israel, Japan]
Singh V.K., Moskovitz J., Wilkinson B.J., Jayaswal R.K.;
"Molecular characterization of a chromosomal locus in Staphylococcus aureus that contributes to oxidative defence and is highly induced by the cell-wall-active antibiotic oxacillin.";
Microbiology 147:3037-3045(2001).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
"The Staphylococcus aureus NCTC8325 genome.";
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
[3]
 CATALYTIC ACTIVITY, AND STEREOSPECIFICITY.
DOI=10.1006/bbrc.2001.6171; PubMed=11779133 [NCBI, ExPASy, EBI, Israel, Japan]
Moskovitz J., Singh V.K., Requena J., Wilkinson B.J., Jayaswal R.K., Stadtman E.R.;
"Purification and characterization of methionine sulfoxide reductases from mouse and Staphylococcus aureus and their substrate stereospecificity.";
Biochem. Biophys. Res. Commun. 290:62-65(2002).
Comments
  • FUNCTION: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
  • CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.
  • CATALYTIC ACTIVITY: L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.
  • INDUCTION: Induced by oxacillin but not by hydrogen peroxide.
  • MISCELLANEOUS: Stereospecific for the S isomer of MetO.
  • SIMILARITY: Belongs to the msrA Met sulfoxide reductase family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF349112; AAK83251.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CP000253; ABD30524.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_499957.1; -.
3D structure databases
HSSP P96814; 1NWA. [HSSP ENTRY / PDB]
ModBase P0A086.
Enzyme and pathway databases
BioCyc SAUR93061:SAOUHSC_01432-MON; -.
Ontologies
GO
GO:0008113; Molecular function: peptide-methionine-(S)-S-oxide reductase activity (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006464; Biological process: protein modification process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01401; -; 1.
PBIL [Tree]
InterPro IPR002569; MsrA.
Graphical view of domain structure.
Gene3D G3DSA:3.30.1060.10; MsrA; 1.
Pfam PF01625; PMSR; 1.
Pfam graphical view of domain structure.
ProDom PD003489; PMSR; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00401; msrA; 1.
Genome annotation databases
GeneID 3920213; -.
GenomeReviews CP000253_GR; SAOUHSC_01432.
KEGG sao:SAOUHSC_01432; -.
Phylogenomic databases
HOGENOM P0A086; -.
Genome annotation databases
CMR P0A086; SAOUHSC_01432.
Other
ProtoNet P0A086.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom  To Length Description FTId
CHAIN   1   177  177     Peptide methionine sulfoxide reductase msrA 2. PRO_0000138590
ACT_SITE   12    12        By similarity. 
Sequence information
Length: 177 AA [This is the length of the unprocessed precursor] Molecular weight: 20588 Da [This is the MW of the unprocessed precursor] CRC64: 6BE5ABDE1545A5D4 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTKEYATLAG GCFWCMVKPF TSYPGIKSVV SGYSGGHVDN PTYEQVCTNQ TGHVEAVQIT 

        70         80         90        100        110        120 
FDPEVTSFEN ILDIYFKTFD PTDDQGQFFD RGESYQPVIF YHDEHQKKAA EFKKQQLNEQ 

       130        140        150        160        170 
GIFKKPVITP IKPYKNFYPA EDYHQDYYKK NPVHYYQYQR GSGRKAFIES HWGNQNA
P0A086 in FASTA format

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