[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. DOI=10.1111/j.1432-1033.1995.0439h.x; PubMed=7607213 [NCBI, ExPASy, EBI, Israel, Japan] Wu S.V., Dimaline R., Walsh J.H., Campbell B.J.; "Molecular characterization and physiological regulation of a TATA-less gene encoding chicken gastrin."; Eur. J. Biochem. 230:439-446(1995).
[2]	PROTEIN SEQUENCE OF 41-93. TISSUE=Gastric antrum; DOI=10.1016/0196-9781(92)90095-K; PubMed=1523171 [NCBI, ExPASy, EBI, Israel, Japan] Bjoernskov I., Rehfeld J.F., Johnsen A.H.; "Identification of four chicken gastrins, obtained by processing at post-Phe bonds."; Peptides 13:595-601(1992).
[3]	PROTEIN SEQUENCE OF 58-93. TISSUE=Gastric antrum; DOI=10.1016/0014-5793(86)80920-6; PubMed=3743781 [NCBI, ExPASy, EBI, Israel, Japan] Dimaline R., Young J., Gregory H.; "Isolation from chicken antrum, and primary amino acid sequence of a novel 36-residue peptide of the gastrin/CCK family."; FEBS Lett. 205:318-322(1986).

Comments

FUNCTION: Potent stimulus of gastric acid, but not of pancreatic secretion.
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: Belongs to the gastrin/cholecystokinin family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U25125; AAA65926.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
U25124; AAA65925.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

S65677; S65677.

NP_990731.1; -.

3D structure databases

ModBase

P09859.

Ontologies

GO:0005576;	Cellular component: extracellular region (inferred from electronic annotation from InterPro).
GO:0005179;	Molecular function: hormone activity (inferred from electronic annotation from InterPro).
GO:0007586;	Biological process: digestion (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR001651; Gastrin.
IPR013152; Gastrin_CCK_CS.
Graphical view of domain structure.

Pfam

PF00918; Gastrin; 1.
Pfam graphical view of domain structure.

SMART

SM00029; GASTRIN; 1.
SMART graphical view of domain structure.

PROSITE

PS00259; GASTRIN; 1.

Genome annotation databases

GeneID

396365; -.

KEGG

gga:396365; -.

Phylogenomic databases

HOVERGEN

P09859; -.

Other

ProtoNet

P09859.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amidation; Cleavage on pair of basic residues; Digestion; Direct protein sequencing; Hormone; Secreted; Signal; Sulfation.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 20`	`20`	`Potential.`
`PROPEP`	`21 38`	`18`		`PRO_0000010656`
`PEPTIDE`	`41 93`	`53`	`Gastrin/cholecystokinin-like peptide.`	`PRO_0000010657`
`PROPEP`	`97 105`	`9`		`PRO_0000010658`
`MOD_RES`	`87 87`		`Sulfotyrosine.`
`MOD_RES`	`93 93`		`Phenylalanine amide.`

Sequence information

Length: 105 AA [This is the length of the unprocessed precursor]

Molecular weight: 11625 Da [This is the MW of the unprocessed precursor]

CRC64: 9DB4B005EBD931DC [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKTKVFLGLI LSAAVTACLC RPAAKAPGGS HRPTSSLARR DWPEPPSQEQ QQRFISRFLP 

        70         80         90        100 
HVFAELSDRK GFVQGNGAVE ALHDHFYPDW MDFGRRSTED AADAA

P09859 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools