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UniProtKB/Swiss-Prot entry P09370

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ADH1_DROMO
Primary accession number P09370
Secondary accession numbers Q6UPV9 Q6UPW6 Q6UPX2 Q867T9
Integrated into Swiss-Prot on July 1, 1989
Sequence was last modified on October 14, 2008 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 58)
Name and origin of the protein
Protein name Alcohol dehydrogenase 1
Synonym EC 1.1.1.1
Gene name
Name: Adh1
ORFNames: GI17644
From
Drosophila mojavensis (Fruit fly) [TaxID: 7230] 
Taxonomy Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS THR-187; VAL-189 AND LEU-236.
STRAIN=VRF;
PubMed=3224808 [NCBI, ExPASy, EBI, Israel, Japan]
Atkinson P.W., Mills L.E., Starmer W.T., Sullivan D.T.;
"Structure and evolution of the Adh genes of Drosophila mojavensis.";
Genetics 120:713-723(1988).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS THR-187; VAL-189 AND LEU-236.
STRAIN=VRF;
PubMed=1317314 [NCBI, ExPASy, EBI, Israel, Japan]
Bayer C.A., Curtiss S.W., Weaver J.A., Sullivan D.T.;
"Delineation of cis-acting sequences required for expression of Drosophila mojavensis Adh-1.";
Genetics 131:143-153(1992).
[3]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=MJBC 103.3, MJBC 108.5, MJBC 115.4, MJBC 157.3, MJBC 202.2, MJBC 205.1, MJBC 25.3, MJBC 33.3, MJBC 35.1, MJBC 39.3, MJBC 47.3, MJBC 80, and MJBC 95.1;
PubMed=12586706 [NCBI, ExPASy, EBI, Israel, Japan]
Matzkin L.M., Eanes W.F.;
"Sequence variation of alcohol dehydrogenase (Adh) paralogs in cactophilic Drosophila.";
Genetics 163:181-194(2003).
[4]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ARG-28; PRO-61; THR-71; LYS-76; THR-77; LYS-81; TYR-98; THR-115; ILE-136; ARG-167; THR-187; VAL-189; ALA-203; THR-214; GLN-216 AND LEU-236.
STRAIN=MJS 115, MJS 122, MJS 127, MJS 132, MJS 133, MJS 14, MJS 147.2F, MJS 154, MJS 16F, MJS 36, MJS 58.2, MJS 68, MJS 84, MJS 87, and MJS 93;
DOI=10.1093/molbev/msh019; PubMed=14660699 [NCBI, ExPASy, EBI, Israel, Japan]
Matzkin L.M.;
"Population genetics and geographic variation of alcohol dehydrogenase (Adh) paralogs and glucose-6-phosphate dehydrogenase (G6pd) in Drosophila mojavensis.";
Mol. Biol. Evol. 21:276-285(2004).
[5]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tucson 15081-1352.22;
DOI=10.1038/nature06341; PubMed=17994087 [NCBI, ExPASy, EBI, Israel, Japan]
Drosophila 12 genomes consortium;
"Evolution of genes and genomes on the Drosophila phylogeny.";
Nature 450:203-218(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M37276; AAA28335.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X12536; CAA31055.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY154827; AAN86863.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY154828; AAN86864.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY154829; AAN86865.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY154830; AAN86866.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY154831; AAN86867.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY154832; AAN86868.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY154833; AAN86869.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY154834; AAN86870.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY154835; AAN86871.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY154836; AAN86872.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY154837; AAN86873.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY154838; AAN86874.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY154839; AAN86875.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364493; AAR12927.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364494; AAR12928.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364495; AAR12929.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364496; AAR12930.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364497; AAR12931.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364498; AAR12932.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364499; AAR12933.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364500; AAR12934.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364501; AAR12935.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364502; AAR12936.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364503; AAR12937.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364504; AAR12938.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364505; AAR12939.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364506; AAR12940.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364507; AAR12941.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364508; AAR21255.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364509; AAR21256.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364515; AAR21262.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364522; AAR21269.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CH933807; EDW12372.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S01902; S01902.
RefSeq XP_002002930.1; -.
3D structure databases
HSSP P10807; 1B16. [HSSP ENTRY / PDB]
SMR P09370; 1-254.
ModBase P09370.
Organism-specific databases
FlyBase FBgn0012566; Dmoj\Adh1.
Ontologies
GO
GO:0004022; Molecular function: alcohol dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0006066; Biological process: cellular alcohol metabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR002198; DHase_sc/Rdtase_SDR.
IPR002425; Insect_AlcDHase.
IPR002424; Insect_AlcDHase_fam.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR19410; ADH_short_C2; 1.
Pfam PF00106; adh_short; 1.
Pfam graphical view of domain structure.
PRINTS PR01168; ALCDHDRGNASE.
PR01167; INSADHFAMILY.
PR00080; SDRFAMILY.
PROSITE PS00061; ADH_SHORT; 1.
Genome annotation databases
GeneID 6576953; -.
Other
ProtoNet P09370.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
NAD; Oxidoreductase; Polymorphism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   254  253     Alcohol dehydrogenase 1. PRO_0000054478
NP_BIND   10    33  24     NAD (By similarity). 
ACT_SITE   151   151        Proton acceptor (By similarity). 
BINDING   138   138        Substrate (By similarity). 
VARIANT   28    28  1     K -> R (in strain: MJS 16F, MJS 93, MJS 133 and MJS 147.2F). 
VARIANT   61    61  1     L -> P (in strain: MJS 16F, MJS 93, MJS 133 and MJS 147.2F). 
VARIANT   71    71  1     S -> T (in strain: MJS 16F, MJS 93, MJS 133 and MJS 147.2F). 
VARIANT   76    76  1     Q -> K (in strain: MJS 16F, MJS 93, MJS 133 and MJS 147.2F). 
VARIANT   77    77  1     K -> T (in strain: MJS 16F, MJS 93, MJS 133 and MJS 147.2F). 
VARIANT   81    81  1     Q -> K (in strain: MJS 16F, MJS 93, MJS 133 and MJS 147.2F). 
VARIANT   98    98  1     H -> Y (in strain: MJS 16F and MJS 147.2F). 
VARIANT   115   115  1     I -> T (in strain: MJS 16F, MJS 93, MJS 133 and MJS 147.2F). 
VARIANT   136   136  1     V -> I (in strain: MJS 16F, MJS 93, MJS 133 and MJS 147.2F). 
VARIANT   167   167  1     K -> R (in strain: MJS 16F, MJS 93, MJS 133 and MJS 147.2F). 
VARIANT   187   187  1     P -> T (in strain: MJS 16F, MJS 93, MJS 133, MJS 147.2F and VRF). 
VARIANT   189   189  1     L -> V (in strain: MJS 16F, MJS 93, MJS 133, MJS 147.2F and VRF). 
VARIANT   203   203  1     G -> A (in strain: MJS 16F, MJS 93, MJS 133 and MJS 147.2F). 
VARIANT   214   214  1     S -> T (in strain: MJS 16F, MJS 93, MJS 133 and MJS 147.2F). 
VARIANT   216   216  1     E -> Q (in strain: MJS 16F, MJS 93, MJS 133 and MJS 147.2F). 
VARIANT   236   236  1     V -> L (in strain: MJS 16F, MJS 93, MJS 133, MJS 147.2F and VRF). 
Sequence information
Length: 254 AA [This is the length of the unprocessed precursor] Molecular weight: 27561 Da [This is the MW of the unprocessed precursor] CRC64: 4ECDEF98EB9A99ED [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAIANKNIIF VAGLGGIGFD TSREIVKKGP KNLVILDRIE NPAAIAELKA LNPKVTVTFY 

        70         80         90        100        110        120 
LYDVTVSVAE STKLLQKIFD QLKTVDLLIN GAGILDDHQI ERTIAVNFTG TVNTITAIMS 

       130        140        150        160        170        180 
FWDKRKGGPG GVIANVCSVT GFNAIYQVPV YSASKAAALS FTNSLAKLAP ITGVTAYSIN 

       190        200        210        220        230        240 
PGITKTPLLH KFNSWLDVEP RVGELLLEHP TQTSLECAQN FVKAIEANQN GAIWKVDLGT 

       250 
LEAIEWTKHW DSHI
P09370 in FASTA format

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