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UniProtKB/Swiss-Prot entry P09369

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ADH2_DROMO
Primary accession number P09369
Secondary accession numbers Q6YFE3 Q867G0 Q86LV9
Integrated into Swiss-Prot on July 1, 1989
Sequence was last modified on October 14, 2008 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 58)
Name and origin of the protein
Protein name Alcohol dehydrogenase 2
Synonym EC 1.1.1.1
Gene name
Name: Adh2
ORFNames: GI17643
From
Drosophila mojavensis (Fruit fly) [TaxID: 7230] 
Taxonomy Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS SER-28; THR-92; LEU-112; THR-115; ILE-136; LEU-146; PRO-147; GLN-226 AND LEU-236.
STRAIN=VRF;
PubMed=3224808 [NCBI, ExPASy, EBI, Israel, Japan]
Atkinson P.W., Mills L.E., Starmer W.T., Sullivan D.T.;
"Structure and evolution of the Adh genes of Drosophila mojavensis.";
Genetics 120:713-723(1988).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS SER-28; THR-92; LEU-112; THR-115; ILE-136; LEU-146; PRO-147; GLN-226 AND LEU-236.
STRAIN=VRF;
PubMed=1317314 [NCBI, ExPASy, EBI, Israel, Japan]
Bayer C.A., Curtiss S.W., Weaver J.A., Sullivan D.T.;
"Delineation of cis-acting sequences required for expression of Drosophila mojavensis Adh-1.";
Genetics 131:143-153(1992).
[3]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS SER-28 AND SER-71.
STRAIN=MJBC 103.3, MJBC 108.5, MJBC 115.4, MJBC 157.3, MJBC 202.2, MJBC 205.1, MJBC 25.3, MJBC 33.3, MJBC 35.1, MJBC 39.3, MJBC 47.3, MJBC 80, and MJBC 95.1;
PubMed=12586706 [NCBI, ExPASy, EBI, Israel, Japan]
Matzkin L.M., Eanes W.F.;
"Sequence variation of alcohol dehydrogenase (Adh) paralogs in cactophilic Drosophila.";
Genetics 163:181-194(2003).
[4]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS TYR-98; THR-115; ILE-136 AND LEU-236.
STRAIN=MJS 115, MJS 122, MJS 127, MJS 132, MJS 14, MJS 154, MJS 36, MJS 58.2, MJS 68, MJS 84, and MJS 87;
DOI=10.1093/molbev/msh019; PubMed=14660699 [NCBI, ExPASy, EBI, Israel, Japan]
Matzkin L.M.;
"Population genetics and geographic variation of alcohol dehydrogenase (Adh) paralogs and glucose-6-phosphate dehydrogenase (G6pd) in Drosophila mojavensis.";
Mol. Biol. Evol. 21:276-285(2004).
[5]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tucson 15081-1352.22;
DOI=10.1038/nature06341; PubMed=17994087 [NCBI, ExPASy, EBI, Israel, Japan]
Drosophila 12 genomes consortium;
"Evolution of genes and genomes on the Drosophila phylogeny.";
Nature 450:203-218(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M37276; AAA28334.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X12536; CAA31054.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY154864; AAN86900.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY154865; AAN86901.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY154866; AAN86902.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY154867; AAN86903.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY154868; AAN86904.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY154869; AAN86905.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY154870; AAN86906.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY154871; AAN86907.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY154872; AAN86908.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY154873; AAN86909.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY154874; AAN86910.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY154875; AAN86911.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY154876; AAN86912.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364510; AAR21257.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364511; AAR21258.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364512; AAR21259.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364513; AAR21260.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364514; AAR21261.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364516; AAR21263.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364517; AAR21264.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364518; AAR21265.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364519; AAR21266.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364520; AAR21267.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY364521; AAR21268.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CH933807; EDW12371.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S01901; S01901.
RefSeq XP_002002929.1; -.
3D structure databases
HSSP P10807; 1B16. [HSSP ENTRY / PDB]
SMR P09369; 1-254.
ModBase P09369.
Organism-specific databases
FlyBase FBgn0012567; Dmoj\Adh2.
Ontologies
GO
GO:0004022; Molecular function: alcohol dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0006066; Biological process: cellular alcohol metabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR002198; DHase_sc/Rdtase_SDR.
IPR002425; Insect_AlcDHase.
IPR002424; Insect_AlcDHase_fam.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR19410; ADH_short_C2; 1.
Pfam PF00106; adh_short; 1.
Pfam graphical view of domain structure.
PRINTS PR01168; ALCDHDRGNASE.
PR01167; INSADHFAMILY.
PR00080; SDRFAMILY.
PROSITE PS00061; ADH_SHORT; 1.
Genome annotation databases
GeneID 6576952; -.
Other
ProtoNet P09369.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
NAD; Oxidoreductase; Polymorphism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   254  253     Alcohol dehydrogenase 2. PRO_0000054479
NP_BIND   10    33  24     NAD (By similarity). 
ACT_SITE   151   151        Proton acceptor (By similarity). 
BINDING   138   138        Substrate (By similarity). 
VARIANT   28    28  1     R -> S (in strain: MJBC 95.1 and VRF). 
VARIANT   71    71  1     T -> S (in strain: MJBC 33.3). 
VARIANT   92    92  1     A -> T (in strain: VRF). 
VARIANT   98    98  1     H -> Y (in strain: MJS 115, MJS 122, MJS 127, MJS 132, MJS 14, MJS 154, MJS 36, MJS 58.2, MJS 68, MJS 84 and MJS 87). 
VARIANT   112   112  1     V -> L (in strain: VRF). 
VARIANT   115   115  1     I -> T (in strain: MJS 115, MJS 122, MJS 127, MJS 132, MJS 14, MJS 154, MJS 36, MJS 58.2, MJS 68, MJS 84, MJS 87 and VRF). 
VARIANT   136   136  1     V -> I (in strain: MJS 115, MJS 122, MJS 127, MJS 132, MJS 14, MJS 154, MJS 36, MJS 58.2, MJS 68, MJS 84, MJS 87 and VRF). 
VARIANT   146   146  1     Y -> L (in strain: VRF). 
VARIANT   147   147  1     Q -> P (in strain: VRF). 
VARIANT   226   226  1     E -> Q (in strain: VRF). 
VARIANT   236   236  1     V -> L (in strain: MJS 115, MJS 122, MJS 127, MJS 132, MJS 14, MJS 154, MJS 36, MJS 58.2, MJS 68, MJS 84, MJS 87 and VRF). 
Sequence information
Length: 254 AA [This is the length of the unprocessed precursor] Molecular weight: 27605 Da [This is the MW of the unprocessed precursor] CRC64: DE52DEA5DA7508D2 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAIANKNIIF VAGLGGIGFD TSREIVKRGP KNLVILDRIE NPAAIAELKA LNPKVTVTFY 

        70         80         90        100        110        120 
PYDVTVSVAE TTKLLKTIFD KLKTVDLLIN GAGILDDHQI ERTIAVNFTG TVNTITAIMS 

       130        140        150        160        170        180 
FWDKRKGGPG GVIANVCSVT GFNAIYQVPV YSASKAAALS FTNSLARLAP ITGVTAYSIN 

       190        200        210        220        230        240 
PGITKTTLVH KFNSWLDVEP RVAELLLEHP TQTTLQCAQN FVKAIEANQN GAIWKVDLGT 

       250 
LEAIEWTKHW DSHI
P09369 in FASTA format

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View entry in raw text format (no links)
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