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UniProtKB/Swiss-Prot entry P08734

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ENOA_XENLA
Primary accession number P08734
Secondary accession numbers None
Integrated into Swiss-Prot on August 1, 1988
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 65)
Name and origin of the protein
Protein name Alpha-enolase
Synonyms EC 4.2.1.11
2-phosphoglycerate dehydratase
2-phospho-D-glycerate hydro-lyase
Gene name
Name: eno1
From
Xenopus laevis (African clawed frog) [TaxID: 8355] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3390159 [NCBI, ExPASy, EBI, Israel, Japan]
Segil N., Shrutkowski A., Dworkin M.B., Dworkin-Rastl E.;
"Enolase isoenzymes in adult and developing Xenopus laevis and characterization of a cloned enolase sequence.";
Biochem. J. 251:31-39(1988).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Y00718; CAA68706.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S00463; NOXL.
3D structure databases
HSSP P56252; 1PDZ. [HSSP ENTRY / PDB]
SMR P08734; 2-431.
ModBase P08734.
Ontologies
GO
GO:0000015; Cellular component: phosphopyruvate hydratase complex (inferred from electronic annotation from InterPro).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004634; Molecular function: phosphopyruvate hydratase activity (inferred from electronic annotation from InterPro).
GO:0006096; Biological process: glycolysis (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR000941; Enolase.
Graphical view of domain structure.
PANTHER PTHR11902; Enolase; 1.
Pfam PF00113; Enolase_C; 1.
PF03952; Enolase_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001400; Enolase; 1.
PRINTS PR00148; ENOLASE.
ProDom PD000902; Enolase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01060; eno; 1.
PROSITE PS00164; ENOLASE; 1.
Phylogenomic databases
HOVERGEN P08734; -.
Other
ProtoNet P08734.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Glycolysis; Lyase; Magnesium; Metal-binding.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   434  433     Alpha-enolase. PRO_0000134106
REGION   370   373  4     Substrate binding (By similarity). 
ACT_SITE   210   210        Proton donor (By similarity). 
ACT_SITE   343   343        Proton acceptor (By similarity). 
METAL   245   245        Magnesium (By similarity). 
METAL   293   293        Magnesium (By similarity). 
METAL   318   318        Magnesium (By similarity). 
BINDING   158   158        Substrate (By similarity). 
BINDING   167   167        Substrate (By similarity). 
BINDING   293   293        Substrate (By similarity). 
BINDING   318   318        Substrate (By similarity). 
BINDING   394   394        Substrate (By similarity). 
Sequence information
Length: 434 AA [This is the length of the unprocessed precursor] Molecular weight: 47504 Da [This is the MW of the unprocessed precursor] CRC64: 9126C2F39477E3A4 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSIKNIRARE IFDSRGNPTV EVDLYTCKGL FRAAVPSGAS TGIYEALELR DNDKTRYLGK 

        70         80         90        100        110        120 
GVGRAVKYVN EFLGPALCTQ NLNVVEQEKI DKLMIEMDGT ENKSKFGANA LLGVSLAVCK 

       130        140        150        160        170        180 
AGAAEKGVPL YRHIADLAGN PEVILPVPAF NVINGGSHAG NKLAMQEFMI LPVGADSFKE 

       190        200        210        220        230        240 
AMRIGAEVYH NLKNVIKEKY GKDATNVGDE GGFAPNILEN KEALELLKTA INKAGYPDKI 

       250        260        270        280        290        300 
VIGMDVAASE FYRDGKYDLD FKSPDDPSRY ISPDKLAELY MSFVKNYPVV SIEDPFDQDH 

       310        320        330        340        350        360 
WEAWTKFTAA SGIQVVGDDL TVTNPKRIAK AVEEKACNCL LLKVNQIGTV TESLEACKLA 

       370        380        390        400        410        420 
QSNGWGVMVS HRSGETEDTF IADLVVGLCT GQIKTGAPCR SERLAKYNQL LRIEEELGSK 

       430 
ARFAGKNFRK PVFN
P08734 in FASTA format

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