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UniProtKB/Swiss-Prot entry P08305

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name COX1A_PARDE
Primary accession number P08305
Secondary accession numbers None
Integrated into Swiss-Prot on August 1, 1988
Sequence was last modified on August 1, 1988 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 68)
Name and origin of the protein
Protein name Cytochrome c oxidase subunit 1-alpha
Synonyms EC 1.9.3.1
Cytochrome c oxidase polypeptide I-alpha
Cytochrome aa3 subunit 1-alpha
Gene name
Name: ctaDI
Synonyms: coi
From
Paracoccus denitrificans [TaxID: 266] 
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales; Rhodobacteraceae; Paracoccus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=S1657;
PubMed=16453796 [NCBI, ExPASy, EBI, Israel, Japan]
Raitio M., Jalli T., Saraste M.;
"Isolation and analysis of the genes for cytochrome c oxidase in Paracoccus denitrificans.";
EMBO J. 6:2825-2833(1987).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X05829; CAA29274.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S03809; S03809.
3D structure databases
HSSP P98002; 1QLE. [HSSP ENTRY / PDB]
SMR P08305; 14-540.
ModBase P08305.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0005746; Cellular component: mitochondrial respiratory chain (inferred from electronic annotation from UniProtKB-KW).
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005507; Molecular function: copper ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004129; Molecular function: cytochrome-c oxidase activity (inferred from electronic annotation from EC).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0020037; Molecular function: heme binding (inferred from electronic annotation from InterPro).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from InterPro).
GO:0009060; Biological process: aerobic respiration (inferred from electronic annotation from InterPro).
GO:0022900; Biological process: electron transport chain (inferred from electronic annotation from UniProtKB-KW).
GO:0015992; Biological process: proton transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000883; COX1.
Graphical view of domain structure.
Gene3D G3DSA:1.20.210.10; COX1; 1.
PANTHER PTHR10422; COX1; 1.
Pfam PF00115; COX1; 1.
Pfam graphical view of domain structure.
PRINTS PR01165; CYCOXIDASEI.
PROSITE PS50855; COX1; 1.
PS00077; COX1_CUB; 1.
PROSITE graphical view of domain structure (profiles).
Other
ProtoNet P08305.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell inner membrane; Cell membrane; Copper; Electron transport; Heme; Hydrogen ion transport; Ion transport; Iron; Membrane; Metal-binding; Oxidoreductase; Respiratory chain; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   554  554     Cytochrome c oxidase subunit 1-alpha. PRO_0000183455
TRANSMEM   26    56  31     By similarity. 
TRANSMEM   81   118  38     By similarity. 
TRANSMEM   127   148  22     By similarity. 
TRANSMEM   175   203  29     By similarity. 
TRANSMEM   215   248  34     By similarity. 
TRANSMEM   260   295  36     By similarity. 
TRANSMEM   301   319  19     By similarity. 
TRANSMEM   331   359  29     By similarity. 
TRANSMEM   367   390  24     By similarity. 
TRANSMEM   399   425  27     By similarity. 
TRANSMEM   436   463  28     By similarity. 
TRANSMEM   478   508  31     By similarity. 
METAL   91    91        Iron (heme A axial ligand) (By similarity). 
METAL   273   273        Copper B (By similarity). 
METAL   277   277        Copper B (By similarity). 
METAL   322   322        Copper B (By similarity). 
METAL   323   323        Copper B (By similarity). 
METAL   406   406        Iron (heme A3 axial ligand) (By similarity). 
METAL   408   408        Iron (heme A axial ligand) (By similarity). 
DISULFID   63    77        By similarity. 
CROSSLNK   273   277        1'-histidyl-3'-tyrosine (His-Tyr) (By similarity). 
Sequence information
Length: 554 AA [This is the length of the unprocessed precursor] Molecular weight: 62013 Da [This is the MW of the unprocessed precursor] CRC64: 58AD591FBBDCE794 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSAQISDSIE EKRGFFTRWF MSTNHKDIGV LYLFTAGLAG LISVTLTVYM RMELQHPGVQ 

        70         80         90        100        110        120 
YMCLEGMRLV ADAAAECTPN AHLWNVVVTY HGILMMFFVV IPALFGGFGN YFMPLHIGAP 

       130        140        150        160        170        180 
DMAFPRLNNL SYWLYVCGVS LAIASLLSPG GSDQPGAGVG WVLYPPLSTT EAGYAMDLAI 

       190        200        210        220        230        240 
FAVHVSGATS ILGAINIITT FLNMRAPGMT LFKVPLFAWA VFITAWMILL SLPVLAGGIT 

       250        260        270        280        290        300 
MLLMDRNFGT QFFDPAGGGD PVLYQHILWF FGHPEVYMLI LPGFGIISHV ISTFARKPIF 

       310        320        330        340        350        360 
GYLPMVLAMA AIAFLGFIVW AHHMYTAGMS LTQQTYFQMA TMTIAVPTGI KVFSWIATMW 

       370        380        390        400        410        420 
GGSIEFKTPM LWALAFLFTV GGVTGVVIAQ GSLDRVYHDT YYIVAHFHYV MSLGALFAIF 

       430        440        450        460        470        480 
AGTYYWIGKM SGRQYPEWAG QLHFWMMFIG SNLIFFPQHF LGRQGMPRRY IDYPVEFSYW 

       490        500        510        520        530        540 
NNISSIGAYI SFASFLFFIG IVFYTLFAGK PVNVPNYWNE HADTLEWTLP SPPPEHTFET 

       550 
LPKPEDWDRA QAHR
P08305 in FASTA format

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