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UniProtKB/Swiss-Prot entry P08262

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HEM1_BRAJA
Primary accession number P08262
Secondary accession numbers None
Integrated into Swiss-Prot on August 1, 1988
Sequence was last modified on February 28, 2003 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 69)
Name and origin of the protein
Protein name 5-aminolevulinate synthase
Synonyms EC 2.3.1.37
5-aminolevulinic acid synthase
Delta-aminolevulinate synthase
Delta-ALA synthetase
Gene name
Name: hemA
OrderedLocusNames: bll1200
From
Bradyrhizobium japonicum [TaxID: 375] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Bradyrhizobiaceae; Bradyrhizobium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0378-1119(87)90355-6; PubMed=3609750 [NCBI, ExPASy, EBI, Israel, Japan]
McClung C.R., Somerville J.E., Guerinot M.L., Chelm B.K.;
"Structure of the Bradyrhizobium japonicum gene hemA encoding 5-aminolevulinic acid synthase.";
Gene 54:133-139(1987).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=USDA 110;
DOI=10.1093/dnares/9.6.189; PubMed=12597275 [NCBI, ExPASy, EBI, Israel, Japan]
Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
"Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110.";
DNA Res. 9:189-197(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M16751; AAA26216.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BA000040; BAC46465.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A27478; SYZJAL.
RefSeq NP_767840.1; -.
3D structure databases
HSSP P07912; 1FC4. [HSSP ENTRY / PDB]
ModBase P08262.
Enzyme and pathway databases
BioCyc BJAP224911:BLL1200-MON; -.
Ontologies
GO
GO:0003870; Molecular function: 5-aminolevulinate synthase activity (inferred from electronic annotation from InterPro).
GO:0030170; Molecular function: pyridoxal phosphate binding (inferred from electronic annotation from InterPro).
GO:0016769; Molecular function: transferase activity, transferring nitrogenous groups (inferred from electronic annotation from InterPro).
GO:0006783; Biological process: heme biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR010961; 4pyrrol_synth_NH2levulA_synth.
IPR004839; Aminotrans_I/II.
IPR001917; Aminotrans_II_pyridoxalP_BS.
IPR015421; PyrdxlP-dep_Trfase_major_sub1.
Graphical view of domain structure.
Gene3D G3DSA:3.40.640.10; PyrdxlP-dep_Trfase_major_sub1; 1.
Pfam PF00155; Aminotran_1_2; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01821; 5aminolev_synth; 1.
PROSITE PS00599; AA_TRANSFER_CLASS_2; 1.
Genome annotation databases
GeneID 1049580; -.
GenomeReviews BA000040_GR; bll1200.
KEGG bja:bll1200; -.
NMPDR fig|224911.1.peg.1200; -.
Phylogenomic databases
HOGENOM P08262; -.
Genome annotation databases
CMR P08262; bll1200.
Other
ProtoNet P08262.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acyltransferase; Complete proteome; Heme biosynthesis; Pyridoxal phosphate; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   409  409     5-aminolevulinate synthase. PRO_0000163825
BINDING   247   247        Pyridoxal phosphate (covalent) (Probable). 
CONFLICT   261   261        Q -> R (in Ref. 1; AAA26216). 
Sequence information
Length: 409 AA [This is the length of the unprocessed precursor] Molecular weight: 44574 Da [This is the MW of the unprocessed precursor] CRC64: B21B011EB9542D66 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDYSQFFNSA LDRLHTERRY RVFADLERMA GRFPHAIWHS PKGKRDVVIW CSNDYLGMGQ 

        70         80         90        100        110        120 
HPKVVGAMVE TATRVGTGAG GTRNIAGTHH PLVQLEAELA DLHGKEAALL FTSGYVSNQT 

       130        140        150        160        170        180 
GIATIAKLIP NCLILSDELN HNSMIEGIRQ SGCERQVFRH NDLADLEALL KAAGANRPKL 

       190        200        210        220        230        240 
IACESLYSMD GDVAPLAKIC DLAEKYNAMT YVDEVHAVGM YGPRGGGIAE RDGVMHRIDI 

       250        260        270        280        290        300 
LEGTLAKAFG CLGGYIAANG QIIDAVRSYA PGFIFTTALP PAICSAATAA IKHLKTSSWE 

       310        320        330        340        350        360 
RERHQDRAAR VKAILNAAGL PVMSSDTHIV PLFIGDAEKC KQASDLLLEE HGIYIQPINY 

       370        380        390        400 
PTVAKGSERL RITPSPYHDD GLIDQLAEAL LQVWDRLGLP LKQKSLAAE
P08262 in FASTA format

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