ID   CAH6_SHEEP              Reviewed;         307 AA.
AC   P08060;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1988, sequence version 1.
DT   25-NOV-2008, entry version 61.
DE   RecName: Full=Carbonic anhydrase 6;
DE            EC=4.2.1.1;
DE   AltName: Full=Carbonic anhydrase VI;
DE            Short=CA-VI;
DE   AltName: Full=Carbonate dehydratase VI;
DE   AltName: Full=Secreted carbonic anhydrase;
DE   AltName: Full=Salivary carbonic anhydrase;
GN   Name=CA6;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Saliva;
RX   MEDLINE=88294021; PubMed=3135834; DOI=10.1021/bi00408a023;
RA   Fernley R.T., Wright R.D., Coghlan J.P.;
RT   "Complete amino acid sequence of ovine salivary carbonic anhydrase.";
RL   Biochemistry 27:2815-2820(1988).
CC   -!- FUNCTION: Reversible hydration of carbon dioxide. Its role in
CC       saliva is unknown.
CC   -!- CATALYTIC ACTIVITY: H(2)CO(3) = CO(2) + H(2)O.
CC   -!- COFACTOR: Zinc (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Major constituent of saliva.
CC   -!- SIMILARITY: Belongs to the alpha-carbonic anhydrase family.
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DR   PIR; A29993; A29993.
DR   HSSP; O43570; 1JD0.
DR   HOVERGEN; P08060; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0004089; F:carbonate dehydratase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006730; P:one-carbon compound metabolic process; IEA:InterPro.
DR   InterPro; IPR001148; Euk_COanhd.
DR   Gene3D; G3DSA:3.10.200.10; Euk_COanhd; 1.
DR   PANTHER; PTHR18952; Euk_COanhd; 1.
DR   Pfam; PF00194; Carb_anhydrase; 1.
DR   ProDom; PD000865; Euk_COanhd; 1.
DR   PROSITE; PS00162; ALPHA_CA_1; 1.
DR   PROSITE; PS51144; ALPHA_CA_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Lyase; Metal-binding;
KW   Secreted; Zinc.
FT   CHAIN         1    307       Carbonic anhydrase 6.
FT                                /FTId=PRO_0000077430.
FT   METAL        94     94       Zinc; catalytic (By similarity).
FT   METAL        96     96       Zinc; catalytic (By similarity).
FT   METAL       121    121       Zinc; catalytic (By similarity).
FT   CARBOHYD     50     50       N-linked (GlcNAc...).
FT   CARBOHYD    239    239       N-linked (GlcNAc...).
FT   DISULFID     25    207       Potential.
FT   VARIANT      63     63       V -> M.
FT   VARIANT     297    297       I -> M.
SQ   SEQUENCE   307 AA;  35555 MW;  338682C2D45E5D6C CRC64;
     GHGVEWTYSE GMLDEAHWPL EYPKCGGRRQ SPIDLQMKKV QYNPSLRALN LTGYGLWHGE
     FPVTNNGHTV QISLPSTMSM TTSDGTQYLA KQMHFHWGGA SSEISGSEHT VDGMRYVIEI
     HVVHYNSKYN SYEEAQKEPD GLAVLAALVE VKDYTENAYY SKFISHLEDI RYAGQSTVLR
     GLDIEDMLPG DLRYYYSYLG SLTTPPCTEN VHWFVVADTV KLSKTQVEKL ENSLLNHQNK
     TIQNDYRRTQ PLNHRVVEAN FMSRPHQEYT LASKLHFYLN NIDQTLEYLR RFIEQKIPKR
     KKQENWP
//