[1]	PROTEIN SEQUENCE. TISSUE=Saliva; DOI=10.1021/bi00408a023; PubMed=3135834 [NCBI, ExPASy, EBI, Israel, Japan] Fernley R.T., Wright R.D., Coghlan J.P.; "Complete amino acid sequence of ovine salivary carbonic anhydrase."; Biochemistry 27:2815-2820(1988).

Comments

FUNCTION: Reversible hydration of carbon dioxide. Its role in saliva is unknown.
CATALYTIC ACTIVITY: H₂CO₃ = CO₂ + H₂O.
COFACTOR: Zinc (By similarity).
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Major consistuent of saliva.
SIMILARITY: Belongs to the alpha-carbonic anhydrase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases
PIR	A29993; A29993.
3D structure databases
HSSP	O43570; 1JD0. [HSSP ENTRY / PDB]
ModBase	P08060.
Family and domain databases
InterPro	IPR001148; Euk_COanhd. Graphical view of domain structure.
Gene3D	G3DSA:3.10.200.10; Euk_COanhd; 1.
PANTHER	PTHR18952; Euk_COanhd; 1.
Pfam	PF00194; Carb_anhydrase; 1. Pfam graphical view of domain structure.
ProDom	PD000865; Euk_COanhd; 1. [Domain structure / List of seq. sharing at least 1 domain]
PROSITE	PS00162; ALPHA_CA_1; 1. PS51144; ALPHA_CA_2; 1. PROSITE graphical view of domain structure (profiles).
BLOCKS	P08060.
Phylogenomic databases
HOVERGEN	P08060; -.
Other
ProtoNet	P08060.
UniRef	View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Direct protein sequencing; Glycoprotein; Lyase; Metal-binding; Secreted; Zinc.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 307`	`307`	`Carbonic anhydrase 6.`	`PRO_0000077430`
`METAL`	`94 94`		`Zinc; catalytic (By similarity).`
`METAL`	`96 96`		`Zinc; catalytic (By similarity).`
`METAL`	`121 121`		`Zinc; catalytic (By similarity).`
`CARBOHYD`	`50 50`		`N-linked (GlcNAc...).`
`CARBOHYD`	`239 239`		`N-linked (GlcNAc...).`
`DISULFID`	`25 207`		`Potential.`
`VARIANT`	`63 63`	`1`	`V -> M.`
`VARIANT`	`297 297`	`1`	`I -> M.`

Sequence information

Length: 307 AA [This is the length of the unprocessed precursor]

Molecular weight: 35555 Da [This is the MW of the unprocessed precursor]

CRC64: 338682C2D45E5D6C [This is a checksum on the sequence]

        10         20         30         40         50         60 
GHGVEWTYSE GMLDEAHWPL EYPKCGGRRQ SPIDLQMKKV QYNPSLRALN LTGYGLWHGE 

        70         80         90        100        110        120 
FPVTNNGHTV QISLPSTMSM TTSDGTQYLA KQMHFHWGGA SSEISGSEHT VDGMRYVIEI 

       130        140        150        160        170        180 
HVVHYNSKYN SYEEAQKEPD GLAVLAALVE VKDYTENAYY SKFISHLEDI RYAGQSTVLR 

       190        200        210        220        230        240 
GLDIEDMLPG DLRYYYSYLG SLTTPPCTEN VHWFVVADTV KLSKTQVEKL ENSLLNHQNK 

       250        260        270        280        290        300 
TIQNDYRRTQ PLNHRVVEAN FMSRPHQEYT LASKLHFYLN NIDQTLEYLR RFIEQKIPKR 


KKQENWP

P08060 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools