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UniProtKB/Swiss-Prot entry P07720

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name POLG_TBEVS
Primary accession number P07720
Secondary accession numbers P07721 Q88475 Q88476 Q88477 Q88478 Q88479 Q88877 Q88878 Q88879
Integrated into Swiss-Prot on April 1, 1988
Sequence was last modified on May 1, 1991 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 96)
Name and origin of the protein
Protein name Genome polyprotein
Synonyms None
Contains Protein C
     (Core protein)
     (Capsid protein)
Small envelope protein M
     (Matrix protein)
Envelope protein E
Non-structural protein 1
     (NS1)
Non-structural protein 2A
     (NS2A)
Flavivirin protease NS2B regulatory subunit
Flavivirin protease NS3 catalytic subunit
     (EC 3.4.21.91)
Non-structural protein 4A
     (NS4A)
Non-structural protein 4B
     (NS4B)
RNA-directed RNA polymerase
     (EC 2.7.7.48)
     (NS5)
Gene name None
From
Tick-borne encephalitis virus Far Eastern subtype (strain Sofjin) (SOFV) (Sofjin virus) [TaxID: 11087] 
Taxonomy Viruses; ssRNA positive-strand viruses, no DNA stage; Flaviviridae; Flavivirus; tick-borne encephalitis virus group.
Virus hosts Ixodes persulcatus (Taiga tick) [TaxID: 34615]
Ixodes ricinus (Sheep tick) [TaxID: 34613]
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC RNA].
DOI=10.1016/0042-6822(90)90073-Z; PubMed=2136778 [NCBI, ExPASy, EBI, Israel, Japan]
Pletnev A.G., Yamshchikov V.F., Blinov V.M.;
"Nucleotide sequence of the genome and complete amino acid sequence of the polyprotein of tick-borne encephalitis virus.";
Virology 174:250-263(1990).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-1190.
DOI=10.1093/nar/16.15.7750; PubMed=2970626 [NCBI, ExPASy, EBI, Israel, Japan]
Yamshchikov V.F., Pletnev A.G.;
"Nucleotide sequence of the genome region encoding the structural proteins and the NS1 protein of the tick borne encephalitis virus.";
Nucleic Acids Res. 16:7750-7750(1988).
[3]
 NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-683 AND 777-1002.
DOI=10.1016/0014-5793(86)81160-7; PubMed=3709796 [NCBI, ExPASy, EBI, Israel, Japan]
Pletnev A.G., Yamshchikov V.F., Blinov V.M.;
"Tick-borne encephalitis virus genome. The nucleotide sequence coding for virion structural proteins.";
FEBS Lett. 200:317-321(1986).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X07755; CAA30581.1; -; Genomic_RNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X03870; CAA27500.1; -; Genomic_RNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X03870; CAA27501.1; ALT_SEQ; Genomic_RNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X03870; CAA27502.1; ALT_SEQ; Genomic_RNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X03870; CAA27503.1; ALT_SEQ; Genomic_RNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X03871; CAA27505.1; -; Genomic_RNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A33776; GNWVTB.
3D structure databases
PDB
1K4R; EM; 24.00 A; A/B/C=281-675.[ExPASy / RCSB / EBI]
PDBsum 1K4R; -.
SMR P07720; 281-675.
ModBase P07720.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0019031; Cellular component: viral envelope (inferred from electronic annotation from InterPro).
GO:0019013; Cellular component: viral nucleocapsid (inferred from electronic annotation from UniProtKB-KW).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0008026; Molecular function: ATP-dependent helicase activity (inferred from electronic annotation from InterPro).
GO:0003725; Molecular function: double-stranded RNA binding (inferred from electronic annotation from InterPro).
GO:0003724; Molecular function: RNA helicase activity (inferred from electronic annotation from InterPro).
GO:0003968; Molecular function: RNA-directed RNA polymerase activity (inferred from electronic annotation from InterPro).
GO:0004252; Molecular function: serine-type endopeptidase activity (inferred from electronic annotation from InterPro).
GO:0005198; Molecular function: structural molecule activity (inferred from electronic annotation from InterPro).
GO:0016070; Biological process: RNA metabolic process (inferred from electronic annotation from InterPro).
GO:0006410; Biological process: transcription, RNA-dependent (inferred from electronic annotation from UniProtKB-KW).
GO:0019079; Biological process: viral genome replication (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR014001; DEAD-like_N.
IPR011492; DEAD_Flavivir.
IPR001650; DNA/RNA_helicase_C.
IPR002464; DNA/RNA_helicase_DEAH_CS.
IPR011999; Flav_glyE_cen_dm.
IPR013754; Flav_glyE_dim.
IPR001122; Flavi_capsidC.
IPR000069; Flavi_M.
IPR001157; Flavi_NS1.
IPR000752; Flavi_NS2A.
IPR000487; Flavi_NS2B.
IPR000404; Flavi_NS4A.
IPR001528; Flavi_NS4B.
IPR002535; Flavi_propep.
IPR000336; Flv_glyE_Ig-like.
IPR014412; Gen_Poly_FLV.
IPR014021; Helicase_SF1/SF2_ATP-bd.
IPR001850; Peptidase_S7.
IPR000208; RNA_pol_flaviviral.
IPR007094; RNA_pol_PSvir.
IPR002877; RrmJFtsJ_MeTrfase.
Graphical view of domain structure.
Gene3D G3DSA:2.60.98.10; Flav_glyE_dim; 1.
G3DSA:2.60.40.350; Flv_glyE_Ig-like; 1.
Pfam PF01003; Flavi_capsid; 1.
PF07652; Flavi_DEAD; 1.
PF02832; Flavi_glycop_C; 1.
PF00869; Flavi_glycoprot; 1.
PF01004; Flavi_M; 1.
PF00948; Flavi_NS1; 1.
PF01005; Flavi_NS2A; 1.
PF01002; Flavi_NS2B; 1.
PF01350; Flavi_NS4A; 1.
PF01349; Flavi_NS4B; 1.
PF00972; Flavi_NS5; 1.
PF01570; Flavi_propep; 1.
PF01728; FtsJ; 1.
PF00271; Helicase_C; 1.
PF00949; Peptidase_S7; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF003817; Gen_Poly_FLV; 1.
ProDom PD001496; Flavi_NS1; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00487; DEXDc; 1.
SM00490; HELICc; 1.
SMART graphical view of domain structure.
PROSITE PS00690; DEAH_ATP_HELICASE; FALSE_NEG.
PS51192; HELICASE_ATP_BIND_1; 1.
PS51194; HELICASE_CTER; 1.
PS50507; RDRP_SSRNA_POS; 1.
PROSITE graphical view of domain structure (profiles).
Other
ProtoNet P07720.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; ATP-binding; Capsid protein; Cleavage on pair of basic residues; Complete proteome; Core protein; Envelope protein; Glycoprotein; Helicase; Hydrolase; Membrane; Nucleotide-binding; Nucleotidyltransferase; RNA replication; RNA-directed RNA polymerase; Transferase; Transmembrane; Virion.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom     To Length Description FTId
INIT_MET   1       1        Removed; by host. 
CHAIN   2     112  111     Protein C. PRO_0000037804
PROPEP   113     205  93      PRO_0000037805
CHAIN   206     280  75     Small envelope protein M. PRO_0000037806
CHAIN   281     776  496     Envelope protein E. PRO_0000037807
CHAIN   777   ?1128        Non-structural protein 1. PRO_0000037808
CHAIN   ?1129    1358        Non-structural protein 2A. PRO_0000037809
CHAIN   1359    1489  131     Flavivirin protease NS2B regulatory subunit. PRO_0000037810
CHAIN   1490    2110  621     Flavivirin protease NS3 catalytic subunit. PRO_0000037811
CHAIN   2111    2259  149     Non-structural protein 4A. PRO_0000037812
CHAIN   2260    2510  251     Non-structural protein 4B. PRO_0000037813
CHAIN   2511    3412  902     RNA-directed RNA polymerase. PRO_0000037814
TRANSMEM   101     112  12     Hydrophobic signal sequence (Potential). 
TRANSMEM   247     259  13     Potential. 
TRANSMEM   266     280  15     Potential. 
TRANSMEM   738     751  14     Potential. 
DOMAIN   1675    1831  157     Helicase ATP-binding. 
DOMAIN   1841    2000  160     Helicase C-terminal. 
DOMAIN   3038    3187  150     RdRp catalytic. 
NP_BIND   1688    1695  8     ATP (Potential). 
MOTIF   1779    1782  4     DEAH box. 
ACT_SITE   1543    1543        Charge relay system (By similarity). 
ACT_SITE   1567    1567        Charge relay system (By similarity). 
ACT_SITE   1627    1627        Charge relay system (By similarity). 
CARBOHYD   144     144        N-linked (GlcNAc...) (Potential). 
CARBOHYD   434     434        N-linked (GlcNAc...). 
CARBOHYD   861     861        N-linked (GlcNAc...) (Potential). 
CARBOHYD   983     983        N-linked (GlcNAc...) (Potential). 
CARBOHYD   999     999        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1228    1228        N-linked (GlcNAc...) (Potential). 
CARBOHYD   2447    2447        N-linked (GlcNAc...) (Potential). 
CARBOHYD   2466    2466        N-linked (GlcNAc...) (Potential). 
DISULFID   283     310        By similarity. 
DISULFID   340     396        By similarity. 
DISULFID   354     385        By similarity. 
DISULFID   372     401        By similarity. 
DISULFID   466     570        By similarity. 
DISULFID   587     618        By similarity. 
CONFLICT   381     381        W -> S (in Ref. 3). 
CONFLICT   850     850        E -> D (in Ref. 3). 
HELIX   282     285  4      
STRAND   290     294  5      
STRAND   300     306  7      
STRAND   311     315  5      
STRAND   318     332  15      
STRAND   334     352  19      
HELIX   363     366  4      
STRAND   370     380  11      
HELIX   381     383  3      
STRAND   389     401  13      
STRAND   406     411  6      
TURN   414     416  3      
STRAND   418     425  8      
STRAND   441     446  6      
STRAND   451     455  5      
HELIX   457     459  3      
STRAND   460     467  8      
HELIX   468     470  3      
STRAND   477     482  6      
STRAND   491     496  6      
HELIX   497     501  5      
HELIX   518     521  4      
STRAND   522     524  3      
STRAND   534     536  3      
HELIX   541     547  7      
TURN   548     550  3      
STRAND   553     557  5      
STRAND   560     562  3      
STRAND   567     573  7      
STRAND   591     600  10      
STRAND   602     604  3      
STRAND   606     612  7      
STRAND   616     619  4      
STRAND   622     626  5      
STRAND   636     641  6      
STRAND   643     645  3      
STRAND   651     655  5      
STRAND   658     665  8      
STRAND   668     674  7      
Sequence information
Length: 3412 AA [This is the length of the unprocessed precursor] Molecular weight: 377981 Da [This is the MW of the unprocessed precursor] CRC64: 0F61CE6DCCDC5965 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAGKAILKGK GGGPPRRVSK ETAKKTRQSR VQMPNGLVLM RMMGILWHAV AGTARSPVLK 

        70         80         90        100        110        120 
SFWKSVPLKQ ATAALRKIKK AVSTLMVGLQ RRGKRRSAVD WTGWLLVVVL LGVTLAATVR 

       130        140        150        160        170        180 
KERDGTTVIR AEGKDAATQV RVENGTCVIL ATDMGSWCDD SLTYECVTID QGEEPVDVDC 

       190        200        210        220        230        240 
SCRNVDGVYL EYGRCGKQEG SRTRRSVLIP SHAQGDLTGR GHKWLEGDSL RTHLTRVEGW 

       250        260        270        280        290        300 
VWKNKVLTLA VIAVVWLTVE SVVTRVAVVV VLLCLAPVYA SRCTHLENRD FVTGTQGTTR 

       310        320        330        340        350        360 
VTLVLELGGC VTITAEGKPS MDVWLDSIYQ ENPAKTREYC LHAKLSDTKV AARCPTMGPA 

       370        380        390        400        410        420 
TLAEEHQSGT VCKRDQSDRG WGNHCGLFGK GSIVTCVKAS CEAKKKATGH VYDANKIVYT 

       430        440        450        460        470        480 
VKVEPHTGDY VAANETHSGR KTASFTVSSE RTILTMGDYG DVSLLCRVAS GVDLAQTVIL 

       490        500        510        520        530        540 
ELDKTSEHLP TAWQVHRDWF NDLALPWKHE GAQNWNNAER LVEFGAPHAV KMDVYNLGDQ 

       550        560        570        580        590        600 
TGVLLKSLAG VPVAHIDGTK YHLKSGHVTC EVGLEKLKMK GLTYTMCDKT KFTWKRIPTD 

       610        620        630        640        650        660 
SGHDTVVMEV AFSGTKPCRI PVRAVAHGSP DVNVAMLMTP NPTIENNGGG FIEMQLPPGD 

       670        680        690        700        710        720 
NIIYVGELSH QWFQKGSSIG RVFQKTRKGI ERLTVIGEHA WDFGSTGGFL TSVGKALHTV 

       730        740        750        760        770        780 
LGGAFNSLFG GVGFLPKILV GVVLAWLGLN MRNPTMSMSF LLAGGLVLAM TLGVGADVGC 

       790        800        810        820        830        840 
AVDTERMELR CGEGLVVWRE VSEWYDNYAY YPETLGALAS AIKETFEEGT CGIVPQNRLE 

       850        860        870        880        890        900 
MAMWRSSATE LNLALVEGDA NLTVVVDKLD PTDYRGGIPS LLKKGKDIKV SWKSWGHSMI 

       910        920        930        940        950        960 
WSVPEAPRLF MVGTEGSSEC PLERRKTGVF TVAEFGVGLR TKVFLDFRQE STHECDTGVM 

       970        980        990       1000       1010       1020 
GAAVKNGMAV HTDQSLWMKS VRNDTGTYIV ELLVTDLRNC SWPASHTIDN AEVVDSELFL 

      1030       1040       1050       1060       1070       1080 
PASLAGPRSW YNRIPGYSEQ VKGPWKYSPI RVTREECPGT RVTINADCDK RGASVRSTTE 

      1090       1100       1110       1120       1130       1140 
SGKVIPEWCC RTCTLPPVTF RTGTDCWYAM EIRPVHDQGG LVRSMVVADN GELLSEGGIP 

      1150       1160       1170       1180       1190       1200 
GIVALFVVLE YVIRRRPATG TTAMWGGIVV LALLVTGLVK IESLVRYVVA VGITFHLELG 

      1210       1220       1230       1240       1250       1260 
PEIVALTLLQ AVFELRVGLL SAFALRSNLT VREMVTIYFL LLVLELGLPS EGLGALWKWG 

      1270       1280       1290       1300       1310       1320 
DALAMGALIF RACTAEEKTG VGLLLMALMT QQDLATVHYG LMLFLGVASC CSIWKLIRGH 

      1330       1340       1350       1360       1370       1380 
REQKGLTWIV PLAGLLGGEG SGVRLVAFWE LTVHGRRRSF SEPLTVVGVM LTLASGMIRH 

      1390       1400       1410       1420       1430       1440 
TSQEALCALA VASFLLLMLV LGTRKMQLVA EWSGCVEWHP ELMNEGGEVS LRVRQDSMGN 

      1450       1460       1470       1480       1490       1500 
FHLTELEKEE RVMAFWLLAG LAASAFHWSG ILGVMGLWTL SEMLRTARRS GLVFSGQGGR 

      1510       1520       1530       1540       1550       1560 
ERGDRPFEVK DGVYRIFSPG LLWGQRQVGV GYGSKGVLHT MWHVTRGAAL SIDDAVAGPY 

      1570       1580       1590       1600       1610       1620 
WADVKEDVVC YGGAWSLEEK WKGETVQVHA FPPGRAHEVH QCQPGELLLD TGRRIGAVPI 

      1630       1640       1650       1660       1670       1680 
DLAKGTSGSP ILNSQGVVVG LYGNGLKTNE TYVSSIAQGE AEKSRPNLPP AVTGTGWTAK 

      1690       1700       1710       1720       1730       1740 
GQITVLDMHP GSGKTHRVLP ELIRQCIDRR LRTLVLAPTR VVLKEMERAL NGKRVRFHSP 

      1750       1760       1770       1780       1790       1800 
AVGDQQVGGS IVDVMCHATY VNRRLLPQGR QNWEVAIMDE AHWTDPHSIA ARGHLYTLAK 

      1810       1820       1830       1840       1850       1860 
ENKCALVLMT ATPPGKSEPF PESNGAISSE EKQIPDGEWR DGFDWITEYE GRTAWFVPSS 

      1870       1880       1890       1900       1910       1920 
AKGGIIARTL IQKGKSVICL NSKTFEKDYS RVRDEKPDFV VTTDISEMGA NLDVSRVIDG 

      1930       1940       1950       1960       1970       1980 
RTNIKPEEVD GRVELTGTRR VTTASAAQRR GRVGRQEGRT DEYIYSGQCD DDDSGLVQWK 

      1990       2000       2010       2020       2030       2040 
EAQILLDNIT TLRGPVATFY GPEQDKMPEV AGHFRLTEEK RKHFRHLLTH CDFTPWLAWH 

      2050       2060       2070       2080       2090       2100 
VAANVSSVTS RNWTWEGPEE NTVDEANGDL VTFRSPNGAE RTLRPVWRDA RMFREGRDIR 

      2110       2120       2130       2140       2150       2160 
EFVAYASGRR SFGDVLSGMS GVPELLRHRC VSAMDVFYTL MHEEPGSRAM KMAERDAPEA 

      2170       2180       2190       2200       2210       2220 
FLTVVEMMVL GLATLGVVWC FVVRTSISRM MLGTLVLLAS LALLWAGGVS YGNMAGVALI 

      2230       2240       2250       2260       2270       2280 
FYTLLTVLQP EAGKQRSSDD NKLAYFLLTL CSLAGLVAAN EMGFLEKTKA DLSTVLWSEH 

      2290       2300       2310       2320       2330       2340 
EELRSWEEWT NIDIQPARSW GTYVLVVSLF TPYIIHQLQT KIQQLVNSAV ATGAQAMRDL 

      2350       2360       2370       2380       2390       2400 
GGGAPFFGVA GHVMALGVVS LVGATPTSLV VGVGLAAFHL AIVVSGLEAE LTQRAHKVFF 

      2410       2420       2430       2440       2450       2460 
SAMVRNPMVD GDVINPFGEG EAKPALYERK MSLVLAIVLC LMSVVMNRTV PSTPRLLLWD 

      2470       2480       2490       2500       2510       2520 
WRQRDNCSNQ RRTPFGRCQA CGLSGVVRGS LWGFCPLGHR LWLRASGSRR GGSEGDTLGD 

      2530       2540       2550       2560       2570       2580 
LWKRKLNGCT KEEFFAYRRT GILETERDKA RELLKRGETN MGLAVSRGTA KLAWLEERGY 

      2590       2600       2610       2620       2630       2640 
ATLKGEVVDL GCGRGGWSYY AASRPAVMSV KACAIAGKGH ETPKMVTSLG WNLIKFRAGM 

      2650       2660       2670       2680       2690       2700 
DVFSMQPHRA DTIMCDIGES NPDAVVEGER TRKVILLMEQ WKNRNPTATC VFKALAPYRP 

      2710       2720       2730       2740       2750       2760 
EVTEALHRFQ LQWGGGLVRT PFSRNSTHEM YYSTAITGNI VNSVNIQSRK LLARFGDQRG 

      2770       2780       2790       2800       2810       2820 
PTRVPELDLG VGTRCVVLAE DKVKEKDVQE RISALREQYG ETWHMDREHP YRTWQYWAAT 

      2830       2840       2850       2860       2870       2880 
ACANRVGGAL INGVVKLLSW PWNAREDVVR MAMTDTTAFG QQRVFKEKVD TKAQEPQPGT 

      2890       2900       2910       2920       2930       2940 
KVIMRAVNDW ILERLARKSK PRMCSREEFI AKVKSNAALG AWSDEQNRWS SAKEAVEDPA 

      2950       2960       2970       2980       2990       3000 
FWQLVDEERE RHLAGRCAHC VYNMMGKREK KLGEFGVAKG SRAIWYMWLG SRFLEFEALG 

      3010       3020       3030       3040       3050       3060 
FLNEDHWASR GSSGSGVEGI SLNYLGWHLK GLSTLEGGLF YADDTAGWDT KVTNADLEDE 

      3070       3080       3090       3100       3110       3120 
EQLLRYMEGE HKQLAATIMQ KAYHAKVVKV ARPSRDGGCI MDVITRRDQR GSGQVVTYAL 

      3130       3140       3150       3160       3170       3180 
NTLTNIKVQL IRMMEGEGVI EASDAHNPRL LRVERWLRDH GEERLGRMLV SGDDCVVRPV 

      3190       3200       3210       3220       3230       3240 
DDRFSGALYF LNDMAKTRKD IGEWDHSVGF SNWEEVPFCS HHFHELVMKD GRTLIVPCRD 

      3250       3260       3270       3280       3290       3300 
QDELVGRARV SPGCGRSVRE TACLSKAYGQ MWLLSYFHRR DLRTLGLAIC SAVPVDWVPA 

      3310       3320       3330       3340       3350       3360 
GRTTWSIHAS GAWMTTEDML DVWNRVWILD NPFMHSKEKI AEWRDVPYLP KSHDMLCSSL 

      3370       3380       3390       3400       3410 
VGRKERAEWA KNIWGAVEKV RKMIGQEKFK DYLSCMDRHD LHWESKLESS II
P07720 in FASTA format

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