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UniProtKB/Swiss-Prot entry P07717

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DNLI_BPT3
Primary accession number P07717
Secondary accession numbers None
Integrated into Swiss-Prot on April 1, 1988
Sequence was last modified on April 1, 1988 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 55)
Name and origin of the protein
Protein name DNA ligase
Synonyms EC 6.5.1.1
Polydeoxyribonucleotide synthase [ATP]
Gene name
Name: 1.3
From
Enterobacteria phage T3 (Bacteriophage T3) [TaxID: 10759] 
Taxonomy Viruses; dsDNA viruses, no RNA stage; Caudovirales; Podoviridae; Autographivirinae; T7-like viruses.
Virus host Escherichia coli [TaxID: 562]
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Luria;
DOI=10.1016/0022-2836(87)90261-0; PubMed=3586029 [NCBI, ExPASy, EBI, Israel, Japan]
Schmitt M.P., Beck P.J., Kearney C.A., Spence J.L., Digiovanni D., Condreay J.P., Molineux I.J.;
"Sequence of a conditionally essential region of bacteriophage T3, including the primary origin of DNA replication.";
J. Mol. Biol. 193:479-495(1987).
Comments
  • FUNCTION: DNA ligase, which is expressed in the early stage of lytic development, has been implicated in T7 DNA synthesis and genetic recombination. It may also play a role in T7 DNA repair.
  • CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).
  • SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X17255; CAA35125.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X05031; CAA28700.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S09539; S09539.
RefSeq NP_523305.1; -.
3D structure databases
HSSP P00969; 1A0I. [HSSP ENTRY / PDB]
SMR P07717; 6-336.
ModBase P07717.
Ontologies
GO
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0003910; Molecular function: DNA ligase (ATP) activity (inferred from electronic annotation from InterPro).
GO:0006310; Biological process: DNA recombination (inferred from electronic annotation from InterPro).
GO:0006281; Biological process: DNA repair (inferred from electronic annotation from InterPro).
GO:0006260; Biological process: DNA replication (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR012310; DNA_ligase_A_M.
IPR016059; DNA_ligase_CS.
IPR016306; DNA_ligase_phage.
IPR012340; NA-bd_OB-fold.
Graphical view of domain structure.
Gene3D G3DSA:2.40.50.140; OB_NA_bd_sub; 1.
Pfam PF01068; DNA_ligase_A_M; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001600; DNA_ligase_phage_T3; 1.
PROSITE PS00697; DNA_LIGASE_A1; 1.
PS00333; DNA_LIGASE_A2; 1.
PS50160; DNA_LIGASE_A3; 1.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
GeneID 927441; -.
Other
ProtoNet P07717.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; DNA damage; DNA recombination; DNA repair; DNA replication; Ligase; Nucleotide-binding.
Features
SEVIEWER logo Feature table viewer
KeyFrom  To Length Description FTId
CHAIN   1   346  346     DNA ligase. PRO_0000059597
ACT_SITE   34    34        N6-AMP-lysine intermediate (By similarity). 
Sequence information
Length: 346 AA [This is the length of the unprocessed precursor] Molecular weight: 39351 Da [This is the MW of the unprocessed precursor] CRC64: 896D38E6AB80EE3B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNIFNTNPFK AVSFVESAVK KALETSGYLI ADCKYDGVRG NIVVDNVAEA AWLSRVSKFI 

        70         80         90        100        110        120 
PALEHLNGFD KRWQQLLNDD RCIFPDGFML DGELMVKGVD FNTGSGLLRT KWVKRDNMGF 

       130        140        150        160        170        180 
HLTNVPTKLT PKGREVIDGK FEFHLDPKRL SVRLYAVMPI HIAESGEDYD VQNLLMPYHV 

       190        200        210        220        230        240 
EAMRSLLVEY FPEIEWLIAE TYEVYDMDSL TELYEEKRAE GHEGLIVKDP QGIYKRGKKS 

       250        260        270        280        290        300 
GWWKLKPECE ADGIIQGVNW GTEGLANEGK VIGFSVLLET GRLVDANNIS RALMDEFTSN 

       310        320        330        340 
VKAHGEDFYN GWACQVNYME ATPDGSLRHP SFEKFRGTED NPQEKM
P07717 in FASTA format

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