NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0378-1119(85)90262-8; PubMed=3932128 [NCBI, ExPASy, EBI, Israel, Japan]
Bernan V., Filpula D., Herber W., Bibb M.J., Katz E.;
"The nucleotide sequence of the tyrosinase gene from Streptomyces antibioticus and characterization of the gene product.";
Gene 37:101-110(1985).

Comments

FUNCTION: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.
CATALYTIC ACTIVITY: L-tyrosine + L-dopa + O₂ = L-dopa + dopaquinone + H₂O.
COFACTOR: Binds 2 copper ions per subunit (By similarity).
SIMILARITY: Belongs to the tyrosinase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M11582; AAA88571.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

B23971; B23971.

3D structure databases

HSSP

O61363; 1JS8. [HSSP ENTRY / PDB]

SMR

P07524; 2-272.

ModBase

P07524.

Ontologies

GO:0005507;	Molecular function: copper ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004503;	Molecular function: monophenol monooxygenase activity (inferred from electronic annotation from EC).
GO:0006583;	Biological process: melanin biosynthetic process from tyrosine (inferred from electronic annotation from UniProtKB-KW).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR008922; Di-copper_centre.
IPR002227; Tyrosinase.
Graphical view of domain structure.

Gene3D

G3DSA:1.10.1280.10; Di-copper_centre; 1.

Pfam

PF00264; Tyrosinase; 1.
Pfam graphical view of domain structure.

PRINTS

PR00092; TYROSINASE.

PROSITE

PS00497; TYROSINASE_1; 1.
PS00498; TYROSINASE_2; 1.

Other

ProtoNet

P07524.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Copper; Melanin biosynthesis; Metal-binding; Monooxygenase; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed.`
`CHAIN`	`2 273`	`272`	`Tyrosinase.`	`PRO_0000186737`
`METAL`	`38 38`		`Copper A (By similarity).`
`METAL`	`54 54`		`Copper A (By similarity).`
`METAL`	`63 63`		`Copper A (By similarity).`
`METAL`	`190 190`		`Copper B (By similarity).`
`METAL`	`194 194`		`Copper B (By similarity).`
`METAL`	`216 216`		`Copper B (By similarity).`

Sequence information

Length: 273 AA [This is the length of the unprocessed precursor]

Molecular weight: 30739 Da [This is the MW of the unprocessed precursor]

CRC64: FF22A3701AF975BA [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTVRKNQASL TAEEKRRFVA ALLELKRTGR YDAFVTTHNA FILGDTDNGE RTGHRSPSFL 

        70         80         90        100        110        120 
PWHRRFLLEF ERALQSVDAS VALPYWDWSA DRSTRSSLWA PDFLGGTGRS RDGQVMDGPF 

       130        140        150        160        170        180 
AASAGNWPIN VRVDGRTFLR RALGAGVSEL PTRAEVDSVL AMATYDMAPW NSGSDGFRNH 

       190        200        210        220        230        240 
LEGWRGVNLH NRVHVWVGGQ MATGVSPNDP VFWLHHAYID KLWAEWQRRH PSSPYLPGGG 

       250        260        270 
TPNVVDLNET MKPWNDTTPA ALLDHTRHYT FDV

P07524 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools