ID   GRP_HUMAN               Reviewed;         148 AA.
AC   P07492; P07491; P81553; Q14454; Q9BSY7;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   16-DEC-2008, entry version 86.
DE   RecName: Full=Gastrin-releasing peptide;
DE            Short=GRP;
DE   Contains:
DE     RecName: Full=Neuromedin-C;
DE     AltName: Full=GRP-10;
DE   Flags: Precursor;
GN   Name=GRP;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ALTERNATIVE SPLICING.
RX   MEDLINE=86094341; PubMed=3001723;
RA   Spindel E.R., Zilberberg M.D., Habener J.F., Chin W.W.;
RT   "Two prohormones for gastrin-releasing peptide are encoded by two
RT   mRNAs differing by 19 nucleotides.";
RL   Proc. Natl. Acad. Sci. U.S.A. 83:19-23(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND AMIDATION AT MET-50.
RX   MEDLINE=89096899; PubMed=3211139;
RA   Lebacq-Verheyden A.-M., Kasprzyk P.G., Raum M.G.,
RA   van Wyke Coelingh K., Lebacq J.A., Battey J.F.;
RT   "Posttranslational processing of endogenous and of baculovirus-
RT   expressed human gastrin-releasing peptide precursor.";
RL   Mol. Cell. Biol. 8:3129-3135(1988).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE SPLICING.
RX   MEDLINE=86111953; PubMed=3003116;
RA   Sausville E.A., Lebacq-Verheyden A.-M., Spindel E.R., Cuttitta F.,
RA   Gazdar A.F., Battey J.F.;
RT   "Expression of the gastrin-releasing peptide gene in human small cell
RT   lung cancer. Evidence for alternative processing resulting in three
RT   distinct mRNAs.";
RL   J. Biol. Chem. 261:2451-2457(1986).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ARG-4.
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: GRP stimulates gastrin release as well as other
CC       gastrointestinal hormones. Operates as a negative feedback
CC       regulating fear and established a causal relationship between GRP-
CC       receptor gene expression, long-term potentiation, and amygdala-
CC       dependent memory for fear (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=P07492-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P07492-2; Sequence=VSP_000549;
CC       Name=3;
CC         IsoId=P07492-3; Sequence=VSP_000550;
CC   -!- SIMILARITY: Belongs to the bombesin/neuromedin-B/ranatensin
CC       family.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Gastrin-releasing peptide
CC       entry;
CC       URL="http://en.wikipedia.org/wiki/Gastrin_releasing_peptide";
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; K02054; AAA52613.1; -; mRNA.
DR   EMBL; M12550; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; M12512; AAA52612.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; M12511; AAA52612.1; JOINED; Genomic_DNA.
DR   EMBL; M12512; AAA52611.1; -; Genomic_DNA.
DR   EMBL; M12511; AAA52611.1; JOINED; Genomic_DNA.
DR   EMBL; BC004488; AAH04488.1; -; mRNA.
DR   PIR; A26182; A26182.
DR   PIR; B26182; B26182.
DR   RefSeq; NP_001012530.1; -.
DR   RefSeq; NP_001012531.1; -.
DR   RefSeq; NP_002082.2; -.
DR   UniGene; Hs.153444; -.
DR   Ensembl; ENSG00000134443; Homo sapiens.
DR   GeneID; 2922; -.
DR   KEGG; hsa:2922; -.
DR   GeneCards; GC18P055038; -.
DR   HGNC; HGNC:4605; GRP.
DR   HPA; HPA007314; -.
DR   MIM; 137260; gene.
DR   PharmGKB; PA24627; -.
DR   HOGENOM; P07492; -.
DR   HOVERGEN; P07492; -.
DR   NextBio; 11585; -.
DR   ArrayExpress; P07492; -.
DR   CleanEx; HS_GRP; -.
DR   GermOnline; ENSG00000134443; Homo sapiens.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IDA:MGI.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IDA:MGI.
DR   InterPro; IPR000874; Bombesin.
DR   InterPro; IPR015674; Gastrin-RP.
DR   PANTHER; PTHR16866; Gastrin-RP; 1.
DR   Pfam; PF02044; Bombesin; 1.
DR   PROSITE; PS00257; BOMBESIN; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Amidation; Cleavage on pair of basic residues;
KW   Polymorphism; Secreted; Signal.
FT   SIGNAL        1     23
FT   PEPTIDE      24     50       Gastrin-releasing peptide.
FT                                /FTId=PRO_0000003035.
FT   PEPTIDE      41     50       Neuromedin-C.
FT                                /FTId=PRO_0000003036.
FT   PROPEP       54    148
FT                                /FTId=PRO_0000003037.
FT   MOD_RES      50     50       Methionine amide.
FT   VAR_SEQ     122    148       VGSKGKVGRLSAPGSQREGRNPQLNQQ -> LVDSLLQVLN
FT                                VKEGTPS (in isoform 2).
FT                                /FTId=VSP_000549.
FT   VAR_SEQ     128    134       Missing (in isoform 3).
FT                                /FTId=VSP_000550.
FT   VARIANT       4      4       S -> R (in dbSNP:rs1062557).
FT                                /FTId=VAR_027834.
SQ   SEQUENCE   148 AA;  16144 MW;  2B55B93904825466 CRC64;
     MRGSELPLVL LALVLCLAPR GRAVPLPAGG GTVLTKMYPR GNHWAVGHLM GKKSTGESSS
     VSERGSLKQQ LREYIRWEEA ARNLLGLIEA KENRNHQPPQ PKALGNQQPS WDSEDSSNFK
     DVGSKGKVGR LSAPGSQREG RNPQLNQQ
//