Cavia cutleri (Guinea pig) [TaxID: 10144]
Cricetidae sp. (Hamster) [TaxID: 36483]
Mus musculus (Mouse) [TaxID: 10090]
Rattus norvegicus (Rat) [TaxID: 10116]

Protein existence

3: Inferred from homology;

References

[1]

NUCLEOTIDE SEQUENCE [GENOMIC RNA].
DOI=10.1016/0092-8674(85)90080-7; PubMed=2986845 [NCBI, ExPASy, EBI, Israel, Japan]
Blumberg B.M., Giorgi C., Roux L., Raju R., Dowling P., Chollet A., Kolakofsky D.;
"Sequence determination of the Sendai virus HN gene and its comparison to the influenza virus glycoproteins.";
Cell 41:269-278(1985).

Comments

FUNCTION: Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).
FUNCTION: Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins (By similarity).
CATALYTIC ACTIVITY: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
SUBUNIT: Homotetramer; composed of disulfide-linked homodimers. Interacts with F protein trimer (By similarity).
SUBCELLULAR LOCATION: Virion membrane; Single-pass type II membrane protein (Potential). Cell membrane; Single-pass type II membrane protein (Potential). Note=Folded in the endoplasmic reticulum (By similarity).
PTM: N-glycosylated; glycans consist of a mixture of high mannose-type oligosaccharides and of complex-type oligosaccharides (By similarity).
SIMILARITY: Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M12397; AAA47810.1; -; Genomic_RNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A00877; HNNZS.

3D structure databases

ModBase

P03425.

Ontologies

GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0019031;	Cellular component: viral envelope (inferred from electronic annotation from InterPro).
GO:0055036;	Cellular component: virion membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0004308;	Molecular function: exo-alpha-sialidase activity (inferred from electronic annotation from InterPro).
GO:0046789;	Molecular function: host cell surface receptor binding (inferred from electronic annotation from InterPro).
GO:0019058;	Biological process: viral infectious cycle (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR000665; Hemagglutn-neuramid_glycoprot.
IPR016285; Hemagglutn-neuramid_paramyxo.
Graphical view of domain structure.

Pfam

PF00423; HN; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF001072; Hemagglut-neuramid_paramyxoV; 1.

Other

ProtoNet

P03425.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell membrane; Envelope protein; Glycoprotein; Hemagglutinin; Hydrolase; Membrane; Signal-anchor; Transmembrane; Virion.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 576`	`576`	`Hemagglutinin-neuraminidase.`	`PRO_0000142638`
`TOPO_DOM`	`1 37`	`37`	`Cytoplasmic (By similarity).`
`TRANSMEM`	`38 58`	`21`	`By similarity.`
`TOPO_DOM`	`59 576`	`518`	`Extracellular (By similarity).`
`REGION`	`10 14`	`5`	`Incorporation in virion (By similarity).`
`REGION`	`59 140`	`82`	`Involved in interaction with F protein (By similarity).`
`CARBOHYD`	`77 77`		`N-linked (GlcNAc...) (By similarity).`
`CARBOHYD`	`499 499`		`N-linked (GlcNAc...) (By similarity).`
`CARBOHYD`	`511 511`		`N-linked (GlcNAc...) (By similarity).`
`DISULFID`	`129 129`		`Interchain (Potential).`

Sequence information

Length: 576 AA [This is the length of the unprocessed precursor]

Molecular weight: 63515 Da [This is the MW of the unprocessed precursor]

CRC64: 01CD8067E038FC5B [This is a checksum on the sequence]

        10         20         30         40         50         60 
MDGDRGKRDS YWSTSPSGST TKLASGWERS SKVDTWLLIL SFTQWALSIA TVIICIIISA 

        70         80         90        100        110        120 
RQGYSTKEYS MTVEALNMSS REVKESLTSL IRQEVIARAV NIQSSVQTGI PVLLNKNSRD 

       130        140        150        160        170        180 
VIQMIDKSCS RQELTQLCES TIAVHHAEGI APLEPHSFWR CPVGEPYLSS DPKISLLLGP 

       190        200        210        220        230        240 
SLLSGSTTIS GCVRLPSLSI GEAIYAYSSN LITQGCADIG KSYQVLQLGY ISLNSDMFPD 

       250        260        270        280        290        300 
LNPVVSHTYD INDNRKSCSV VATGTRGYQL CSMPTVDERT DYSSDGIEDL VLDVLDLKGS 

       310        320        330        340        350        360 
TKSHRYRNSE VDLDHPFSAL YPSVGNGIAT EGSLIFLGYG GLTTPLQGDT KCRTQGCQQV 

       370        380        390        400        410        420 
SQDTCNEALK ITWLGGKQVV NVIIRVNDYL SERPKIRVTT IPITQNYLGA EGRLLKLGDR 

       430        440        450        460        470        480 
VYIYTRSSGW HSQLQIGVLD VSHPLTINWT PHEALSRPGN KECNWYNTCP KECISGVYTD 

       490        500        510        520        530        540 
AYPLSPDAAN VATVTLYANT SRVNPTIMYS NTTNIINMLR IKDVQLEVAY TTISSCITHF 

       550        560        570 
GKGYCFHIIE INQKSLNTLQ PMLFKTSIPK LCKAES

P03425 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools