[1]	PROTEIN SEQUENCE OF 2-175. PubMed=4674126 [NCBI, ExPASy, EBI, Israel, Japan] Croft L.R.; "The amino acid sequence of gamma-crystallin (fraction II) from calf lens."; Biochem. J. 128:961-970(1972).

Comments

FUNCTION: Crystallins are the dominant structural components of the vertebrate eye lens.
DOMAIN: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
SIMILARITY: Belongs to the beta/gamma-crystallin family.
SIMILARITY: Contains 4 beta/gamma crystallin 'Greek key' domains.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

3D structure databases
HSSP	P02526; 1DSL. [HSSP ENTRY / PDB]
SMR	P02527; 2-175.
ModBase	P02527.
Family and domain databases
InterPro	IPR001064; Crystallin. Graphical view of domain structure.
Gene3D	G3DSA:2.60.20.10; Crystallin; 2.
Pfam	PF00030; Crystall; 2. Pfam graphical view of domain structure.
PRINTS	PR01367; BGCRYSTALLIN.
SMART	SM00247; XTALbg; 2. SMART graphical view of domain structure.
PROSITE	PS50915; CRYSTALLIN_BETA_GAMMA; 4. PROSITE graphical view of domain structure (profiles).
BLOCKS	P02527.
Phylogenomic databases
HOVERGEN	P02527; -.
Other
ProtoNet	P02527.
UniRef	View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Direct protein sequencing; Eye lens protein; Repeat.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed.`
`CHAIN`	`2 175`	`174`	`Gamma-crystallin A.`	`PRO_0000057580`
`DOMAIN`	`2 40`	`39`	`Beta/gamma crystallin 'Greek key' 1.`
`DOMAIN`	`41 83`	`43`	`Beta/gamma crystallin 'Greek key' 2.`
`DOMAIN`	`89 129`	`41`	`Beta/gamma crystallin 'Greek key' 3.`
`DOMAIN`	`130 172`	`43`	`Beta/gamma crystallin 'Greek key' 4.`
`REGION`	`84 88`	`5`	`Connecting peptide.`

Sequence information

Length: 175 AA [This is the length of the unprocessed precursor]

Molecular weight: 21135 Da [This is the MW of the unprocessed precursor]

CRC64: 612258034CBF5BDF [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGKITFYEDR GFQGHCYQCS SNNCLQQPYF SRCNSIRVDV HSWFVYQRPD YRGHQYMLQR 

        70         80         90        100        110        120 
GNYPQYGQWM GFDDSIRSCR LIPQHTGTFR MRIYERDDFR GQMSEITDDC PSLQDRFHLT 

       130        140        150        160        170 
EVNSVRVLEG SWVIYEMPSY RGRQYLLRPG EYRRYLDWGA MNAKVGSLRR VMDFY

P02527 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools