[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
TISSUE=Fetal lung;
PubMed=9858585 [NCBI, ExPASy, EBI, Israel, Japan]
Gudas J.M.,
Payton M.,
Thukral S.,
Chen E.,
Bass M.,
Robinson M.O.,
Coats S.;
"Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers.";
Mol. Cell. Biol. 19:612-622(1999).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=B-cell;
DOI=10.1038/sj.onc.1202477; PubMed=9840927 [NCBI, ExPASy, EBI, Israel, Japan]
Lauper N.,
Beck A.R.P.,
Cariou S.,
Richman L.,
Hofmann K.,
Reith W.,
Slingerland J.M.,
Amati B.;
"Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle.";
Oncogene 17:2637-2643(1998).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND MUTAGENESIS OF THR-392.
TISSUE=Keratinocyte;
DOI=10.1038/sj.onc.1202505; PubMed=9840943 [NCBI, ExPASy, EBI, Israel, Japan]
Zariwala M.,
Liu J.,
Xiong Y.;
"Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins.";
Oncogene 17:2787-2798(1998).
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[4]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT SER-387.
NIEHS SNPs program;
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
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[5]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21; SER-383 AND THR-392, AND MASS SPECTROMETRY.
DOI=10.1016/j.molcel.2008.07.007; PubMed=18691976 [NCBI, ExPASy, EBI, Israel, Japan]
Daub H.,
Olsen J.V.,
Bairlein M.,
Gnad F.,
Oppermann F.S.,
Korner R.,
Greff Z.,
Keri G.,
Stemmann O.,
Mann M.;
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.";
Mol. Cell 31:438-448(2008).
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[6]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N.,
Zhou C.,
Villen J.,
Beausoleil S.A.,
Bakalarski C.E.,
Elledge S.J.,
Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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- FUNCTION: Essential for the control of the cell cycle at the late G1 and early S phase.
- SUBUNIT: Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.
- INTERACTION:
P24941:CDK2; NbExp=5; IntAct=EBI-375033, EBI-375096;
P38936:CDKN1A; NbExp=1; IntAct=EBI-375033, EBI-375077;
P46527:CDKN1B; NbExp=1; IntAct=EBI-375033, EBI-519280;
Q9UBD5:ORC3L; NbExp=1; IntAct=EBI-375033, EBI-374916;
- SUBCELLULAR LOCATION: Nucleus.
- ALTERNATIVE PRODUCTS:
2 named isoforms [FASTA] produced by alternative splicing.
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| Name | Short |
| Synonyms | SV |
| Isoform ID | O96020-2 |
| Features which should be applied to build the isoform sequence: VSP_001256. |
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- TISSUE SPECIFICITY: According to Ref.1: highest levels in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed proliferating cells. According to Ref.2: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to Ref.3: highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon.
- INDUCTION: Activated by papilloma viral oncoproteins E6 and E7 which bind to and inactivate p53 and Rb, respectively.
- PTM: Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway (By similarity).
- SIMILARITY: Belongs to the cyclin family. Cyclin E subfamily.
- WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ccne2/";.
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