ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry O95749


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name GGPPS_HUMAN
Primary accession number O95749
Secondary accession numbers Q5T2C8 Q6NW19
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on May 1, 1999 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 82)
Name and origin of the protein
Protein name Geranylgeranyl pyrophosphate synthetase
Synonyms GGPP synthetase
GGPPSase
Geranylgeranyl diphosphate synthase
Includes Dimethylallyltranstransferase
     (EC 2.5.1.1)
Geranyltranstransferase
     (EC 2.5.1.10)
Farnesyltranstransferase
     (EC 2.5.1.29)
Gene name
Name: GGPS1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Fetal heart;
PubMed=9741684 [NCBI, ExPASy, EBI, Israel, Japan]
Ericsson J., Greene J.M., Carter K.C., Shell B.K., Duan D.R., Florence C., Edwards P.A.;
"Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression.";
J. Lipid Res. 39:1731-1739(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Testis;
DOI=10.1074/jbc.274.9.5888; PubMed=10026212 [NCBI, ExPASy, EBI, Israel, Japan]
Kuzuguchi T., Morita Y., Sagami I., Sagami H., Ogura K.;
"Human geranylgeranyl diphosphate synthase. cDNA cloning and expression.";
J. Biol. Chem. 274:5888-5894(1999).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
Misawa N., Okazaki H., Noguchi Y., Tatsuno I., Saito Y., Yasuda T., Hirai A.;
"Study on isolation of a geranylgeranyl pyrophosphate (GGPP) synthase cDNA and its expression -- development of a new assay system of gene functions.";
Proc. Jpn. Conf. Biochem. Lipids 41:293-296(1999).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Pituitary;
DOI=10.1073/pnas.160270997; PubMed=10931946 [NCBI, ExPASy, EBI, Israel, Japan]
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.;
"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.";
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
[5]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver, and Spleen;
DOI=10.1016/S1388-1981(99)00028-1; PubMed=10101267 [NCBI, ExPASy, EBI, Israel, Japan]
Kainou T., Kawamura K., Tanaka K., Matsuda H., Kawamukai M.;
"Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and human.";
Biochim. Biophys. Acta 1437:333-340(1999).
[6]
NUCLEOTIDE SEQUENCE [MRNA].
Zhang M., Yu L., Hu P., Bi A., Zhang Q., Xu M., Zhao S.;
"Molecular cloning and expression analysis of a novel human cDNA encoding a protein homologous to Neurospora crassa geranylgeranyl pyrophosphate synthetase.";
Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney, and Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB017971; BAA75909.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB019036; BAA77251.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF125394; AAD43050.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB016043; BAA76511.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF057698; AAG45581.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL391994; CAI13753.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC005252; AAH05252.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC067768; AAH67768.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001032354.1; -.
NP_001032355.1; -.
NP_004828.1; -.
UniGene Hs.647791
3D structure databases
PDB
2Q80; X-ray; 2.70 A; A/B/C/D/E/F=1-300.[ExPASy / RCSB / EBI]
PDBsum 2Q80; -.
ModBase O95749.
PTM databases
PhosphoSite O95749; -.
Enzyme and pathway databases
Reactome REACT_602; Lipid and lipoprotein metabolism.
Organism-specific databases
GeneCards GC01P233558; -.
H-InvDB HIX0001713; -.
HGNC HGNC:4249; GGPS1.
GenAtlas GGPS1.
MIM 606982; gene. [NCBI / EBI]
PharmGKB PA28661; -.
GeneCards O95749.
Gene expression databases
ArrayExpress O95749; -.
CleanEx HS_GGPS1; -.
GermOnline ENSG00000152904; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0005625; Cellular component: soluble fraction (inferred from direct assay from UniProtKB).
GO:0004161; Molecular function: dimethylallyltranstransferase activity (inferred from electronic annotation from EC).
GO:0004311; Molecular function: farnesyltranstransferase activity (inferred from direct assay from UniProtKB).
GO:0004337; Molecular function: geranyltranstransferase activity (inferred from electronic annotation from EC).
GO:0008299; Biological process: isoprenoid biosynthetic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR000092; Polyprenyl_synt.
IPR017446; Polyprenyl_synth-rel.
IPR008949; Terpenoid_synth.
Graphical view of domain structure.
Gene3D G3DSA:1.10.600.10; Terpenoid_synth; 1.
PANTHER PTHR12001; Polyprenyl_synt; 1.
Pfam PF00348; polyprenyl_synt; 1.
Pfam graphical view of domain structure.
PROSITE PS00723; POLYPRENYL_SYNTHET_1; 1.
PS00444; POLYPRENYL_SYNTHET_2; 1.
Proteomics databases
PRIDE O95749; -.
Genome annotation databases
Ensembl ENSG00000152904; Homo sapiens. [Contig view]
GeneID 9453; -.
KEGG hsa:9453; -.
Phylogenomic databases
HOGENOM O95749; -.
HOVERGEN O95749; -.
Other
NextBio 35412; -.
SOURCE GGPS1; Homo sapiens.
ProtoNet O95749.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Cytoplasm; Isoprene biosynthesis; Multifunctional enzyme; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   300  300     Geranylgeranyl pyrophosphate synthetase. PRO_0000123962
CONFLICT   109   109        P -> Q (in Ref. 8; AAH67768). 
HELIX   9    13  5      
HELIX   15    20  6      
HELIX   26    40  15      
HELIX   44    69  26      
STRAND   72    74  3      
HELIX   80    84  5      
HELIX   86   105  20      
HELIX   112   135  24      
HELIX   142   166  25      
HELIX   175   195  21      
HELIX   207   211  5      
HELIX   216   224  9      
HELIX   230   236  7      
HELIX   242   254  13      
HELIX   257   278  22      
HELIX   283   293  11      
Sequence information
Length: 300 AA [This is the length of the unprocessed precursor] Molecular weight: 34871 Da [This is the MW of the unprocessed precursor] CRC64: F5D1959274BEE27A [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEKTQETVQR ILLEPYKYLL QLPGKQVRTK LSQAFNHWLK VPEDKLQIII EVTEMLHNAS 

        70         80         90        100        110        120 
LLIDDIEDNS KLRRGFPVAH SIYGIPSVIN SANYVYFLGL EKVLTLDHPD AVKLFTRQLL 

       130        140        150        160        170        180 
ELHQGQGLDI YWRDNYTCPT EEEYKAMVLQ KTGGLFGLAV GLMQLFSDYK EDLKPLLNTL 

       190        200        210        220        230        240 
GLFFQIRDDY ANLHSKEYSE NKSFCEDLTE GKFSFPTIHA IWSRPESTQV QNILRQRTEN 

       250        260        270        280        290        300 
IDIKKYCVHY LEDVGSFEYT RNTLKELEAK AYKQIDARGG NPELVALVKH LSKMFKEENE 

O95749 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by kr flag YPRC Korea Mirror sites: Australia  Brazil  Canada  China  Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!