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UniProtKB/Swiss-Prot entry O94069

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HEM1_CANAL
Primary accession number O94069
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on May 1, 1999 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 57)
Name and origin of the protein
Protein name 5-aminolevulinate synthase, mitochondrial [Precursor]
Synonyms EC 2.3.1.37
5-aminolevulinic acid synthase
Delta-aminolevulinate synthase
Delta-ALA synthetase
Gene name
Name: HEM1
ORFNames: Ca49C4.15
From
Candida albicans (Yeast) [TaxID: 5476] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; mitosporic Saccharomycetales; Candida.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=1161;
Murphy L., Harris D., Barrell B.G., Rajandream M.A.;
"Candida albicans strain 1161 genome pilot sequencing project.";
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AL033503; CAA22025.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T18251; T18251.
3D structure databases
HSSP P07912; 1FC4. [HSSP ENTRY / PDB]
ModBase O94069.
Organism-specific databases
CGD CAL0003351; HEM1.
Ontologies
GO
GO:0005759; Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
GO:0003870; Molecular function: 5-aminolevulinate synthase activity (inferred from electronic annotation from InterPro).
GO:0030170; Molecular function: pyridoxal phosphate binding (inferred from electronic annotation from InterPro).
GO:0016769; Molecular function: transferase activity, transferring nitrogenous groups (inferred from electronic annotation from InterPro).
GO:0006783; Biological process: heme biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR010961; 4pyrrol_synth_NH2levulA_synth.
IPR004839; Aminotrans_I/II.
IPR001917; Aminotrans_II_pyridoxalP_BS.
IPR015421; PyrdxlP-dep_Trfase_major_sub1.
Graphical view of domain structure.
Gene3D G3DSA:3.40.640.10; PyrdxlP-dep_Trfase_major_sub1; 1.
Pfam PF00155; Aminotran_1_2; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01821; 5aminolev_synth; 1.
PROSITE PS00599; AA_TRANSFER_CLASS_2; 1.
Other
ProtoNet O94069.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acyltransferase; Heme biosynthesis; Mitochondrion; Pyridoxal phosphate; Transferase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1     ?        Mitochondrion. 
CHAIN   ?   564        5-aminolevulinate synthase, mitochondrial. PRO_0000001237
BINDING   353   353        Pyridoxal phosphate (covalent) (Probable). 
Sequence information
Length: 564 AA [This is the length of the unprocessed precursor] Molecular weight: 61395 Da [This is the MW of the unprocessed precursor] CRC64: C984334068F40487 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MESITKVSMS VCPFVRSTST QALRQLSQTS GALANQARQC PIAGNAIRAK EISIRSYSSA 

        70         80         90        100        110        120 
TKPVRATAAT PSTPEATFNV SSSFELGSKE TAFDYNGYLG NELEKKRSDK SYRYFNNINR 

       130        140        150        160        170        180 
LANEFPKAHR TQEEDKVTVW CSNDYLGMGK NENTLKEMKR VLDKYGSGAG GTRNIAGHNS 

       190        200        210        220        230        240 
HAIKLESELA ALHKHDAALV FSSCFVANDA VLSLLGQKIK DLVIFSDELN HASMIQGIRN 

       250        260        270        280        290        300 
SRARKHIFKH NNLADLESKL AQYPKSTPKL IAFESVYSMC GSIAPIEAIC DLAEKYGALT 

       310        320        330        340        350        360 
FLDEVHAVGM YGPHGAGVAE HLNFEAHLKS GIERPEITTV MSRVDMVTGT LGKAYGVVGG 

       370        380        390        400        410        420 
YITGKTNLID WFRSYAPGFI FTTSLPPAIM AGCSASIRYQ RATLKDRIAQ QKNTRLVKNN 

       430        440        450        460        470        480 
LNELGIPVIP NPSHIVPVLV GNAADAKRAS DLLLNKHDIY VQAINFPTVP IGEERLRITP 

       490        500        510        520        530        540 
TPGHGPELSK QLVEAVDSVF TELNLNRIND WKKLGGLVGV GVEGAAKVEH IWTEEQLALT 

       550        560 
DADLNPNVVN PAISPLDVSS GIST
O94069 in FASTA format

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