NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1007/s002030050716; PubMed=10382262 [NCBI, ExPASy, EBI, Israel, Japan]
Shima S., Netrusov A., Sordel M., Wicke M., Hartmann G.C., Thauer R.K.;
"Purification, characterization, and primary structure of a monofunctional catalase from Methanosarcina barkeri.";
Arch. Microbiol. 171:317-323(1999).

[2]

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1128/JB.00810-06; PubMed=16980466 [NCBI, ExPASy, EBI, Israel, Japan]
Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S., Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R.;
"The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes.";
J. Bacteriol. 188:7922-7931(2006).

Comments

FUNCTION: Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
CATALYTIC ACTIVITY: 2 H₂O₂ = O₂ + 2 H₂O.
COFACTOR: Heme group (By similarity).
SIMILARITY: Belongs to the catalase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AJ005939; CAA06774.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
CP000099; AAZ69791.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_304371.1; -.

3D structure databases

HSSP

P04040; 1F4J. [HSSP ENTRY / PDB]

ModBase

O93662.

Enzyme and pathway databases

BioCyc

MBAR269797:MBAR_A0814-MON; -.

Ontologies

GO:0004096;	Molecular function: catalase activity (inferred from electronic annotation from InterPro).
GO:0005506;	Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0042744;	Biological process: hydrogen peroxide catabolic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR002226; Catalase.
IPR011614; Catalase_N.
Graphical view of domain structure.

Gene3D

G3DSA:2.40.180.10; Catalase_N; 1.

PANTHER

PTHR11465; Catalase; 1.

Pfam

PF00199; Catalase; 1.
Pfam graphical view of domain structure.

PRINTS

PR00067; CATALASE.

ProDom

PD000510; Catalase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS00437; CATALASE_1; 1.
PS00438; CATALASE_2; 1.
PS51402; CATALASE_3; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

GeneID

3626836; -.

GenomeReviews

CP000099_GR; Mbar_A0814.

KEGG

mba:Mbar_A0814; -.

NMPDR

fig|269797.3.peg.254; -.

Phylogenomic databases

HOGENOM

O93662; -.

Genome annotation databases

CMR

O93662; Mbar_A0814.

Other

ProtoNet

O93662.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Heme; Hydrogen peroxide; Iron; Metal-binding; Oxidoreductase; Peroxidase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 505`	`505`	`Catalase.`	`PRO_0000085019`
`ACT_SITE`	`58 58`		`By similarity.`
`ACT_SITE`	`131 131`		`By similarity.`
`METAL`	`341 341`		`Iron (heme axial ligand) (By similarity).`

Sequence information

Length: 505 AA [This is the length of the unprocessed precursor]

Molecular weight: 57066 Da [This is the MW of the unprocessed precursor]

CRC64: 2A27C4BEC47BE854 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGEKNSSKVL TTGFGIPVGD DQNSLTAGNR GPVLMQDVHL LDKLSHFDHE RIPERVVHAK 

        70         80         90        100        110        120 
GAGAGGYFEV TADVTKYTKA KFLSEIGKRT EVFVRFSTVG GEKGSADSAR DPRGFAVKFY 

       130        140        150        160        170        180 
TEDGNYDLVG NNTPVFFIRD PLKFPDFIHT QKRNPATNCK DPDMFWDFLS LTPESIHQVT 

       190        200        210        220        230        240 
ILFSDRGTPA TYRNMNGYSS HTYKWYNEKG EYFWVQYHFK TDQGIKNLTL EEAEKIGGSD 

       250        260        270        280        290        300 
PDHATRDLYE AIKKGDYPSW TLEMQIMTPE QAEDYRFDIR DITKVWPHGD FPTMKIGKLV 

       310        320        330        340        350        360 
LNRNPTNYFA EVEQAAFSPA NLVPGIGISP DKMLQGRVFS YHDTHIHRLG PNYNLIPVNA 

       370        380        390        400        410        420 
PKYSPENSYQ RDGFMRVDAN GGSGPNYWPN SFGGPSPDSV YLEPPFGVSG LAARTLYTHP 

       430        440        450        460        470        480 
NDDFVQAGNL YRDVMTDYDR ENLVGNIVSH LSAAQKRIQL RQTALFFKAD RDYGSRVAKG 

       490        500 
LELDIKEVER LANMTNEERA RATER

O93662 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools