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UniProtKB/Swiss-Prot entry O93541

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDHA_CHAGU
Primary accession number O93541
Secondary accession numbers None
Integrated into Swiss-Prot on December 5, 2001
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 55)
Name and origin of the protein
Protein name L-lactate dehydrogenase A chain
Synonyms LDH-A
EC 1.1.1.27
Gene name
Name: ldha
From
Champsocephalus gunnari (Mackerel icefish) [TaxID: 52237] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; Acanthomorpha; Acanthopterygii; Percomorpha; Perciformes; Notothenioidei; Channichthyidae; Champsocephalus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Muscle;
DOI=10.1073/pnas.95.19.11476; PubMed=9736762 [NCBI, ExPASy, EBI, Israel, Japan]
Fields P.A., Somero G.N.;
"Hot spots in cold adaptation: localized increases in conformational flexibility in lactate dehydrogenase A4 orthologs of Antarctic notothenioid fishes.";
Proc. Natl. Acad. Sci. U.S.A. 95:11476-11481(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF079824; AAC63282.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
PDB
2V65; X-ray; 2.35 A; A/B=1-331.[ExPASy / RCSB / EBI]
PDBsum 2V65; -.
ModBase O93541.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0004459; Molecular function: L-lactate dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0019642; Biological process: anaerobic glycolysis (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
Phylogenomic databases
HOVERGEN O93541; -.
Other
ProtoNet O93541.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Cytoplasm; Glycolysis; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   331  330     L-lactate dehydrogenase A chain. PRO_0000168431
NP_BIND   29    57  29     NAD (By similarity). 
ACT_SITE   192   192        Proton acceptor (By similarity). 
BINDING   98    98        NAD (By similarity). 
BINDING   105   105        Substrate (By similarity). 
BINDING   137   137        NAD or substrate (By similarity). 
BINDING   168   168        Substrate (By similarity). 
BINDING   247   247        Substrate (By similarity). 
STRAND   3    14  12      
STRAND   17    21  5      
STRAND   24    87  64      
STRAND   89    96  8      
STRAND   103   126  24      
STRAND   131   151  21      
STRAND   154   179  26      
STRAND   181   196  16      
STRAND   199   208  10      
STRAND   215   269  55      
STRAND   272   289  18      
STRAND   292   330  39      
Sequence information
Length: 331 AA [This is the length of the unprocessed precursor] Molecular weight: 36156 Da [This is the MW of the unprocessed precursor] CRC64: 556546DC3A03237E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSTKEKLISH VMKEEPVGSR SKVTVVGVGM VGMASAISIL LKDLCDELAM VDVMEDKLKG 

        70         80         90        100        110        120 
EVMDLQHGSL FLKTKIVGDK DYSVTANSKV VVVTAGARQQ EGESRLNLVQ RNVNIFKFII 

       130        140        150        160        170        180 
PNIVKYSPNC ILMVVSNPVD ILTYVAWKLS GFPRHRVIGS GTNLDSARFR HLIGEKLHLH 

       190        200        210        220        230        240 
PSSCHAWIVG EHGDSSVPVW SGVNVAGVSL QGLNPQMGTE GDGENWKAIH KEVVDGAYEV 

       250        260        270        280        290        300 
IKLKGYTSWA IGMSVADLVE SIIKNMHKVH PVSTLVQGMH GVKDEVFLSV PCVLGNSGLT 

       310        320        330 
DVIHMTLKAE EEKQLQKSAE TLWGVQKELT L
O93541 in FASTA format

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