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[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND EXPRESSION.
STRAIN=ATCC 23641;
PubMed=9696760 [NCBI, ExPASy, EBI, Israel, Japan]
Baker S.H.,
Jin S.,
Aldrich H.C.,
Howard G.T.,
Shively J.M.;
"Insertion mutation of the form I cbbL gene encoding ribulose bisphosphate carboxylase/oxygenase (RuBisCO) in Thiobacillus neapolitanus results in expression of form II RuBisCO, loss of carboxysomes, and an increased CO2 requirement for growth.";
J. Bacteriol. 180:4133-4139(1998).
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[2]
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X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).
Kerfeld C.A.,
Sawaya M.R.,
Pashkov I.,
Cannon G.,
Williams E.,
Tran K.,
Yeates T.O.;
"The structure of Halothiobacillus neapolitanus Rubisco.";
Submitted (APR-2005) to the PDB data bank.
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- FUNCTION: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site (By similarity).
- CATALYTIC ACTIVITY: 2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.
- CATALYTIC ACTIVITY: 3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.
- COFACTOR: Binds 1 magnesium ion per subunit (By similarity).
- SUBUNIT: Heterohexadecamer of 8 large chains and 8 small chains (By similarity).
- INDUCTION: Produced when grown in air or in air supplemented with 5% CO(2).
- MISCELLANEOUS: The basic functional RuBisCO is composed of a large chain homodimer in a "head-to-tail" conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric "cap" on each end of the "barrel" (By similarity).
- SIMILARITY: Belongs to the RuBisCO large chain family. Type I subfamily.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 473 AA [This is the length of the unprocessed precursor] |
Molecular weight: 52636 Da [This is the MW of the unprocessed precursor] |
CRC64: B84D2EDE46CAF7D8 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MAVKKYSAGV KEYRQTYWMP EYTPLDSDIL ACFKITPQPG VDREEAAAAV AAESSTGTWT
70 80 90 100 110 120
TVWTDLLTDM DYYKGRAYRI EDVPGDDAAF YAFIAYPIDL FEEGSVVNVF TSLVGNVFGF
130 140 150 160 170 180
KAVRGLRLED VRFPLAYVKT CGGPPHGIQV ERDKMNKYGR PLLGCTIKPK LGLSAKNYGR
190 200 210 220 230 240
AVYECLRGGL DFTKDDENIN SQPFMRWRDR FLFVQDATET AEAQTGERKG HYLNVTAPTP
250 260 270 280 290 300
EEMYKRAEFA KEIGAPIIMH DYITGGFTAN TGLAKWCQDN GVLLHIHRAM HAVIDRNPNH
310 320 330 340 350 360
GIHFRVLTKI LRLSGGDHLH TGTVVGKLEG DRASTLGWID LLRESFIPED RSRGIFFDQD
370 380 390 400 410 420
WGSMPGVFAV ASGGIHVWHM PALVNIFGDD SVLQFGGGTL GHPWGNAAGA AANRVALEAC
430 440 450 460 470
VEARNQGRDI EKEGKEILTA AAQHSPELKI AMETWKEIKF EFDTVDKLDT QNR
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O85040 in FASTA format |
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