ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry O84969


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name NUOA_RHOCA
Primary accession number O84969
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on November 1, 1998 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 39)
Name and origin of the protein
Protein name NADH-quinone oxidoreductase subunit A
Synonyms EC 1.6.99.5
NADH dehydrogenase I subunit A
NDH-1 subunit A
Gene name
Name: nuoA
From
Rhodobacter capsulatus (Rhodopseudomonas capsulata) [TaxID: 1061] 
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales; Rhodobacteraceae; Rhodobacter.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 33303 / B10;
Dupuis A., Issartel J.P.;
Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
Comments
  • FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
  • CATALYTIC ACTIVITY: NADH + quinone = NAD+ + quinol.
  • SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
  • SIMILARITY: Belongs to the complex I subunit 3 family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF029365; AAC24985.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
ModBase O84969.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0008137; Molecular function: NADH dehydrogenase (ubiquinone) activity (inferred from electronic annotation from InterPro).
GO:0048038; Molecular function: quinone binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006120; Biological process: mitochondrial electron transport, NADH to ubiquinone (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR000440; Oxidored_q4.
Graphical view of domain structure.
PANTHER PTHR11058; Oxidored_q4; 1.
Pfam PF00507; Oxidored_q4; 1.
Pfam graphical view of domain structure.
Other
ProtoNet O84969.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell membrane; Membrane; NAD; Oxidoreductase; Quinone; Transmembrane; Ubiquinone.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom  To Length Description FTId
CHAIN   1   126  126     NADH-quinone oxidoreductase subunit A. PRO_0000117874
TRANSMEM   17    37  21     Potential. 
TRANSMEM   73    93  21     Potential. 
TRANSMEM   95   115  21     Potential. 
Sequence information
Length: 126 AA [This is the length of the unprocessed precursor] Molecular weight: 14236 Da [This is the MW of the unprocessed precursor] CRC64: 886F96018688C876 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MQDALTHGML REYLPILVLL AMAIGLGLIL IAAAAIIAYR NPDPEKVSAY ECGFNAFDDA 

        70         80         90        100        110        120 
RMKFDVRFYL VSILFIIFDL EVAFLFPWAV AFGDMSMTAF WSMMVFLSVL TVGFAYEWKK 


GALEWA 

O84969 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by kr flag YPRC Korea Mirror sites: Australia  Brazil  Canada  China  Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!