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UniProtKB/Swiss-Prot entry O83401

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MURF_TREPA
Primary accession number O83401
Secondary accession numbers None
Integrated into Swiss-Prot on December 15, 1998
Sequence was last modified on November 1, 1998 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 62)
Name and origin of the protein
Protein name UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
Synonyms EC 6.3.2.10
UDP-MurNAc-pentapeptide synthetase
D-alanyl-D-alanine-adding enzyme
Gene name
Name: murF
OrderedLocusNames: TP_0386
From
Treponema pallidum [TaxID: 160] [HAMAP proteome]
Taxonomy Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Treponema.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Nichols;
DOI=10.1126/science.281.5375.375; PubMed=9665876 [NCBI, ExPASy, EBI, Israel, Japan]
Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D., Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O., Venter J.C.;
"Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
Science 281:375-388(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000520; AAC65370.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR D71331; D71331.
RefSeq NP_218826.1; -.
3D structure databases
HSSP P11880; 1GG4. [HSSP ENTRY / PDB]
ModBase O83401.
Protein-protein interaction databases
IntAct O83401; 1.
Enzyme and pathway databases
BioCyc TPAL243276:TP_0386-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0047480; Molecular function: UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity (inferred from electronic annotation from EC).
GO:0008766; Molecular function: UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity (inferred from electronic annotation from InterPro).
GO:0007049; Biological process: cell cycle (inferred from electronic annotation from UniProtKB-KW).
GO:0051301; Biological process: cell division (inferred from electronic annotation from InterPro).
GO:0009252; Biological process: peptidoglycan biosynthetic process (inferred from electronic annotation from InterPro).
GO:0008360; Biological process: regulation of cell shape (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR004101; Mur_ligase_C.
IPR013221; Mur_ligase_cen.
IPR000713; Mur_ligase_N.
IPR005863; UDP-N-AcMur-3pep_AlaAla_ligase.
Graphical view of domain structure.
Gene3D G3DSA:3.90.190.20; Mur_ligase_C; 1.
G3DSA:3.40.1190.10; Mur_ligase_cen; 1.
PANTHER PTHR23135:SF3; MurF; 1.
Pfam PF01225; Mur_ligase; 1.
PF02875; Mur_ligase_C; 1.
PF08245; Mur_ligase_M; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01143; murF; 1.
Genome annotation databases
GeneID 2611288; -.
GenomeReviews AE000520_GR; TP_0386.
KEGG tpa:TP0386; -.
NMPDR fig|243276.1.peg.385; -.
TIGR TP_0386; -.
Phylogenomic databases
HOGENOM O83401; -.
Other
ProtoNet O83401.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Cell cycle; Cell division; Cell shape; Cell wall biogenesis/degradation; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding; Peptidoglycan synthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   459  459     UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase. PRO_0000101707
NP_BIND   121   127  7     ATP (Potential). 
Sequence information
Length: 459 AA [This is the length of the unprocessed precursor] Molecular weight: 50235 Da [This is the MW of the unprocessed precursor] CRC64: 23EA5571ED95F332 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLLSFDEVCA AVQGARVCDA RGARGFDGVS FDSRAVVPRD LFIPLRGAHV DGHTFVEEAL 

        70         80         90        100        110        120 
QKGAVATLID QRYPHAGEYV AWCTRFGAAC IAVHDTLRAL QDLASFYCKK FPALIRIGIT 

       130        140        150        160        170        180 
GSSGKTTVKE MARAVFSERY RVVATPGNLN SEIGLPQSLF FVRAEHEVGI FELGMNRRGE 

       190        200        210        220        230        240 
MRTLAQILVP HYAIITNVGC AHVGILGTQQ AIAEEKKEIF SQFTEHSVGF VPDDAYRVFL 

       250        260        270        280        290        300 
SNIPYGRVVV YDQGGRGLAT EVIDEGLRGS RVLYQGRWIR VPLPGVHNAK NALAVIALAA 

       310        320        330        340        350        360 
QVGLPAEEIQ RGMERVKPPF GRSHVVCASL TFLLDCYNAN PDSMAAALHL CAHISAVSKV 

       370        380        390        400        410        420 
YVLGDMGELG VTAAEAHYRV CVLAAASDAR AVYVFGPEFC RAVRKVSWGR KRVYAFALEE 

       430        440        450 
LSALQETLDA QLRRGDFVLV KGSRSVALER LEPLLRKER
O83401 in FASTA format

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