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UniProtKB/Swiss-Prot entry O77588

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PLOD1_BOVIN
Primary accession number O77588
Secondary accession number Q1JPK0
Integrated into Swiss-Prot on December 15, 1998
Sequence was last modified on July 25, 2006 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 59)
Name and origin of the protein
Protein name Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 [Precursor]
Synonyms EC 1.14.11.4
Lysyl hydroxylase 1
LH1
Gene name
Name: PLOD1
Synonyms: PLOD
From
Bos taurus (Bovine) [TaxID: 9913] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
Knight M.A., Drinkwater R.D.;
Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1186/1471-2164-6-166; PubMed=16305752 [NCBI, ExPASy, EBI, Israel, Japan]
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
"Characterization of 954 bovine full-CDS cDNA sequences.";
BMC Genomics 6:166-166(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF054274; AAC25107.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT025353; ABF57309.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_776573.1; -.
UniGene Bt.4998
3D structure databases
ModBase O77588.
Ontologies
GO
GO:0030867; Cellular component: rough endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from InterPro).
GO:0031418; Molecular function: L-ascorbic acid binding (inferred from electronic annotation from UniProtKB-KW).
GO:0016702; Molecular function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (inferred from electronic annotation from UniProtKB-KW).
GO:0008475; Molecular function: procollagen-lysine 5-dioxygenase activity (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0019538; Biological process: protein metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR005123; 2OG-FeII_Oase.
IPR006620; Pro_4_hyd_alph.
IPR001006; Procol_lys_dOase.
Graphical view of domain structure.
Pfam PF03171; 2OG-FeII_Oxy; 1.
Pfam graphical view of domain structure.
ProDom PD011578; ProcolLys_dioxy; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00702; P4Hc; 1.
SMART graphical view of domain structure.
PROSITE PS01325; LYS_HYDROXYLASE; 1.
Genome annotation databases
Ensembl ENSBTAG00000002052; Bos taurus. [Contig view]
GeneID 281409; -.
KEGG bta:281409; -.
Phylogenomic databases
HOVERGEN O77588; -.
Other
ProtoNet O77588.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Dioxygenase; Endoplasmic reticulum; Glycoprotein; Iron; Membrane; Metal-binding; Oxidoreductase; Signal; Vitamin C.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    18  18     By similarity. 
CHAIN   19   726  708     Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1. PRO_0000024677
DOMAIN   552   726  175     PKHD. 
ACT_SITE   717   717        Potential. 
METAL   655   655        Iron (By similarity). 
METAL   657   657        Iron (By similarity). 
METAL   707   707        Iron (By similarity). 
CARBOHYD   196   196        N-linked (GlcNAc...) (Potential). 
CARBOHYD   537   537        N-linked (GlcNAc...) (Potential). 
CARBOHYD   685   685        N-linked (GlcNAc...) (Potential). 
CONFLICT   140   140        K -> N (in Ref. 1; AAC25107). 
CONFLICT   164   164        S -> I (in Ref. 1; AAC25107). 
CONFLICT   209   210        LD -> FH (in Ref. 1; AAC25107). 
CONFLICT   309   309        R -> L (in Ref. 1; AAC25107). 
CONFLICT   317   317        L -> F (in Ref. 1; AAC25107). 
CONFLICT   404   404        A -> T (in Ref. 1; AAC25107). 
CONFLICT   607   607        F -> Y (in Ref. 1; AAC25107). 
CONFLICT   666   666        A -> G (in Ref. 1; AAC25107). 
CONFLICT   710   710        L -> V (in Ref. 1; AAC25107). 
Sequence information
Length: 726 AA [This is the length of the unprocessed precursor] Molecular weight: 83487 Da [This is the MW of the unprocessed precursor] CRC64: D215F7E093CCADE9 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRLLLLLAPL GWLLLAETKG DAKPEDNLLV LTVATKETEG FRRFKRSAQF FNYKIQALGL 

        70         80         90        100        110        120 
GEDWPGEAML AGGGLKVRLL KKALEKHADK ENLVILFTDS YDVVFASGPR ELLKKFRQAR 

       130        140        150        160        170        180 
SQVVFSAEEL IYPDRRLEAK YPVVSDGKRF LGSGGFIGYA PNLSKLVAEW EGQDSDSDQL 

       190        200        210        220        230        240 
FYTKIFLDPE KREQINITLD HRCRIFQNLD GALDEVVLKF EMGQVRARNL AYDTLPVLIH 

       250        260        270        280        290        300 
GNGPTKLQLN YLGNYIPRFW TFETGCAVCD EGLRSLKGIG DEALPAVLVG VFIEQPTPFL 

       310        320        330        340        350        360 
SLFFQRLLRL HYPQKRLRLF IHNHEQHHKA QVEQFLAEHG DEYQSVKLVG PEVRVANADA 

       370        380        390        400        410        420 
RNMGADLCRQ DRGCTYYFSV DADVALTEPK TLRLLIEQNK NVIAPLMTRH GRLWSNFWGA 

       430        440        450        460        470        480 
LSADGYYARS EDYVDIVQGR RVGVWNVPYI SNIYLIKGSA LRAELQETDL FHHSKLDPDM 

       490        500        510        520        530        540 
AFCANIRQQD VFMFLTNRHS FGHLLSLDSY QTTHLHNDLW EVFSNPEDWK EKYIHENYTK 

       550        560        570        580        590        600 
ALAGKMVEMP CPDVYWFPIF TETACDELVE EMEHYGQWSL GDNKDNRIQG GYENVPTIDI 

       610        620        630        640        650        660 
HMNQINFERE WHKFLVEYIA PMTEKLYPGY YTRAQFDLAF VVRYKPDEQP SLVPHHDAST 

       670        680        690        700        710        720 
FTINIALNRV GVDYEGGGCR FLRYNCSIRA PRKGWTLMHP GRLTHYHEGL PTTKGTRYIA 


VSFVDP
O77588 in FASTA format

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