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[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), AND VARIANT ILE-299.
DOI=10.1006/geno.1998.5296; PubMed=9615229 [NCBI, ExPASy, EBI, Israel, Japan]
Lemmens I.H.,
Kas K.,
Merregaert J.,
Van de Ven W.J.M.;
"Identification and molecular characterization of TM7SF2 in the FAUNA gene cluster on human chromosome 11q13.";
Genomics 49:437-442(1998).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), VARIANT ILE-299, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
DOI=10.1006/geno.1998.5615; PubMed=9878250 [NCBI, ExPASy, EBI, Israel, Japan]
Holmer L.,
Pezhman A.,
Worman H.J.;
"The human lamin B receptor/sterol reductase multigene family.";
Genomics 54:469-476(1998).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT ILE-299.
TISSUE=Brain, Eye, and Ovary;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[4]
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FUNCTION.
PubMed=11784322 [NCBI, ExPASy, EBI, Israel, Japan]
Roberti R.,
Bennati A.M.,
Galli G.,
Caruso D.,
Maras B.,
Aisa C.,
Beccari T.,
Della Fazia M.A.,
Servillo G.;
"Cloning and expression of sterol Delta14-reductase from bovine liver.";
Eur. J. Biochem. 269:283-290(2002).
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- FUNCTION: Involved in the conversion of lanosterol to cholesterol.
- CATALYTIC ACTIVITY: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NADP+ = 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol + NADPH.
- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.
- ALTERNATIVE PRODUCTS:
2 named isoforms [FASTA] produced by alternative splicing.
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| Name | 2 |
| Isoform ID | O76062-2 |
| Note: No experimental confirmation available. |
| Features which should be applied to build the isoform sequence: VSP_017898. |
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- TISSUE SPECIFICITY: Expressed in adult heart, brain, pancreas, lung, liver, skeletal muscle, kidney, ovary, prostate, and testis, but not detected in placenta, spleen, thymus, small intestine, colon (mucosal lining), or peripheral blood leukocytes.
- SIMILARITY: Belongs to the ERG4/ERG24 family.
- SEQUENCE CAUTION:
- Sequence=AAC21450.1; Type=Miscellaneous discrepancy; Note=Sequencing errors
- Sequence=AAC21457.1; Type=Miscellaneous discrepancy; Note=Sequencing errors
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 418 AA [This is the length of the unprocessed precursor] |
Molecular weight: 46406 Da [This is the MW of the unprocessed precursor] |
CRC64: F5618ABE2BF0A911 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MAPTQGPRAP LEFGGPLGAA ALLLLLPATM FHLLLAARSG PARLLGPPAS LPGLEVLWSP
70 80 90 100 110 120
RALLLWLAWL GLQAALYLLP ARKVAEGQEL KDKSRLRYPI NGFQALVLTA LLVGLGMSAG
130 140 150 160 170 180
LPLGALPEML LPLAFVATLT AFIFSLFLYM KAQVAPVSAL APGGNSGNPI YDFFLGRELN
190 200 210 220 230 240
PRICFFDFKY FCELRPGLIG WVLINLALLM KEAELRGSPS LAMWLVNGFQ LLYVGDALWH
250 260 270 280 290 300
EEAVLTTMDI THDGFGFMLA FGDMAWVPFT YSLQAQFLLH HPQPLGLPMA SVICLINATG
310 320 330 340 350 360
YYIFRGANSQ KNTFRKNPSD PRVAGLETIS TATGRKLLVS GWWGMVRHPN YLGDLIMALA
370 380 390 400 410
WSLPCGVSHL LPYFYLLYFT ALLVHREARD ERQCLQKYGL AWQEYCRRVP YRIMPYIY
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O76062 in FASTA format |
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