ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry O74298

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name LYS2_PENCH
Primary accession number O74298
Secondary accession numbers None
Integrated into Swiss-Prot on September 27, 2004
Sequence was last modified on November 1, 1998 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 44)
Name and origin of the protein
Protein name L-aminoadipate-semialdehyde dehydrogenase large subunit
Synonyms EC 1.2.1.31
Alpha-aminoadipate reductase
Alpha-AR
Gene name
Name: lys2
From
Penicillium chrysogenum (Penicillium notatum) [TaxID: 5076] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; Eurotiomycetidae; Eurotiales; Trichocomaceae; mitosporic Trichocomaceae; Penicillium; Penicillium chrysogenum complex.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=AS-P-78;
DOI=10.1007/s004380050847; PubMed=9790587 [NCBI, ExPASy, EBI, Israel, Japan]
Casqueiro J., Gutierrez S., Banuelos O., Fierro F., Velasco J., Martin J.F.;
"Characterization of the lys2 gene of Penicillium chrysogenum encoding alpha-aminoadipic acid reductase.";
Mol. Gen. Genet. 259:549-556(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Y13967; CAA74300.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P14687; 1AMU. [HSSP ENTRY / PDB]
ModBase O74298.
Ontologies
GO
GO:0000036; Molecular function: acyl carrier activity (inferred from electronic annotation from InterPro).
GO:0048037; Molecular function: cofactor binding (inferred from electronic annotation from InterPro).
GO:0004043; Molecular function: L-aminoadipate-semialdehyde dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0016874; Molecular function: ligase activity (inferred from electronic annotation from InterPro).
GO:0031177; Molecular function: phosphopantetheine binding (inferred from electronic annotation from InterPro).
GO:0009085; Biological process: lysine biosynthetic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR010071; AA_adenyl_dom.
IPR009081; ACP_like.
IPR000873; AMP-dep_Synth/Lig.
IPR014397; L-NH2adipate-semiAld_DH_lsu.
IPR013120; Male_sterile_NAD-bd.
IPR016040; NAD(P)-bd.
IPR006163; Phsphopanteth_bd.
IPR006162; Ppantne_S.
IPR010080; Thioester_reductase.
Graphical view of domain structure.
Gene3D G3DSA:1.10.1200.10; ACP_like; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00501; AMP-binding; 1.
PF07993; NAD_binding_4; 1.
PF00550; PP-binding; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001617; Alpha-AR; 1.
PRINTS PR00154; AMPBINDING.
TIGRFAMs TIGR01733; AA-adenyl-dom; 1.
TIGR03443; alpha_am_amid; 1.
TIGR01746; Thioester-redct; 1.
PROSITE PS50075; ACP_DOMAIN; 1.
PS00455; AMP_BINDING; 1.
PS00012; PHOSPHOPANTETHEINE; FALSE_NEG.
PROSITE graphical view of domain structure (profiles).
Other
ProtoNet O74298.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Lysine biosynthesis; NADP; Oxidoreductase; Phosphopantetheine.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   1409  1409     L-aminoadipate-semialdehyde dehydrogenase large subunit. PRO_0000193151
DOMAIN   863    934  72     Acyl carrier. 
BINDING   896    896        Phosphopantetheine (covalent) (Potential). 
Sequence information
Length: 1409 AA [This is the length of the unprocessed precursor] Molecular weight: 154842 Da [This is the MW of the unprocessed precursor] CRC64: A85DFD397BAB29AE [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAVGTASLQD RLETWAQRLK NLTVSPLTRD YPDTQKTDSK RVIEAFESLQ LPKAKLTGSS 

        70         80         90        100        110        120 
SSFIAFLTAF IILVARLTGD EDIAVGTNSN EDGRAFVIRV PIDTSESFAQ LYAKVDKAYK 

       130        140        150        160        170        180 
EGSSQIVPLG SLRSYIQEKS KSERTPVLFR FAAYDAPASS QDYPANTFDT TDLVVNVAPG 

       190        200        210        220        230        240 
SAEVELGAYY NQRLFSSARI AFILKQLASI ASNAAANPDE AIGRIDLMTE DQRALLPDPT 

       250        260        270        280        290        300 
CNLNWSNFRG AIHDIFTANA ERHPEKLCVV ETQSSSSPHR EFTYRQINEA SNILGHHLVR 

       310        320        330        340        350        360 
SGIQRGEVVM VYAYRGVDLV VAVMGILKAG ATFSVIDPAY PPERQNIYLD VARPRALVNI 

       370        380        390        400        410        420 
AKATKDAGEL SDIVRTFIDE NLELRTEIPA LALLDDGTLA GGSINGQDVF ANDVALKSKP 

       430        440        450        460        470        480 
TGVVVGPDSI PTLSFTSGSE GRPKGVRGRH FSLAYYFPWM SETFKLTPDE KFTMLSGIAH 

       490        500        510        520        530        540 
DPIQRDIFTP LFLGAQLLVP AREDIQNEKL AEWIEKYGAT ITHLTPAMGQ ILVGGASAQF 

       550        560        570        580        590        600 
PALHHAFFVG DILIKRDCRS LQGLAPNVSI VNMYGTTETQ RAVSYYEIPS YASNEGYLNN 

       610        620        630        640        650        660 
MKDVIMAGRG MLDVQMLVVN RYDPTRLCAI GEVGEIYVRA GGLAEGYLGS PELSAKKFLN 

       670        680        690        700        710        720 
NWFVNPEIWA EKDQAESRNE PWRQFYVGPR DRLYRSGDLG RYTPSGDVEC SGRADDQVKI 

       730        740        750        760        770        780 
RGFRIELGEI DTHLSQHPLV RENVTLVRRD KDEEPTLVSY FVPDMNKWAS WLESKGLKDD 

       790        800        810        820        830        840 
DSDSEGMVGL LRRFRPLRDD AREHLRTKLP TYAVPTVIIP LKRMPLNPNG KIDKPALPFP 

       850        860        870        880        890        900 
DTAELSAAAP RRASSALQAL SETEQTLAQV WAKLIPNVTS RMIGPDDSFF DLGGHSILAQ 

       910        920        930        940        950        960 
QMFFELRRKW RVIDISMNAI FRSPTLKGFA SEIDRLLAME SFATSDDKTL AVQAANEPDD 

       970        980        990       1000       1010       1020 
EYSKDAVQLV NELPKTFPQR TEAMLTSEPT VFLTGATGFL GAHILRDLLT RKSPSTKVVA 

      1030       1040       1050       1060       1070       1080 
LVRAKTEELA LERLRSTCRA YGFWDEAWTA KLQAVCGDLG KPQFGLSQSV WDDLTNRVDA 

      1090       1100       1110       1120       1130       1140 
VIHNGALVHW VYPYATLRPA NVMGTIDALK LCASGKAKQF AFVSSTSALD KDRYVQESER 

      1150       1160       1170       1180       1190       1200 
IIAAGGNGIS EDDDMEGSRV GLGTGYGQSK WAGEYLVKEA GRRGLRGTIV RSGYVLGDSV 

      1210       1220       1230       1240       1250       1260 
TGTTNTDDFL IRMLKGCIQI GLRPNIFNTV NMVPVDHVAR IVIATAFHPP ATGVNVAHVT 

      1270       1280       1290       1300       1310       1320 
GHPRLRFNQF LGALELYGYN VPQVDYVPWS TSLEQYVNDG EHNDKESQHA LMPLYHFVTS 

      1330       1340       1350       1360       1370       1380 
DLPSNTKAPE LDDVNAATAL RADATWSGVD ASAGAGVTEE LVGLYASYLV QTGFLPAPTV 

      1390       1400 
AGARPLPAAQ ISEEQKKTLL SVGGRGGTS
O74298 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by kr flag YPRC Korea Mirror sites: Australia Brazil Canada China Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!