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UniProtKB/Swiss-Prot entry O74024

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHE3_THEPR
Primary accession number O74024
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on November 1, 1998 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 47)
Name and origin of the protein
Protein name Glutamate dehydrogenase
Synonyms GDH
EC 1.4.1.3
Gene name
Name: gdhA
Synonyms: gdh
From
Thermococcus profundus [TaxID: 49899] 
Taxonomy Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; Thermococcus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Higuchi S., Kobayashi T., Kimura K., Horikoshi K., Kudo T.;
"Molecular cloning, nucleotide sequence and expression in Escherichia coli of hyperthermophilic glutamate dehydrogenase gene from Thermococcus profundus.";
J. Ferment. Bioeng. 83:405-411(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
D87814; BAA28943.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T44308; T44308.
3D structure databases
PDB
1EUZ; X-ray; 2.25 A; A/B/C/D/E/F=1-419.[ExPASy / RCSB / EBI]
PDBsum 1EUZ; -.
ModBase O74024.
Ontologies
GO
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0004353; Molecular function: glutamate dehydrogenase [NAD(P)+] activity (inferred from electronic annotation from EC).
GO:0006520; Biological process: amino acid metabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR006095; Glu/Leu/Phe/Val_DHase.
IPR006096; Glu/Leu/Phe/Val_DHase_C.
IPR006097; Glu/Leu/Phe/Val_DHase_dimer.
IPR014362; Glu_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR11606:SF2; GLFV_DH; 1.
Pfam PF00208; ELFV_dehydrog; 1.
PF02812; ELFV_dehydrog_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000185; Glu_DH; 1.
PRINTS PR00082; GLFDHDRGNASE.
PROSITE PS00074; GLFV_DEHYDROGENASE; 1.
Other
ProtoNet O74024.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; NAD; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   419  419     Glutamate dehydrogenase. PRO_0000182763
NP_BIND   219   225  7     NAD (Potential). 
ACT_SITE   105   105        By similarity. 
HELIX   5    17  13      
HELIX   25    32  8      
STRAND   35    45  11      
STRAND   51    62  12      
STRAND   66    74  9      
HELIX   80    96  17      
STRAND   102   110  9      
HELIX   117   131  15      
HELIX   132   134  3      
TURN   137   139  3      
STRAND   140   143  4      
HELIX   150   164  15      
HELIX   170   173  4      
HELIX   179   181  3      
HELIX   190   206  17      
STRAND   214   218  5      
HELIX   222   233  12      
STRAND   238   243  6      
STRAND   248   250  3      
HELIX   257   267  11      
STRAND   268   270  3      
STRAND   277   279  3      
HELIX   281   284  4      
STRAND   290   294  5      
STRAND   296   299  4      
TURN   303   305  3      
HELIX   306   308  3      
STRAND   312   315  4      
STRAND   318   320  3      
HELIX   324   332  9      
STRAND   336   338  3      
HELIX   340   343  4      
HELIX   346   359  14      
HELIX   366   391  26      
HELIX   395   413  19      
Sequence information
Length: 419 AA [This is the length of the unprocessed precursor] Molecular weight: 46700 Da [This is the MW of the unprocessed precursor] CRC64: 1DF3C1122E562706 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MVEIDPFEMA VKQLERAAQY MDISEEALEW LKKPMRIVEV SVPIEMDDGS VKVFTGFRVQ 

        70         80         90        100        110        120 
HNWARGPTKG GIRWHPAETL STVKALATWM TWKVAVVDLP YGGGKGGIIV NPKELSEREQ 

       130        140        150        160        170        180 
ERLARAYIRA VYDVIGPWTD IPAPDVYTNP KIMGWMMDEY ETIMRRKGPA FGVITGKPLS 

       190        200        210        220        230        240 
IGGSLGRGTA TAQGAIFTIR EAAKALGIDL KGKKIAVQGY GNAGYYTAKL AKEQLGMTVV 

       250        260        270        280        290        300 
AVSDSRGGIY NPDGLDPDEV LKWKREHGSV KDFPGATNIT NEELLELEVD VLAPAAIEEV 

       310        320        330        340        350        360 
ITEKNADNIK AKIVAEVANG PVTPEADDIL REKGILQIPD FLCNAGGVTV SYFEWVQNIN 

       370        380        390        400        410 
GYYWTEEEVR EKLDKKMTKA FWEVYNTHKD KNIHMRDAAY VVAVSRVYQA MKDRGWVKK
O74024 in FASTA format

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