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UniProtKB/Swiss-Prot entry O69497

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GABD1_MYCLE
Primary accession number O69497
Secondary accession numbers None
Integrated into Swiss-Prot on November 13, 2007
Sequence was last modified on August 1, 1998 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 53)
Name and origin of the protein
Protein name Succinate-semialdehyde dehydrogenase [NADP+]
Synonyms SSADH
SSDH
EC 1.2.1.16
Gene name
Name: gabD1
OrderedLocusNames: ML2573
ORFNames: MLCB1883.11c
From
Mycobacterium leprae [TaxID: 1769] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=TN;
DOI=10.1038/35059006; PubMed=11234002 [NCBI, ExPASy, EBI, Israel, Japan]
Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G.;
"Massive gene decay in the leprosy bacillus.";
Nature 409:1007-1011(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AL022486; CAA18560.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL583926; CAC32105.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T44871; T44871.
RefSeq NP_302648.1; -.
3D structure databases
HSSP P05091; 1O04. [HSSP ENTRY / PDB]
ModBase O69497.
Enzyme and pathway databases
BioCyc MLEP272631:ML2573-MON; -.
Organism-specific databases
Leproma ML2573; -.
Ontologies
GO
GO:0009013; Molecular function: succinate-semialdehyde dehydrogenase [NAD(P)+] activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; FALSE_NEG.
Genome annotation databases
GeneID 910883; -.
GenomeReviews AL450380_GR; ML2573.
KEGG mle:ML2573; -.
NMPDR fig|272631.1.peg.1520; -.
Phylogenomic databases
HOGENOM O69497; -.
Genome annotation databases
CMR O69497; ML2573.
Other
ProtoNet O69497.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NADP; Oxidoreductase; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   457  457     Succinate-semialdehyde dehydrogenase [NADP+]. PRO_0000310703
NP_BIND   209   214  6     NAD or NADP (By similarity). 
ACT_SITE   231   231        By similarity. 
ACT_SITE   265   265        By similarity. 
Sequence information
Length: 457 AA [This is the length of the unprocessed precursor] Molecular weight: 48879 Da [This is the MW of the unprocessed precursor] CRC64: 1EEF6444A6DD13BD [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSIATINPAT GETVKTFTPT TQDEVEDAIA RAYARFDNYR HTTFTQRAKW ANATADLLEA 

        70         80         90        100        110        120 
EANQSAALMT LEMGKTLQSA KDEAMKCAKG FRYYAEKAET LLADEPAEAA AVGASKALAR 

       130        140        150        160        170        180 
YQPLGVVLAV MPWNFPLWQT VRFAAPALMA GNVGLLKHAS NVPQCALYLA DVIARGGFPE 

       190        200        210        220        230        240 
DCFQTLLISA NGVEAILRDP RVAAATLTGS EPAGQAVGAI AGNEIKPTVL ELGGSDPFIV 

       250        260        270        280        290        300 
MPSADLDAAV ATAVTGRVQN NGQSCIAAKR FIAHADIYDE FVEKFVARME TLRVGDPTDP 

       310        320        330        340        350        360 
DTDVGPLATE SGRAQVEQQV DAAAAAGAVI RCGGKRPDRP GWFYPPTVIT DITKDMALYT 

       370        380        390        400        410        420 
DEVFGPVASV YCATNIDDAI EIANATPFGL GSNAWTQNES EQRHFIDNIV AGQVFINGMT 

       430        440        450 
VSYPELPFGG IKRSGYGREL STHGIREFCN IKTVWIA
O69497 in FASTA format

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