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UniProtKB/Swiss-Prot entry O68965

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MI2D_RHIME
Primary accession number O68965
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on November 2, 2001 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 53)
Name and origin of the protein
Protein name Inositol 2-dehydrogenase
Synonyms EC 1.1.1.18
Myo-inositol 2-dehydrogenase
MI-dehydrogenase
Gene name
Name: idhA
Synonyms: iolG
OrderedLocusNames: RB1194
ORFNames: SMb20899
From
Rhizobium meliloti (Sinorhizobium meliloti) [TaxID: 382] [HAMAP proteome]
Encoded on Plasmid pSymB (megaplasmid 2).
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION, AND FUNCTION AS MI-DEHYDROGENASE.
STRAIN=1021;
PubMed=9802033 [NCBI, ExPASy, EBI, Israel, Japan]
Galbraith M.P., Feng S.F., Borneman J., Triplett E.W., de Bruijn F.J., Rossbach S.;
"A functional myo-inositol catabolism pathway is essential for rhizopine utilization by Sinorhizobium meliloti.";
Microbiology 144:2915-2924(1998).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=1021;
DOI=10.1073/pnas.161294698; PubMed=11481431 [NCBI, ExPASy, EBI, Israel, Japan]
Finan T.M., Weidner S., Wong K., Buhrmester J., Chain P., Vorhoelter F.J., Hernandez-Lucas I., Becker A., Cowie A., Gouzy J., Golding B., Puehler A.;
"The complete sequence of the 1,683-kb pSymB megaplasmid from the N2-fixing endosymbiont Sinorhizobium meliloti.";
Proc. Natl. Acad. Sci. U.S.A. 98:9889-9894(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF059313; AAC70005.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL591985; CAC49594.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR B95991; B95991.
RefSeq NP_437734.1; -.
3D structure databases
ModBase O68965.
Enzyme and pathway databases
BioCyc SMEL266834:SMB20899-MON; -.
Ontologies
GO
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0050112; Molecular function: inositol 2-dehydrogenase activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000683; GFO/IDH/MocA_N.
IPR016040; NAD(P)-bd.
IPR004104; OxRdtase_C.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF01408; GFO_IDH_MocA; 1.
PF02894; GFO_IDH_MocA_C; 1.
Pfam graphical view of domain structure.
Genome annotation databases
GeneID 1237525; -.
GenomeReviews AL591985_GR; RB1194.
KEGG sme:SMb20899; -.
NMPDR fig|266834.1.peg.5829; -.
Phylogenomic databases
HOGENOM O68965; -.
Genome annotation databases
CMR O68965; RB1194.
Other
ProtoNet O68965.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase; Plasmid.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   330  330     Inositol 2-dehydrogenase. PRO_0000091775
CONFLICT   226   226        S -> A (in Ref. 1; AAC70005). 
Sequence information
Length: 330 AA [This is the length of the unprocessed precursor] Molecular weight: 35147 Da [This is the MW of the unprocessed precursor] CRC64: 06F5FBBAC7484A58 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTVRFGLLGA GRIGKVHAKA VSGNADARLV AVADAFPAAA EAIAGAYGCE VRTIDAIEAA 

        70         80         90        100        110        120 
ADIDAVVICT PTDTHADLIE RFARAGKAIF CEKPIDLDAE RVRACLKVVS DTKAKLMVGF 

       130        140        150        160        170        180 
NRRFDPHFMA VRKAIDDGRI GEVEMVTITS RDPSAPPVDY IKRSGGIFRD MTIHDFDMAR 

       190        200        210        220        230        240 
FLLGEEPVSV TATAAVLIDK AIGDAGDYDS VSVILQTASG KQAIISNSRR ATYGYDQRIE 

       250        260        270        280        290        300 
VHGSKGAVAA ENQRPVSIEI ATGDGYTRPP LHDFFMTRYT EAYANEIESF IAAIEKGAEI 

       310        320        330 
APSGNDGLAA LALADAAVRS VAEKRQISIA
O68965 in FASTA format

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